Hi Folks, with @lisataxier.bsky.social moving on to open her own lab at Stony Brook, I am in the market for a new postdoctoral fellow who wants to do slice electrophysiology. We have a number of really exciting projects, translational to basic science, that are ephys focused.

Our lab is re-opening the search for a postdoc! The candidate we chose this round unfortunately had to withdraw (2-body problem). If you or someone you know is looking for a postdoc in ephys + spatial navigation + neurodegeneration, come check us out: aeryjoneslab.github.io

Emily A. Aery Jones@emilyaeryjones.bsky.social · 4mo ago

The Aery Jones lab is recruiting another postdoc! If you're interested in neural mechanisms of spatial memory, high-density recordings, cool tasks (like cricket hunting), and/or aging and Alzheimer's, come check us out: aeryjoneslab.github.io. Please pass along to your friends :D

Being in London for the England World Cup game is an AAIC bonus and definitely promises to be an experience… all the pubs are absolutely jammed and standing room only three hours before kickoff

In London for #AAIC26. Looking forward to seeing old friends, meeting new people, and talking science. Say hi if you’re here!

Some rare good news: the House Labor, Health and Human Services, Education, and Related Agencies (LHHS) Subcommittee met this morning and approved a bill that strongly supports NIH. The subcommittee rejected the proposed cuts and recommended funding levels 1.35% above its FY26 recommendation.

New review from Huang lab laying out a temporal, cell-type-specific model of how #APOE4 drives #Alzheimer's. ↑ neuronal APOE4 (preclinical) → SST interneuron loss + hyperexcitability + hypometabolism → glial overactivation (prodromal) → neurodegeneration + dementia. Affects ~2/3 of all AD patients.

Neuron@cp-neuron.bsky.social · 3mo ago

You know GABA as an inhibitor, but that’s not all! We found that tonic GABAergic signaling, mediated by SST-interneurons and alpha5-type receptors, paradoxically facilitates dendritic calcium signals! www.sciencedirect.com/science/arti...

SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors

Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductan…

sciencedirect.com

Longevity-linked #APOE2 helps neurons repair DNA and resist #aging - the protein can also protect #APOE4 neurons. The effect might be transferable, not just genetic. It’s a new therapeutic direction for #Alzheimers www.buckinstitute.org/news/longevi...

Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging

Research from the Buck Institute reveals that the protective APOE2 variant, already associated with exceptional longevity and reduced Alzheimer's risk, keeps human brain cells genomically stable and r...

buckinstitute.org

California Bill Would Create A $23 Billion Fund For University Research

California Bill Would Create A $23 Billion Fund For University Research

A California bill would give voters the chance to vote on whether the state should create a $23 billion bond that would be used to award grants to university researchers.

forbes.com

The Aery Jones lab is recruiting another postdoc! If you're interested in neural mechanisms of spatial memory, high-density recordings, cool tasks (like cricket hunting), and/or aging and Alzheimer's, come check us out: aeryjoneslab.github.io. Please pass along to your friends :D

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

A study in Nature Aging shows that the strongest Alzheimer’s Disease risk gene, APOE4, can make certain brain cells in young mice hyperactive, which can predict later memory decline. The study also implicates Nell2 protein as a contributor to APOE4-driven dysfunction. #Alzsky 🧬🧪

Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis - Nature Aging

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability of hippocampal neurons and can be reversed by targeting Nell2.

go.nature.com

STAT: Trump administration drops court fight to cap NIH payments for research overhead costs by Megan Molteni @statnews.com @mmolteni.bsky.social bit.ly/4tVncB5

Single-Nuclei Transcriptomic Characterization of APOE4-Associated Alzheimer's Disease https://www.biorxiv.org/content/10.64898/2026.04.03.715591v1

Our paper is now online at @nataging.nature.com! Alzheimer’s disease begins decades before symptoms—but what drives those earliest changes is still not well understood. We set out to understand how APOE4 disrupts neuronal and network function across aging. 🧵: 1/15 www.nature.com/articles/s43...

Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis - Nature Aging

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability...

nature.com

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

“Interrogation of data from cerebral organoids demonstrated that, although broad elements of in vivo development are recapitulated in vitro, many layer-specific transcriptomic programs in neuronal maturation are absent.” Got questions about the brain dynamics, organoids are a dead end. Full stop.

Cedric Boeckx@cedricboeckx.bsky.social · 5mo ago

Awesome gift to the research community: a compendium of transcriptomic data for the exploration of neocortical development—gene-level transcriptomic data from ~200(!!!) studies of neocortical development & in vitro models Thanks @carlocolantuoni.bsky.social & colleagues 🙏 @natneuro.nature.com 🧪🧠

Mitochondrial lactate venting limits oxidative stress www.cell.com/cell-metabol...

Mitochondrial lactate venting limits oxidative stress

The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

cell.com

Behind the scenes: postdoc, first author, and star patch-clamper Dennis Tabuena, captured in his native habitat during a press photoshoot.

A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...

Place cells in CA1 lack topographical organization of firing locations | PNAS

Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

pnas.org

Love the smell of a paper acceptance email in the morning

a man with glasses and a mustache is wearing a white shirt and says yes .

ALT: a man with glasses and a mustache is wearing a white shirt and says yes .

media.tenor.com

Congrats @handekarahan.bsky.social & our team members! A potential new drug target for Alzheimer's disease. Targeting the APOE pathway more effectively. Might also enhance neuroprotective pathways, offering resilience against disease progression. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Deletion of neuronal Idol ameliorates Alzheimer's disease–related pathologies via APOE receptors

INTRODUCTION Overexpression of the low-density lipoprotein receptor (LDLR) is known to decrease apolipoprotein E (APOE) levels and alleviate amyloid beta (Aβ) pathology. We hypothesized that inhibit...

alz-journals.onlinelibrary.wiley.com

Please share: I am recruiting a PhD student to join my lab in Oslo! For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys. www.jobbnorge.no/en/available... #NeuroJobs #NeuroSkyence

🔵mTurquoise2-based glucose biosensors TINGL and THINGL from @joachimgoedhart.bsky.social and the Teusink Lab! Find the plasmids here: www.addgene.org/browse/artic...

Joachim Goedhart@joachimgoedhart.bsky.social · 7mo ago

Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...

How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠 Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉

Changyang Linghu@changyanglinghu.bsky.social · 7mo ago

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

The Pearson lab is looking for an enthusiastic research technician to join our team! Come join us in New York City! 🍎🧪 jobs.weill.cornell.edu/NY/job/New-Y... #science #neurobiology #devbio

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3

Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5): grants.nih.gov/faqs#/common...

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

cell.com

asamelson@asamelson.bsky.social · 7mo ago

After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇

New work from our lab! Link: rdcu.be/e0sfU 𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 A quick thread on our findings!

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

npj Dementia - Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

rdcu.be