Great to share our recent review, written with @niclag.bsky.social and @danielthiele1.bsky.social @monashuniversity.bsky.social #monashBDI The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...

The evolving biology of T cell memory: A dynamic continuum of function and persistence

Advances in technology continue to refine our understanding of CD8 T cell memory, with major implications for next-generation vaccines and therapies.

science.org

#Science #Immunology turns 10 years old this month! We celebrate w/ a Special Issue on immune #memory! Check out our 3 outstanding Reviews by Maziar & Kaufmann; @sjturn.bsky.social, Thiele, & @niclag.bsky.social; & @maurogaya.bsky.social & @kimljacobson.bsky.social out this week! scim.ag/448rEkV

A new #ScienceImmunology study in mice showcases a vaccine adjuvant that can induce protective immunity against herpes simplex virus 2 (HSV-2) infections without causing excessive local inflammation. https://scim.ag/3Skm7oG

Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes

A chemokine–nucleic acid nanoparticle adjuvant elicits protective mucosal immunity against genital herpes simplex virus 2 infection in mice.

scim.ag

Scientists in Dr. @davidraulet.bsky.social's lab at @ucberkeleyofficial.bsky.social have shown that removing tumor Tregs unleashes NK cell responses to control cancers, including MHC I–deficient tumors. 📄 Read the paper: https://bit.ly/4uoezPs 🎙️ Tune in: https://bit.ly/4f2ci85

Happy to announce publication of our first therapeutic mRNA-LNP paper! In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Science Immunology www.science.org/doi/10.1126/...

In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.

science.org

To mark World #Malaria Day, here are 2 recent Science #Immunology papers highlighting cutting-edge malaria research! Nideffer & al. (2025) scim.ag/4izhn63 Gao & al. (2025) scim.ag/4hN5vOY

So excited to share our new @science.org podcast limited series The Normals! Out now!! Listen here: www.science.org/content/podc...

We wanted to put over a decade of advances on the immunology surrounding fetal Zika infection in context in our review "Immune mechanisms of congenital Zika syndrome" @sciimmunology.bsky.social. So happy to see it's #openaccess! www.science.org/doi/10.1126/...

Immune mechanisms of congenital Zika syndrome

This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.

science.org

The January 2026 issue of #ScienceImmunology is out! This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu

Science has named the seemingly unstoppable growth of renewable energy worldwide as the 2025 Breakthrough of the Year. Learn more about this year's #BOTY and other big advances in science: https://scim.ag/493Tpgx

#Science #Immunology will be sponsoring a prize for the best poster presentation! The abstract deadline is fast approaching though, so don't delay! I hope to see many of you in marvelous Ghent this coming March!

Science Magazine@science.org · 8mo ago

In partnership with @vibtrainconf.bsky.social, #ScienceImmunology is organizing #Type2Immunity26 in Ghent 9–10 March 2026, bringing together leaders in the field of #Type2Immunity. Check out our lineup here: vibbio.tech/3UwmTNk 🗓️15 DEC: Travel grant deadline 🗓️8 JAN: Abstract deadline

In #Science #Immunology Bali Pulendran's lab at @stanfordmedicine.bsky.social tests 5 different #LLM models to see how well they can accelerate #vaccine #research in combination with human creativity. www.science.org/doi/10.1126/... 🧪🧫🥼💻

Assessing AI’s cognitive abilities for scientific discovery in the field of systems vaccinology

LLMs assessed with “The Creation Game” show promise in aiding systems vaccinology discovery while remaining human dependent.

science.org

This week in #Science #Immunology, Lambrecht & Hammad labs (@viblifesciences.bsky.social) use #Danish Nat'l Patient & Prescription Registries + mouse models to show that maternal #allergy & neonatal #RSV infection synergize via FcR-mediated allergen uptake to drive development of early life #asthma!

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life

Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.

science.org

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

science.org

To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025! bit.ly/SciImm_free

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

Inhibitory immune checkpoints in cancer immunotherapy

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

science.org

That time I was subject of scientific study, and not an editor.....🏃‍♀️🧪

Christie Wilcox@nerdychristie.bsky.social · 11mo ago

In this edition of #ScienceAdviser, Science Immunology Senior Editor @cnfogg.bsky.social talks about how her love of running led her to be the subject of science—rather than the editor of it. Plus more of the best from @science.org and science: www.science.org/content/arti... 🧪

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/... @sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...

science.org

Sternberg Lab@sternberglab.bsky.social · last yr.

1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)! You can submit your abstracts here: iuis2025.org/abstracts/ I hope to see many of you this August in beautiful Vienna!!! #Immunology #Science2025 #CallForAbstracts #IUIS

Abstracts - IUIS 2025

ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...

iuis2025.org

Happy World #DayofImmunology!

Seth Thomas Scanlon@immunoeditor.bsky.social · last yr.

Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!! First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸 www.science.org/doi/10.1126/...

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses

Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

science.org

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels. Read about this study and more: scim.ag/4j3gx2A

It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB www.science.org/doi/10.1126/...

Immunopathology in human tuberculosis

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

science.org

New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

scim.ag

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!

Dynamic STING repression orchestrates immune cell development and function

Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

science.org

The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production. www.science.org/doi/10.1126/...

Check out the paper below with its related Perspective in @science.org Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

science.org