New paper out in @thelancet.com! In >4,000 people with Down syndrome, we show when epilepsy emerges and its clinical impact. Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study - The Lancet www.thelancet.com/journals/lan...

Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study

Epilepsy increases sharply after symptomatic Alzheimer's disease onset in people with Down syndrome. The association of epilepsy with reduced survival and accelerated cognitive decline underscores the...

thelancet.com

New paper out from postdoctoral fellow in my lab, Dr. Jiaojiao Guo examining the expanding role of electroencephalography (EEG) in neurodegenerative disease and its utility in dementia. Check it out! www.nature.com/articles/s44...

For decades, Alzheimer’s therapies assumed more acetylcholine = better memory. Our new paper in @alzdemjournals.bsky.social challenges this dogma, showing that the cholinergic system has opposite effects on memory depending on disease stage. 📌 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The cholinergic system exerts opposing effects on memory at different stages of disease progression in Alzheimer's and Down syndrome model systems

INTRODUCTION The long-standing cholinergic hypothesis posits that cholinergic signaling is uniformly deficient in Alzheimer's disease (AD) and Down syndrome (DS). We tested the hypothesis that this ...

alz-journals.onlinelibrary.wiley.com

More than 20 years after their discovery, HFOs are reshaping how we understand epilepsy and increasingly, revealing important links to other brain disorders. In our new paper we reflect on how far the field has come and where it’s headed next. #HFOnews onlinelibrary.wiley.com/doi/10.1002/...

Thank you @cureepilepsy.bsky.social for this honor and for supporting my lab’s work on high frequency oscillations in epilepsy through a CURE Epilepsy award! #HFOnews Congratulations to all awardees!

CURE Epilepsy@cureepilepsy.bsky.social · 8mo ago

Join us in congratulating our latest grantees! Dr. Christos Lisgaras, Nathan Kline Institute Drs. Sonja Bröer, Florian Heyd, Rossella Di Sapia, Free University of Berlin Dr. Mahboubeh Ahmadi, University of California, Riverside Dr. Aswathy AmmothumKandy, @usc.edu Dr. Alex Felix, @upenn.edu

Not just one biomarker, but many! Join our Epilepsy and Aging SIG for an exciting multimodal biomarker session. The session has it all from basic science to neuropsychology, EEG, and more! 🗓️ Monday, December 7, 2:00-3:30pm, Room GWCC B312, Level 3. @amepilepsysoc.bsky.social @yes-ilae.bsky.social

The @amepilepsysoc.bsky.social AES Annual Meeting is quickly approaching - have you marked your calendar for the exciting EEG BIOMARKER CHALLENGE? We will tackle whether EEG biomarkers are disease specific and WHY that matters! 🗓️ Sunday, December 7, 4:00-5:30pm Join us! #HFOnews

Not to be missed!! Mark your calendar! Great networking opportunity.

Young Epilepsy Section@yes-ilae.bsky.social · 10mo ago

AES Annual Meeting 2025 — YES ILAE Reception. Learn about YES, network with peers and discover opportunities. We hope to see you there! @amepilepsysoc.bsky.social @chrislisgaras.bsky.social @alinaivaniuk.bsky.social

This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations’, by Shandilya et al. @chrislisgaras.bsky.social Read at 👉 buff.ly/r3IcOEE

New paper out! We show that EEG biomarkers interact in opposite ways in Alzheimer’s disease (AD) vs. epilepsy. This could explain why epileptiform activity is inconsistently seen in AD—and highlights the need for wideband EEG to uncover these dynamics. #HFOnews www.sciencedirect.com/science/arti...

Opposing interictal dynamics in Alzheimer’s disease and epilepsy

Advanced EEG technology has revealed that epileptiform activity occurs more frequently in Alzheimer’s disease (AD) than previously recognized, prompti…

sciencedirect.com

Greatly enjoyed writing this piece for @braincomms.bsky.social! 🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a... This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.

High frequency opportunities for Alzheimer’s disease

This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

academic.oup.com

Off to beautiful Lisbon to speak the XVIII Workshop on Neurobiology of Epilepsies. Excited about this year’s topic on the resilient brain! Who’s coming?! #HFOnews 🧠 #ILAE @ilae-epilepsy.bsky.social

Exited to share our new work! We found scalp high frequency oscillations (HFOs) in adults with Down syndrome, before the clinical onset of Alzheimer’s dementia and late onset myoclonic epilepsy. HFOs may hold the key to earlier diagnosis #HFOnews alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia

INTRODUCTION Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, ...

alz-journals.onlinelibrary.wiley.com

Interested in how sleep is affected across the Alzheimer’s disease continuum in people with Down syndrome? 💤 Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Impact of Alzheimer's disease on sleep in adults with Down syndrome

INTRODUCTION Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep ...

alz-journals.onlinelibrary.wiley.com

Interested in how preclinical studies can help understand EEG patterns? Take a look at our book chapter! With Marco de Curtis and Premysl Jiruska. link.springer.com/chapter/10.1... #HFOnews

#HFOnews! And first outcome publication of the Third International Workshop on High Frequency Oscillations in Epilepsy. 👇👇

Liset M. de la Prida@lmprida.bsky.social · last yr.

Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...

Off to beautiful Verona for the Spring Hippocampal Research Conference! Who’s coming?! #HFOnews hippo.euroconferences.org/scientific-p...

Scientific Program

If  you determine at the last minute that you cannot travel to Verona, you will have the option of providing a video of your presentation, which will be played in the session in which you are...

hippo.euroconferences.org

Excited to be speaking about High Frequency Oscillations in Epilepsy and Sleep at the 2nd Annual Sleep Conference in NYC!

Happy World Down Syndrome day! We are advocating and are all inspired by individuals with Down syndrome. #WDSD2025

Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews Register here: docs.google.com/forms/d/1e-x...

A great one by @laurentsheybani.bsky.social - on the reading list!

Laurent Sheybani@laurentsheybani.bsky.social · 2y ago

Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how? We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology: doi.org/10.1038/s415... @natrevneurol.bsky.social

www.nia.nih.gov/research/blo...

Beyond amyloid: Targeting a broader range of Alzheimer's disease factors

Learn how Alzheimer's and dementia research targets have evolved.

nia.nih.gov

#HFOnews

Epilepsia Journal@epilepsiajournal.bsky.social · 2y ago

Key point: High-density (HD) grid recordings can be used and interpreted for surgical guidance. doi.org/10.1111/epi.... #epilepsy #ILAE #focalseizures #highfrequencyoscillations #intraoperativetailoring #subduralEEG

Our #EEG Review was selected as @epilepsiajournal.bsky.social Editor’s Featured Article - give it a read here👇 onlinelibrary.wiley.com/doi/10.1111/...

Epilepsia Journal@epilepsiajournal.bsky.social · 2y ago

New Articles in Epilepsia - February 15, 2025 mailchi.mp/ilae/new-art... #epilepsy #ILAE

Super excited to see our 2022 animal model study (onlinelibrary.wiley.com/doi/10.1111/...) showing HFOs in Alzheimer’s model systems replicated in humans! @braincomms.bsky.social The dream of every basic scientist 🤩 Our human study coming very soon :) #HFOnews academic.oup.com/braincomms/a...

High‐frequency oscillations (250–500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy

Objective To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to epilepsy. Methods Exper.....

onlinelibrary.wiley.com

Our review discussing the role of EEG in Epilepsy research is now out @epilepsiajournal.bsky.social @ilae-epilepsy.bsky.social Thanks to all of my co-authors! onlinelibrary.wiley.com/doi/10.1111/...

The role of electroencephalography in epilepsy research—From seizures to interictal activity and comorbidities

Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both for basic and translational studies. Its contributions have advanced our understanding of epilepsy, ...

onlinelibrary.wiley.com

Epilepsia Journal@epilepsiajournal.bsky.social · 2y ago

Key point: Artificial intelligence in EEG analyses, if used in a manner that is validated by expert EEG readers, can potentially increase its information yield. doi.org/10.1111/epi.... #epilepsy #ILAE #analysis #animalmodels #EEG #geneticepilepsies #HFO #mechanisms #preclinical

The time has come!

Matteo Carandini@carandinilab.net · 2y ago

Neuropixels and Optogenetics are delighted to announce the birth of Neuropixels Opto Combining high-resolution electrophysiology and optogenetics Today in bioRxiv 960 sites, 28 emitters, 2 colors By Lakunina, @karolinazsocha.bsky.social, Ladd, et al www.biorxiv.org/content/10.1... (1/2)

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...

🚨NIH-funded postdoc position! Looking for an electrophysiologist (ex/in-vivo) to work with us at Gladstone Institutes on mechanisms of oxidative stress, glucose metabolism, and network hyperexcitability in Alzheimer's disease 🧠 #neurojobs #postdocjob gladstone.wd5.myworkdayjobs.com/en-US/career...

SEEING THROUGH YOUR EYES 👁️: Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus nature.com/articles/s41... 🧵 1/12👇

Sleep microstructure organizes memory replay - Nature

The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

nature.com