But most of all, I remember his kindness, humor (sometimes sharp) and generosity.

Daan Noordermeer lab@daannoordermeerlab.bsky.social · last mo.

It’s with great sadness that I hear about the passing of Frank Grosveld. I did my PhD in the dpt he was directing. His scientific vision, involvement in all projects and capacity to create a vibrant international community were truly inspiring and one of the reasons why I am where I’m now (1/2)

It’s with great sadness that I hear about the passing of Frank Grosveld. I did my PhD in the dpt he was directing. His scientific vision, involvement in all projects and capacity to create a vibrant international community were truly inspiring and one of the reasons why I am where I’m now (1/2)

Lluis Montoliu@lluismontoliu.bsky.social · last mo.

Frank Grosveld, born in 1948, passed away last Friday. He was a colossal scientist in the transcriptional control of gene expression during development and helped us understand the complex regulation of beta-globin genes. His work will remain as a reference. May he rest in peace.

I have been thinking since yesterday about why I find the 1% thing so, so disturbing. It's a visceral reaction of 'just no', which goes beyond the general yuck towards the enshittification of/via AI. I have finally put my finger on it: it is the feeling you get when

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

Cis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh...

biorxiv.org

📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS

📣📣 Deadline approaching 📣📣 (Please re-post) If you are thinking of starting (or moving) your lab, do not miss the opportunity to apply to join us at the @i2bcparissaclay.bsky.social Diversity of topics, interdisciplinary environment and excellent platform support! Recommended!

@i2bcparissaclay.bsky.social · 5mo ago

We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology #CellBiology #ComputationalBiology #TeamLeaders#I2BC

Spring has arrived on campus

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!

The EMBO Journal@embojournal.org · 5mo ago

Condensin loop extrusion properties, roadblocks, and role in homology search @aurelepiazza.bsky.social et al show yeast condensin unidirectionally extrudes long chromatin loops & contributes to biasing donor selection during recombinational DNA break repair link.springer.com/article/10.1...

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

Join IGH as Group Leader - IGH

The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

igh.cnrs.fr

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology #CellBiology #ComputationalBiology #TeamLeaders#I2BC

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders! Announcement here: www.i2bc.paris-saclay.fr/join-i2bc/te... Open to early career scientist from anywhere or mid-career already in France. Please RB!

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Nature Biotechnology@natbiotech.nature.com · 6mo ago

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal

Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

link.springer.com

New paper from the Feil lab! congratulations🍾👏 Great thread below ⤵️ @agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support @cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social #epigenetics

Daan Noordermeer lab@daannoordermeerlab.bsky.social · 7mo ago

🔔 New paper alert 🔔 www.nature.com/articles/s41... Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)

🔔 New paper alert 🔔 www.nature.com/articles/s41... Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)

Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41... Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488

We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

nature.com

This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy

bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 7mo ago

Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇

It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct