Good news! Our paper (with @aabiddanda.github.io @sarahaj34.bsky.social @codushlaine.bsky.social and Priya Moorjani) is now officially online! www.science.org/doi/10.1126/...

Recovering signatures of archaic hominin introgression using ancestral recombination graphs

Admixture between modern humans and extinct hominins has shaped the genomes of present-day individuals, but reconstructing this history has been constrained by the scarcity of archaic samples and unad...

science.org

Yulin Zhang@yulinzhang.bsky.social · 6mo ago

Have you ever wondered how many archaic populations contributed DNA to modern humans? We know about Neanderthals and Denisovans, but the fossil and genetic evidence suggests a much more complex history! www.biorxiv.org/content/10.6...

Just in case you need some good news today: researchers at U of W have figured out how to turn plastic waste into acetic acid (primary ingredient in vinegar) using the sun. This has the potential to really help us reduce plastic waste. uwaterloo.ca/news/media/w...

Have you ever wondered how many archaic populations contributed DNA to modern humans? We know about Neanderthals and Denisovans, but the fossil and genetic evidence suggests a much more complex history! www.biorxiv.org/content/10.6...

We’re excited to share a new article from @insitro.bsky.social (first author @zmccaw.bsky.social) in @ajhgnews.bsky.social, introducing a summary-statistic-based implementation of the COding-variant Allelic Series Test, COAST-SS: www.sciencedirect.com/science/arti...

A scalable framework for identifying allelic series from summary statistics

Genes where a dose-response relationship exists between functionality and phenotypic impact are appealing therapeutic targets, as the effects of pharm…

sciencedirect.com

We’re @ #ASHG to share our work that uses high-content phenotypic data, genetics & AI/ML to unblock new biology. @sominenihk.bsky.social presents work to identify a key gene as a clinical driver of #MASLD @twsoare.bsky.social presents on #AMD & how we use OCT scans to better predict disease risk

Oh to be a little Tardigrade scratching its back on a bubble. 🫧🐻🧪

Our paper out today: 50,000 years of evolutionary history of India: Impact on health and disease variation: Cell www.cell.com/cell/fulltex...

50,000 years of evolutionary history of India: Impact on health and disease variation

A genomic study of 2,762 individuals from India offers important insights into the genomic diversity and evolutionary history of the subcontinent and highlights the extensive genetic variation, gene f...

cell.com

Great start to #FOGBoston with a talk from Eric Green showing the remarkable ascent of genomics since 2003. Pretty shocking to hear how much damage has been done to public science institutions this year.

There is no rationale for removing every member of the Advisory Committee for Immunization Practices (ACIP) and replacing them, except for RFK Jr. to appoint members who spread disinformation. I am *disgusted* by Republicans for letting this happen to the U.S. abcnews.go.com/amp/Health/r...

RFK Jr. says he is removing all 17 members of CDC's vaccine advisory committee

HHS Secretary Robert F. Kennedy Jr. announced on Monday he is removing all 17 members of the Centers for Disease Control and Prevention’s vaccine advisory committee.

abcnews.go.com

In a world of Matts, be a Derek.

Survey from the global alliance for open science - Impact of Public Data Resources on Biopharma and Life Sciences Workflows: www.surveymonkey.com/r/BioITPubli... Worth filling in!

The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene". But only slightly less well-known is this: consider the colocalized phenotypes. That is, a genetic variant seldom disrupts exactly one phenotype. What else does tugging on that thread do?

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

1. For the past thirty years I've had the best job in the world. 
I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

This is sad not just for genomics in the US, but across the world: Eric has been an incredibly effective global champion for the power of genomics and the impact of genomic medicine.

Matthew Herper@matthewherper.bsky.social · last yr.

Eric Green is out as head of National Human Genome Research Institute www.statnews.com/2025/03/17/t...

Today insitro announces an exciting new collaboration with insighteyehub.bsky.social at Moorfields Eye Hospital, London, through the development of a novel #AI foundation model to identify and to support #drugdiscovery. Learn more: www.businesswire.com/news/home/20...

Lungfish xkcd.com/3064

Wow. "NIH" canceled my co-mentored (with Dave Sulzer) PhD student's F31 funding. His work is on understanding the genetics and neuroscience of language learning disorders. F31 provides no indirect $ to Columbia, just pays his salary. Not that it should matter, but he's an American citizen. W.T.F.

Is pubmed down/gone? This can’t be right..

Our work describing a deep dive into the use of ratio traits in GWAS, and things to watch out for!

Tom Soare@twsoare.bsky.social · 2y ago

Excited to share a new paper from @insitro.bsky.social (first author @zmccaw.bsky.social ) in @hggadvances.bsky.social vances.bsky.social on scrutinizing the practice of using a ratio trait (numerator / denominator) for GWAS. www.cell.com/hgg-advances...

The US government has been turned over to a group of extraordinarily ignorant people, and they are working to destroy science in this country. Cutting over half the NSF budget would save < 0.1% of the federal budget, but do incalculable harm. Simply heartbreaking. arstechnica.com/science/2025...

White House budget proposal could shatter the National Science Foundation

“This kind of cut would kill American science and boost China.”…

arstechnica.com

Yesterday in Nature. A new place for science 👌

You know it’s a good thing when you are back to finding cool new science through social media on a Friday evening :)

Just out, makes some important points and well worth a read.

Guidance for human genome data collection, access, use and sharing

The WHO’s new document outlines a comprehensive set of globally applicable principles designed to guide stakeholders in the responsible collection, use, and sharing of human genome data. This document...

who.int