Craig Gedye

@craiggedye.bsky.social

Medical oncologist, physician/scientist #cansky #oncosky #clinicaltrials #kidneycancer #braincancer #prostatecancer #btsm #pcsm #kcsm @anzuptrials.bsky.social @COGNOtrials @iconcancercentre.bsky.social Posts my opinion only. #FCOI http://bit.ly/3xKTdPm

Fantastic to have this critical advice for older people with cancer - thank you @crisbergerot.bsky.social @bogda-koczwara.bsky.social and team

Cris Bergerot, PhD@crisbergerot.bsky.social · 11mo ago

🚨New @ascocancer.bsky.social Guideline Alert! 🌍 Honored to have worked alongside #EnriqueSoto & cols in developing this guideline Check out the latest recommendations on GA, designed to improve care worldwide 📄Full guideline ascopubs.org/doi/pdf/10.1... 🎙️Don’t miss the accompanying podcast!

Question remains, is the abscopal effect real? Or is #RT just additive? Certainly evidence for modifying TME, intriguing data for WNT-mt patients when adding #radiotherapy to #PD1 #immunotherapy, but the idea of #RT being a 'vaccine', expanding the immune repertoire, is shown in just 1-2 patients.

Nature Cancer@natcancer.nature.com · last yr.

🚨ARTICLE now published at Nature Cancer ! ✏️By Valsamo Anagnostou and colleagues 'Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer' 🔗 www.nature.com/articles/s43...

Two opinions that to my surprise are either unpopular or not widely held: 1. The control arm of a randomised trial should be best standard of care. 2. A PFS benefit against an inactive comparator is not a major advance, if progressive disease is required for eligibility.

Tremendous insights with immediate patient impact; using genomic data we can collect routinely from today's patients, we may be able to predict upfront resistance, rather than subject people to 3-4 cycles of chemo, and we might also be strategic if we know people have sensitive cancers - bravo!

Geoff Macintyre@gmaci.bsky.social · last yr.

🚨Chemo treatment upgrade!🚨 Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies www.nature.com/articles/s41...

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer

Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

nature.com

🚨 Public consultations now open: help shape how medicine information is shared with patients. We are reviewing the template used for EU package leaflets. Have your say on how to make them more understandable and relevant to patients. 🔗 Learn more & share your input: europa.eu/!TCm47q

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Great piece from Lancet Global Health on democratising clinical trials research to strengthen primary healthcare, relevant to ALL healthcare. Every healthcare intervention is a clinical trial of n = 1; why not learn from every patient, every clinician?

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00513-8/fulltext

Psych. Science just published a paper showing that the "warm glow" of donations can reduce depressive symptoms (d = [0.19, 0.46]). Most impressively, "micro" donations (one Chinese cent, or $0.0014) appear sufficient to trigger these large effects. Big if true? Let's dive in.