Energised after an inspiring group retreat at the top of Kolsås. Great group members, great weather, great views. Ready for the fun science ahead! @biovitenskap.bsky.social

🏆 Congrats to Anne Dejean, laureate of the 2026 Shaw Prize in Life Science & Medicine, with Hugues de Thé & Zhu Chen, for pioneering work that turned acute promyelocytic leukemia into a >90% curable cancer. 🔗 www.shawprize.org/.../life-sci...

🎉 The CBGR group turns 10! We just celebrated with collaborators, colleagues, friends & family. This milestone belongs to everyone involved; too many to name, but every single one of you made it happen. 🙏 Here's to the next 10 years! 🥂 @uio.no @nordicembl.bsky.social @ncmbm.bsky.social

Can cells remember being starved, and does that memory change how they behave in the future? This fundamental biological question is investigated by the research project called "Total Recall". It's funded with 40 million NOK through the "Toppforskere" programme from the Research Council of Norway

Total Recall: Major grant to uncover how cells remember starvation - Department of Biosciences

A team of researchers from the University of Oslo has been awarded 40 million NOK from the Research Council of Norway to investigate a fundamental biological question: Can cells remember being starved...

mn.uio.no

Excited to share that our latest research has been published in @narjournal.bsky.social Read the article here: academic.oup.com/nar/article/... Congratulations to Patrizia Nothnagel and many thanks to all people involved including Nolwenn Briand, Bjørn Steen Skålhegg and @amathelier.bsky.social.

🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟 Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.

I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾 👉 rdcu.be/ezA5o

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells

Nature Communications - Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte...

rdcu.be

We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo

Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

jobbnorge.no

Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest! www.biorxiv.org/content/10.1...

Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization

A remarkable transition during murine development is the progression from the 1-cell embryo to the 2-cell stage, accompanied by the activation of a specific set of embryonic genes, epigenome reprogram...

biorxiv.org

We’re Hiring! I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.

This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming. www.biorxiv.org/content/10.1...

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes

Epigenetic regulation is a key determinant of adipocyte fate and function, conferring phenotypic plasticity to adipose tissue in response to metabolic and thermal challenges. To understand the spatiot...

biorxiv.org

Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪 plos.io/3DRtAEW

Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue. www.tandfonline.com/doi/full/10....

Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue

Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue...

tandfonline.com

My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social

Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social Stay tuned!

Anthony Mathelier@amathelier.bsky.social · 2y ago

We are #hiring a postdoc to study the epigenetic imprinting of cell fate during adipogenesis. Cool interdisciplinary project to analyze ChIP-seq, ATAC-seq, Hi-C, and CAGE. The postdoc will be co-supervised by @chymkowitchlab.bsky.social and me. Spread the word! www.jobbnorge.no/en/available...

As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics. Stay tuned for more updates and details about these positions! @chymkowitchlab.bsky.social www.mn.uio.no/ibv/english/...

Funding to Research on Epigenetic memory - Department of Biosciences

Pierre Chymkowitch at the University of Oslo is awarded 12 million NOK by The Norwegian Research Council, to investigate how SUMOylation influences epigenetic stability and could prevent diseases like...

mn.uio.no

Oslo skeeps. We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data." You can also book a time to meet him. More info at www.mn.uio.no/bils/english...

Dr. Michael Hoffman - Bioinformatics in Life Science – BiLS

Dr. Michael Hoffman, Chair of the Computational Biology and Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, and Associate Professor at the Department of Medical ...

mn.uio.no

Three more days to register and submit your abstract for the upcoming TriRhena Gene Regulation Club. #epigenetics

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 2y ago

The next TriRhena Gene Regulation Club takes place at IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers. 📅 5 Feb. 2025 | 14:00 🎟️ Free entry, registration required ✍️ Register by: 24. Jan. www.ie-freiburg.mpg.de/gene-regulat...

Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!

EMBL Events@events.embl.org · 2y ago

📣 #EMBLSingleMolecule is open for registrations! Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍 👉🏼 s.embl.org/grg25-01-bl 📅 15 – 18 July 2025 📜 Submit your abstract by 8 April!

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Many workplaces have parties or team meals to celebrate the end of the working year, but some show true appreciation by cultivating group traditions. Nature asked group leaders to explain these, and how they thank colleagues for their hard work. #AcademicSky

How to thank your lab mates: eight ways to show gratitude at the end of year

Alongside secret Santas and seasonal parties, many laboratories develop traditions to show appreciation to colleagues — from sweets and mulled wine to quizzes and ice-skating trips.

go.nature.com

6️⃣0️⃣ Marie Skłodowska-Curie (1867-1934) 🇵🇱🇫🇷 #womeninSTEM The most famous scientist in the world. 1st woman professor at Sorbonne, only woman to win the Nobel in 2 different fields. During WWI, she invented a mobile X-ray unit that could travel to the battlefront. www.nobelprize.org/womenwhochan...

Congratulations, Pierre @chymkowitchlab.bsky.social. It's a fantastic news indeed! I look forward to continuing to collaborate with you on this great project. Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!

Chymkowitch lab@chymkowitchlab.bsky.social · 2y ago

A sincere thank you to everyone who contributed to this achievement, including collaborators @uio.no — @amathelier.bsky.social, Jorrit Enserink, Philippe Collas, Nolwenn Briand, Kari Rygg and Magnar Bjørås — as well as Stéphanie Le Gras and Bernard Jost at IGBMC, BRIC and @univbordeaux.bsky.social

Very exciting; I strongly recommend!

Boris Lenhard@borislenhard.bsky.social · 2y ago

A PhD position in computational genomics is open in our group at Imperial/MRC LMS! 🌟 Join the DANIO-ReCODE Doctoral Network and work on gene regulation, evolution, development, and tissue regeneration. Open to all (except those residing in the UK in the past year). Deadline: 8 Jan 2025. t.ly/fDdDW

🎄 What a fantastic Christmas gift! Our #FRIPRO application on the regulation of epigenetic fate by #SUMOylation has been awarded 12MNOK by the Research Council of Norway!

Thousands of people have donated to rebuild Notre-Dame de Paris, including me. But there are hundreds of heritage sites that deserve our attention. Why not make small donations to support projects like this surprising pagoda in the heart of France? www.fondation-patrimoine.org/les-projets/...

Pagode du Petit Jonas à Ambazac

Aujourd'hui très délabrée, la pagode du Petit Jonas va faire l'objet d'une campagne de restauration globale, dans le cadre de la redynamisation d'une base de loisirs entreprise par la commune d'Ambaza...

fondation-patrimoine.org

Superb story studying obesity from an epigenetic memory angle rdcu.be/d2Jun

Adipose tissue retains an epigenetic memory of obesity after weight loss

Nature - Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially...

rdcu.be

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

A superbe afternoon sun over the Oslo fjord during the retreat of the BMB section. Thanks to all speakers and poster presenters for their contribution 👏👍 @biovitenskap.bsky.social

@arnaudkr.bsky.social and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at EMBL while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there! July 15-18 www.embl.org/about/info/c...

Arnaud Krebs@arnaudkr.bsky.social · 2y ago

New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL