A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle–based mRNA vaccines www.science.org/doi/10.1126/...
@bhardwajlab.bsky.social
Laboratory of Dr. Nina Bhardwaj🔬 @TischCancer @SinaiImmunol Immunology & Immunotherapy Posts by Lab Members
So proud to see our PI recognized with the 2026 CLIP & Technology Impact Award from @cancerresearchinst.bsky.social!🎉https://www.cancerresearch.org/blog/2026-clip-tech?utm_source=Social&utm_medium=LinkedIn&utm_campaign=CRI&utm_id=CRI
From Bold Ideas to Breakthroughs: Introducing CRI’s 2026 CLIP & Technology Impact Award Projects - Cancer Research Institute
Discover CRI’s 2026 CLIP and Technology Impact Award projects — funding bold cancer immunotherapy research and new tools to advance treatments.
cancerresearch.org
A publication in the Clinical and Human Immunology special collection finds that notch signaling may contribute to long-term antigen-specific CD8+ T cell responses after mRNA vaccination. Learn more and read the whole collection in The JI: https://ow.ly/gWTS50ZnNRw.
Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer
Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer
Kureshi et al. show that combining an innate immune agonist and immune checkpoint blockade effectively treats pancreatic tumors in mouse models. Tumor control depends on cDC2-primed CD4+ T cells and IFNγ. Human PDAC retains cDC2s and CD4+ T cells after chemotherapy, suggesting a potential therapeutic approach for PDAC.
dlvr.it
Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells
Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells
Nature Biomedical Engineering, Published online: 07 July 2026; doi:10.1038/s41551-026-01738-zChemRNAs are chemically synthesized RNA lacking typical mRNA features that are nevertheless efficiently translated by CD8+ T cells to overcome limitations associated with in vitro transcription for developing anti-cancer mRNA vaccines.
go.nature.com
Check out our latest review👏! We dive deep into how cDC1s orchestrate anti-tumor immunity through cross-presentation, immune networking, and spatial organization.
Journal of Experimental Medicine@jem.org · 4mo agoWard, Kar, Balan, and Bhardwaj @bhardwajlab.bsky.social review how conventional type 1 #DendriticCells (cDC1s) coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. rupress.org/jem/article/... #CancerFocus #Immunotherapy
Oncologists and researchers at the ASCO 2026 conference give a standing ovation after the experimental drug daraxonrasib nearly doubles survival in a metastatic pancreatic cancer trial! #AGoodPlace Source: www.reddit.com/r/Damnthatsi...
Huge congratulations to @michelletran9.bsky.social on graduating!🎓 The Bhardwaj lab team loved celebrating your incredible hard work and achievements over dinner. We are so proud of you and can't wait to see what you do next!✨ Cheers to the next chapter!🥂 #LabFamily #Graduation
Mestrallet et al. focused on resistance mechanisms that limit anti-PD-1 efficacy in colorectal cancer (50% to 100% failure depending on mismatch repair status). bit.ly/49qWVm8 @sinaiimmuno.bsky.social @gmestrallet.bsky.social @bhardwajlab.bsky.social
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models - @mitkochinstitute.bsky.social go.nature.com/42td2fh
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models - Nature Biotechnology
Immune-remodeling mRNAs delivered in lipid nanoparticles boost antitumor immunity.
go.nature.com
Trading pipettes for axes! Lab bonding last week was a 10/10 vibe. Looking at the lineup, who do you think lowkey had the best aim?🎯
Huge congratulations to Michelle on officially finishing her MD-PhD. It’s been an incredible journey watching her balance the bench and the clinic with such dedication. We couldn’t be prouder of everything she’s accomplished. Cheers to Dr. Michelle!🥂 ##MDPhD #Graduation
New paper from the lab! www.cell.com/cell-reports... @gmestrallet.bsky.social @sinaiimmuno.bsky.social
Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer
Mestrallet et al. show that T cell-myeloid interactions determine response to PD-1 blockade in colorectal cancer. Targeting TREM2 macrophages together with LAG3, CTLA4, and PD-1 reprograms the tumor m...
cell.com
Guillaume Mestrallet@gmestrallet.bsky.social · 5mo agoGlad to share our work about resistance to immunotherapy! We discovered a combination therapy allowing to eliminate CRC tumors. We also identified the T cell and macrophage subsets mediating the response. Thanks to the team! www.cell.com/cell-reports... Plus, a small cartoon summarizing the study.
Glad to share our work about resistance to immunotherapy! We discovered a combination therapy allowing to eliminate CRC tumors. We also identified the T cell and macrophage subsets mediating the response. Thanks to the team! www.cell.com/cell-reports... Plus, a small cartoon summarizing the study.
Nice work from our Sinai colleagues : Gemcitabine plus nivolumab with carboplatin or oxaliplatin in cisplatin-ineligible patients with metastatic urothelial carcinoma: a randomized phase II trial aacrjournals.org/clincancerre...
Gemcitabine plus nivolumab with carboplatin or oxaliplatin in cisplatin-ineligible patients with metastatic urothelial carcinoma: a randomized phase II trial
Abstract. Purpose Oxaliplatin has demonstrated the ability to sensitize tumors to immune checkpoint blockade through its immunomodulatory properties in model systems of cancer. This randomized trial a...
aacrjournals.org
Eight of 16 patients in a clinical trial of an investigational mRNA vaccine for pancreatic cancer at @mskcancercenter.bsky.social had dramatic immune responses. The study, which was featured on @cnn.com, was presented at the AACR Annual Meeting 2026. www.cnn.com/2026/04/20/h... #AACR26
After a year of turmoil, cancer researchers see promising signs for mRNA vaccines | CNN
The mRNA-based Covid vaccines helped blunt the impact of the pandemic but also sparked political backlash that has threatened to slow or derail dozens of potential cancer treatments. Now there are sig...
cnn.com
Type 1 IFN primes cross-dressing of cDCs with peptide–MHC-I complexes from non-haematopoietic cells, explaining ability of mRNA vaccines to activate CD8+ T cells against antigens not encoded by the vaccine @nature.com @washumedicine.bsky.social #Murphy www.nature.com/articles/s41...
mRNA vaccines engage unconventional pathways in CD8+ T cell priming - Nature
mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and ...
nature.com
Single-cell spatial transcriptomic analysis of human skin anatomy www.nature.com/articles/s41...
Single-cell spatial transcriptomic analysis of human skin anatomy - Nature Genetics
This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and disease...
nature.com
New article! 👏One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development | Science Advances www.science.org/doi/10.1126/...
One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development
PEG-free, one-component Janus dendrimers deliver mRNA with high stability and strong immunity, enabling scalable vaccines.
science.org
In 2025, the AACR Grants Program distributed nearly $10 million to support 50 meritorious research projects. Learn more in the AACR Annual Impact Report: buff.ly/I45TBUi
mRNA Vaccines for Cancer Treatment. www.sciencedirect.com/science/arti...
mRNA Vaccines for Cancer Treatment
sciencedirect.com
Expanding global access to mRNA vaccines www.nature.com/articles/s44...
Expanding global access to mRNA vaccines - Nature Reviews Bioengineering
mRNA vaccines combine rapid design, scalable manufacturing and strong safety profiles with applications across infectious diseases, cancer and autoimmune disorders. However, global access to mRNA vacc...
nature.com
Congratulations @michelletran9.bsky.social 🎉for matching at UCSD Internal Medicine Residency Research Track with a guaranteed Hem/Onc fellowship! So proud of all your accomplishments & excited to see the impact you’ll make as a physician-scientist.
mRNA-based CAR T cell engineering: Unmodified mRNA enables high CAR expression without innate immune activation in T cells www.cell.com/molecular-th...
mRNA-based CAR T cell engineering: Unmodified mRNA enables high CAR expression without innate immune activation in T cells
Proinflammatory innate immune activation by unmodified mRNA is a limitation, which mandates mRNA-nucleoside modification across applications. However, Drzeniek and colleagues reveal that it is absent ...
cell.com
Delighted to share our new paper, led by our recent PhD graduate and star scientist 🌟 @michelletran9.bsky.social.
Michelle Tran, PhD@michelletran9.bsky.social · 7mo agoExcited to share the final first-author paper of my PhD is online in Cancer Discovery @aacrjournals.bsky.social! doi.org/10.1158/2159... We identify an SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in bladder cancer @bhardwajlab.bsky.social
Excited to share the final first-author paper of my PhD is online in Cancer Discovery @aacrjournals.bsky.social! doi.org/10.1158/2159... We identify an SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in bladder cancer @bhardwajlab.bsky.social
A paper published in Nature presents Evo 2: an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and provides a rich generative model for researchers in biology. 🧪
Genome modelling and design across all domains of life with Evo 2 - Nature
Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and provides a rich generative model for researchers in biology.
go.nature.com
www.nature.com/articles/s41...
The promises and challenges of neoantigen cancer vaccines - Nature Biotechnology
Surveying recent progress in neoantigen cancer vaccine development, this Review highlights areas where further technological advances and optimized trial design could enhance clinical impact.
nature.com
Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial www.nature.com/articles/s41...
Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial - Nature Medicine
In a prespecified ancillary analysis of the COSMOS randomized trial, supplementation with daily multivitamins, but not with cocoa extract, over the course of 2 years decreased biological aging, as mea...
nature.com