@biorxivpreprint.bsky.social IFNG-producing self-reactive CD4+ T cells drive autoimmune adrenalitis in a mouse model of Addison's disease www.biorxiv.org/content/10.1...
Kilian Schober
@kischober.bsky.social
MD Microbiology & Virology. Understanding & Engineering Human T Cell Immunity in Erlangen, Germany (www.schoberlab.de). Cycling. BVB. Cinema. Family.
Today is the last day of our postdoc @nipagh.bsky.social who returns to Copenhagen after a 3-year fellowship. Stay tuned for his spectacular EBV T cell story in MS, which we will share as a preprint soon. Thanks, Nikolaj, and all the best!! @fau.de
Eight days ago, our ex PhD student @katharinakocher.bsky.social received a prize for one of three best dissertations at the Faculty of Medicine @fau.de. It was part of a ceremony for all doctorates and jubilees of the past year, a wonderful event. Congrats, Katharina!
The finding helped establish the idea that an oncogenic herpesvirus can remain latent rather than continuously producing virions. rdcu.be/fupdl
Presence of EB Virus Nucleic Acid Homology in a “Virus-free” Line of Burkitt Tumour Cells
Nature - Presence of EB Virus Nucleic Acid Homology in a “Virus-free” Line of Burkitt Tumour Cells
rdcu.be
Elon Musk’s cuts to U.S.A.I.D. led to some 700,000 deaths, Atul Gawande says. www.newyorker.com/news/the-new...
The Human Cost of DOGE’s War on U.S.A.I.D.
Elon Musk, Donald Trump, and the “public man-made death” that they’ve caused.
newyorker.com
Looking forward to presenting our latest findings on dual receptor T cells!
Deutsche Gesellschaft für Immunologie e.V. (DGfI)@dgfi-org.bsky.social · 4w agoThe next Immune Alliance Lecture is on Wednesday, 15 July, 9 am in Germany / 4 pm in Japan. 😊 You are cordially invited to attend: dgfi.org/immune-allia... ... online and free of charge. @zielinskilab.bsky.social @efis-immunology.bsky.social @iuis-online.bsky.social @dgfi-yi.bsky.social
Great to share our recent review, written with @niclag.bsky.social and @danielthiele1.bsky.social @monashuniversity.bsky.social #monashBDI The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...
The evolving biology of T cell memory: A dynamic continuum of function and persistence
Advances in technology continue to refine our understanding of CD8 T cell memory, with major implications for next-generation vaccines and therapies.
science.org
Thrilled to share our newest study led by @categraca.bsky.social and @yannick-alexandre.bsky.social published in @cp-immunity.bsky.social Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳 url.au.m.mimecastprotect.com/s/NE67C6X1Py...
B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection
B cells are highly abundant lymphocytes and central players in humoral immunity. Although T cells are well known to support humoral responses, how B c…
url.au.m.mimecastprotect.com
Doherty Institute@thedohertyinst.bsky.social · last mo.New research reveals B cells do much more than produce antibodies - they also help activate and sustain T cells to fight chronic infections, like cancer or auto immune diseases. https://bit.ly/4wdXKrw
We are looking for a PhD student to join our lab in Erlangen (www.schoberlab.de). Excited about human immunology, T cells, viruses, high-throughput screens, and mechanistic questions? Apply here: www.karriere.uk-erlangen.de/en/job/phd-s... Please share with candidates.
“It’s just a microscopic water droplet surrounded by a fatty membrane and stuffed with chemicals and snippets of DNA encoding a mere 36 genes. But it’s also arguably the closest researchers have come to building a living cell from scratch.”🧪 My story in @science.org on a fascinating preprint:
Lab-created ‘SpudCell’ marks ‘stunning’ step toward building life from scratch
A synthetic cell can now grow and divide—but it’s still far from alive
science.org
What are our blind spots in human T cell immunology? In "Current Opinion in Immunology", M. Hiltensperger and I argue that we lack a coherent understanding of epitope-specific responses in secondary lymphoid organs. www.sciencedirect.com/science/arti... Grazie, Marco & Matteo, for the invite!
A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs
The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, pheno…
sciencedirect.com
An interesting finding: for medical questions, specialized large language models might perform worse than general-purpose LLMs such as chatGPT: www.nature.com/articles/s41...
General-purpose large language models outperform specialized clinical AI tools on medical benchmarks - Nature Medicine
In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.
nature.com
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity @kischober.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity
Advances in high-throughput sequencing, single-cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation o...
onlinelibrary.wiley.com
"The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity." My personal perspective on TCR (repertoires). Immunological Reviews: onlinelibrary.wiley.com/doi/epdf/10.... This is part of a special issue with contributions from great TCR colleagues.
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity
Advances in high-throughput sequencing, single-cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation o...
onlinelibrary.wiley.com
"Integrating complementary approaches reveals antigen-reactive CD4+ T cell states after SARS-CoV-2 vaccination" New paper from our lab, just out in @cp-iscience.bsky.social. It is, for the time being, our last work on SARS-CoV-2 T cell responses. www.cell.com/iscience/ful...
Integrating complementary approaches reveals antigen-reactive CD4+ T cell states after SARS-CoV-2 vaccination
Therapeutics; Immunology; Virology
cell.com
Ein Team von Studierenden der FAU hat bei der diesjährigen Asian Supercomputer Challenge einen herausragenden Erfolg erzielt. Das Team „FAUltier“ überzeugte beim Finale des weltweit größten studentischen Supercomputerwettbewerbs als bestes internationales Team. www.fau.de/2026/06/news...
FAU-Team gewinnt bei weltweit größtem Studierenden-Supercomputerwettbewerb
Team „FAUltier“ überzeugt bei der Asian Supercomputer Challenge mit Spitzenleistung…
fau.de
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
reeserichardson.blog
@biorxivpreprint.bsky.social A scRNA-seq atlas of chronic inflammatory skin diseases www.biorxiv.org/content/10.6... isd-atlas.derma.meduniwien.ac.at
As global health budgets tighten, how should countries and policymakers decide which vaccines should be prioritised? While the answer varies depending on geography, context and myriad other factors, researchers have compare 14 vaccines on one crucial metric. Dig into the results: bit.ly/3P6qrXC
What is the spectrum of suspected pediatric meningoencephalitis in the era of conjugate vaccines and multiplex PCR diagnostics? 🧵 Our study is now published open access in Infection link.springer.com/article/10.1... 1/4
Pediatric meningoencephalitis in the molecular diagnostic era: epidemiological insights from 1198 suspected cases in Germany between 2016 and 2024 - Infection
Purpose The epidemiology of suspected pediatric meningoencephalitis has changed in the era of conjugate vaccines and multiplex PCR. Updated epidemiologic data are needed to adapt diagnostic and therap...
link.springer.com
Should all children be vaccinated against influenza? Most pediatric infectious disease specialists would probably say yes — but universal influenza vaccination for children is still not generally recommended in Germany and many other European countries.
A new Lancet study just reported the primary mortality analysis from the RTS,S malaria vaccine implementation programme in Ghana, Kenya, and Malawi. The verdict after 46 months is 1 in 8 deaths averted in eligible children, a very important outcome. www.thelancet.com/journals/lan...
Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
Introduction of the RTS,S malaria vaccine in routine immunisation programmes was associated with a significant reduction in mortality in young children, averting about one in eight deaths, in areas wi...
thelancet.com
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery - @stanfordmedicine.bsky.social go.nature.com/3QWMRet
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery - Nature Biotechnology
A deep-learning method predicts T cell receptor specificity and disease-associated antigens.
go.nature.com
Join us in Copenhagen, Denmark, for #HCVFlavi2026! The international conference on Hepatitis C Virus, Flaviviruses and Related viruses. 🗓️ Dates: September 14–17, 2026 ⏳Abstracts: May 12, 2026; Early Registration: June 14, 2026 hcv-flavi2026.org #Antivirals #HCV #Flavivirus #Vaccines
Exciting new work from Aaron Bodanksy and Joe DeRisi and colleagues on finding antigen-specific B cells and T cells in ROHHAD, a rare pediatric neuroendocrine disorder www.biorxiv.org/content/10.6...
biorxiv.org
I've spent yesterday and today talking to researchers across the globe trying to understand the hantavirus outbreak aboard the cruise ship MV Hondius. My story in @science.org is here (and some threaded thoughts coming): www.science.org/content/arti... 🧪 #IDsky
Cruise ship’s hantavirus outbreak puts researchers in uncharted territory
Questions about the culprit virus and its route of spread remain as health officials make plans for stranded passengers
science.org
🟡 New from @kischober.bsky.social in Nature Immunology! Long-lived T cell memory after yellow fever vaccination depends on an early metabolic "standby mode" — confirmed also after COVID-19 vaccination. The most durable immune cells aren't the most active. Less sprinter, more marathon runner.
A compelling shift toward tissue-centric immunity: lymphoid niches don’t just initiate responses—they time and constrain them. Brilliant now work from Lukas Altenberger shows that timing of initiating and terminating immune response are equally important. www.science.org/doi/10.1126/...
Lymphoid tissue chemokines limit priming duration to preserve CD8+ T cell functionality
The generation of effector CD8+ T cells (TEFF) requires activation of naïve CCR7+ T cells (TN) by dendritic cells (DCs) in lymphoid tissue. How TN-DC interaction duration and signal integration are co...
science.org
Genome pioneer Craig Venter dies: he transformed science by redrawing the boundaries of biology — sequencing DNA at unprecedented speed, engineering synthetic life and charting ocean microbes www.nature.com/articles/d41...
