#AQLM Series🧵: Microscopy Mistakes -- oh, FRAP! What happens after a #fluorescent molecule is bleached with a laser? In FRAP #microscopy, the recovery itself is the measurement. 🔬 📸 @3i Intelligent Imaging Innovations on the Marianas platform; 63× objective and a Photometrics Prime 95B camera. (1/7)

Our #CellLineOfTheWeek is Histone H2B! 🧬 Our human iPS cell lines & plasmids – fluorescently-tagged to illuminate structures – are available for just the cost of shipping to accelerate scientific discovery. 📦 Distributed by @coriellinstitute.bsky.social & @addgene.bsky.social

I am really excited to announce that the new Stevenson Lab is up and running at the University of Bristol. See what we are up to on our new website stevenson-laboratory.com

Home - The Stevenson Laboratory

Research Our laboratory conducts groundbreaking research aimed at understanding the molecular mechanisms that govern secretory pathway structure and function. Check out out ongoing projects! Meet the ...

stevenson-laboratory.com

We all need a little nudge sometimes when it comes to writing. The Node is hosting a great writing challenge to help beat that dreaded writing procrastination. I cannot wait to read the community's entries and there is a chance to win £200!

Focused Writing Session Animation

ALT: Focused Writing Session Animation

static.klipy.com

the Node@the-node.bsky.social · 5d ago

Win £200 for your post on the Node This is your opportunity to publish your piece at last for a chance to win £200. We are hosting an exciting writing challenge to help motivate you to share your piece with the Node’s community of biologists by 4 September. thenode.biologists.com/win-200-for-...

Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...

Postdoctoral Research Assistant - UOD2336

Closing date: Thursday 27 August 2026, 23:59

dundee.ac.uk

arXiv has spun out as an independent non-profit like openRxiv. Today they announce their new CEO and founding Board blog.arxiv.org/2026/07/30/a...

arXiv welcomes inaugural CEO and founding Board of Directors

arXiv welcomes inaugural CEO and founding Board of Directors

blog.arxiv.org

How do poxviruses initiate infection after getting into the cytoplasm? With Tom Calcraft, @miguel-virus-cells.bsky.social & Peter Rosenthal, @crick.ac.uk we solved the structure of the vaccinia virus portal that mediates viral assembly and early mRNA and subsequent genome release. rdcu.be/fwGTn

In situ structure of the poxvirus portal complex

Nature - Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral...

rdcu.be

Huge congrats to the many authors who over MANY years worked on this (but especially @karaehunt.bsky.social , @trevorbrandt.bsky.social, Karina, @shaharsu.bsky.social and @remenecker.bsky.social. www.nature.com/articles/s41...

Rational design of disordered proteins for sequence–function investigation - Nature

GOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.

nature.com

Alex Holehouse@alexholehouse.bsky.social · 5mo ago

New (well, very old, but 100% updated) preprint: Rational design of disordered proteins for systematic sequence-to-function investigation Work done in collaboration with @shaharsu.bsky.social lab - check out the three (3) threads from the folks who did the work!

Every trainee thinks that they can write a paper whenever they want. Some divine intervention will happen as and when necessary, but there is no need to practice anything. Newsflash: You can't just wake up one day and start writing. Just like you can't wake up one day and start playing the cello.

If I were an Early Career Researcher (#ECR) today, I wouldn’t join a lab that doesn’t #preprint (the PI agreed to keep paying me until my paper is finally published). It now takes ages to get papers through peer review, and without preprints you’re putting your future in someone else’s hands.

We've seen a significant amount of discussion online following STFC's update on its prioritisation decisions. We want to make sure the facts are clear.

Igor Yakunin, Sean Munro @cellbiol-mrclmb.bsky.social and colleagues find that the Golgi vesicle tether p115 can bind directly to the ER exit site organiser Sec16A. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...

We're pleased to be supporting the FASEB Lipid Droplets/Phospholipids conference taking place this week. If you're attending the meeting and would like to discuss a submission, please get in touch. @faseborg.bsky.social #LipidSRC #PLSRC

Everyone says AI will accelerate science. I don't think it will -- at least not in biology, and at least not soon. New post where I explain why, and how the productivity paradox can be resolved: blekhman.substack.com/p/why-ai-wil...

Why AI will not speed up science (yet)

You can see AI everywhere except in the productivity statistics

blekhman.substack.com

Imagine that in pre-publication peer review, the reliability of a 3-reviewer composite is .70. The journal accepts the top 10% of papers according to average review score. What is the reliability of the original reviewers in the subset of published papers? (Answer in alt text)

Lattice light sheet data taken by the participants of #IALSJanelia 2026, with guidance from @cmhobson.bsky.social. I rendered the actin dynamics using #AGAVE 🔬

Microscopy Nodes 3.1 is out for Blender 5.2! 🎉 This has cool new features for conditional masking, working with even larger data (regional upscaling), and data manipulation! Watch the new youtube tutorials that explain the features: www.youtube.com/playlist?lis...

New -cytosis term has dropped on bioRxiv "We term this process ‘skoupocytosis’ after the Greek word for garbage” www.biorxiv.org/content/10.6...

Microglia extract neuronal proteolytic organelles via skoupocytosis

Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their s...

biorxiv.org

The Curvenote Reader button is live on bioRxiv! 😎 Click it to explore papers in a new way—zoom figures, pull up references without leaving the page. Button appears 48 hours after papers drop. Feedback? DM us or hit the GitHub repo. openrxivlabs.org/articles/rea...

Why we’re expanding the openRxiv Labs Curvenote Reader experiment

Read on for early results and what we’ll be looking at in the next phase.

openrxivlabs.org

🚨🚨Final reminder for abstract submission deadline next Tuesday (28th)! Please RT 🙏

Jonny Nixon-Abell@abelljonny.bsky.social · 7mo ago

‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏

Remember the Frontiers AI rat penis incident? I wondered how that affected submissions and (sorry to sound clickbait-y) the answer surprised me... quantixed.org/2026/07/23/n...

@wsctt.bsky.social and Nimo Abdullah from @sporemohan.bsky.social lab demonstrate the potential of 3-iodotyrosine containing FPs for expansion microscopy 🔬🐟🌈 Happy to have played a small role in this exciting project Findings available @micropub7n.bsky.social micropublication.org/journals/bio...

Blast from the past! Did you know you can create clean, readable notebooks for the ImageJ Macro language? A great way to build tutorials, teaching materials, and [mentally] reproducible image analysis workflows. 👨‍🏫📜🚀 github.com/haesleinhuep...

Wow, these vinyl colours are getting a bit out of hand...

Jobs: My fantastic membrane biologist colleague Satyajit Mayor (warwick.ac.uk/fac/sci/med/...) has a really exciting single molecule #biophysics PDRA position currently advertised based at @warwickmed.bsky.social warwick-careers.tal.net/vx/lang-en-G...

I know December seems a long way off but this should be a great meeting! AND I believe it's being held the day before the famed membrane trafficking meeting (also in London).

British Society for Cell Biology@bscb-official.bsky.social · 2w ago

We are sponsoring the 2026 UK Cell Motility Club symposium: 🗓️ 17 December 2026, 10:00-19:00 📍King’s College London To find out more and register, visit: cytoskeleton.wixsite.com/londoncellmo... Thanks to @matthias-krause.bsky.social & @squeezycellslab.bsky.social for organising

Check out this either somewhat significant or highly significant factoid.

American Statistical Association History of Statistics @hos-asa.bsky.social · 2w ago

Few statisticians know that Frank Yates, pioneer of experimental design, is responsible for the annoying practice of indicating 3 tiers of statistical significance by stars (*p ≤ 0.05, **p ≤0.01, ***p ≤ 0.001). He soon regretted it and “vehemently opposed its unthinking use”. And here we are.

A post about how to make microscopy images as accessible as possible. quantixed.org/2026/07/21/c...