Lab retreat last week - we had some really delicious food prepared by various different lab members. My contribution was Pasta alla Norma (yes, that’s Ricotta Salata). Many thanks to University of Bristol people (Jon, Berni, Harriet) for hosting!
Rupert Beale
@bealelab.bsky.social
Group Leader, Cell Biology of Infection Lab @thecrick; Nephrologist @Royal Free Hospital. Own views etc.
Took us 40 years but here it is: Monteverdi 1610 recording with @ecse1610.bsky.social Buy it (buy it?) here or stream for free of course... orcd.co/ifagmont1610 (Actual release Sep 4th but a few films are appearing now.
On the plus side this doesn’t look like a cabinet prepared to spend political capital on the so called assisted dying bill. Let’s hope.
In the past 10 years there have been 10 education Secretaries of State and 9 for health. This is no way to run anything, leadership of my second XI village cricket team has been more stable (and probably on average more able individuals).
Went to an incredible concert tonight at Sir Ian McKellan’s house. Simon O’Neill singing Dichterliebe accompanied by my father. Surreal, in the best way.
Paccheri stuffed with aubergine, spinach and ricotta in tomato sauce with scamorza affumicato.
Really extraordinary Easter Vigil Mass I sang at: 37 confirmations!!!! Mostly also getting baptised rather than switching denominations. Nothing like it in my lifetime. We sang Byrd Haec Dies.
Wonderful news from Scotland. So many congratulations to my colleagues campaigning against assisted dying who never gave up.
Am at the Old Vic. Lady behind me is recounting how she went to the opening night of Arcadia with Isaiah Berlin. Who apparently remarked “oh it’s just too clever clever clever”.
Good thread. The bill is really, really bad.
James Ball@jamesrball.com · 6mo agoThe accusation that the Lords are “obstructing democracy” by supporters of the assisted dying bill is a ridiculous one that shows up the flaws in this process that have been there from the very beginning – which have repeatedly been covered up by heated rhetoric (1/?)
Fresh from organising #ksautophagy25 with Christie and Leon I’m now off to #ksautophagy26 - doesn’t seem that long ago! Hopefully people will be interested to hear about viruses and CASM.
Did they read what they cite? In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease! www.nature.com/articles/s41... www.annenbergpublicpolicycenter.org/public-confi...
João Monteiro and the editorial board of @naturemedicine.bsky.social should be ashamed of themselves for publishing this trash. www.nature.com/articles/s41...
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID) - Nature Medicine
Preparing for tomorrow’s threats by enhancing our ability to help patients today.
nature.com
My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
biorxiv.org
Oh! And happy St Lucy’s Day, one and all, may your eyes be healthy and free of infection
Just a few weeks left to apply for our clinical PhD programme. We're looking for clinicians who are passionate about research to join the 3-year fully funded programme. Learn more and see what positions are available ⬇️ www.crick.ac.uk/careers-and-...
Doctoral clinical fellows
The Crick's clinical PhD programme.
crick.ac.uk
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...
Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses
crick.ac.uk
@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?
The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS. All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience. This will, and already does, cost lives.
Brandy Zadrozny@brandyzadrozny.bsky.social · 12mo agoNew: I spent the week looking into the cancelled mRNA contracts. Interviews with HHS officials and MAGA and MAHA influencers reveal an HHS agency plagued by dysfunction as Kennedy chips away at the nation’s public health. www.msnbc.com/news/news-an...
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.
cell.com
I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.
@ginganinja2507.bsky.social · 12mo agoI learned beginner Basque at UChicago, an experience that i still cherish. This is fucking appalling to hear