Dani León-Periñán
@danilexn.bsky.social
Cells talk; I build tools to listen to them Computational biologist • Occasional composer and pianist • he/him Opinions are my own.
Spain doesn’t need to make business with a country led by a pedophile. We’ve been around more than 3000 years, and we will be around for another 3000. We will be super happy when the US empire falls, soon. elpais.com/internaciona...
Última hora del ataque de EE UU e Israel contra Irán, en directo | Trump anuncia que cortará todo el comercio con España por ser un aliado “terrible”
Sánchez hará declaraciones al respecto mañana en La Moncloa | Bruselas dice que defenderá la “plena” protección de los intereses de la UE | Aterriza en Barajas el vuelo con los más de 175 españoles r...
elpais.com
This is such an exciting project, join us!
Nikos Karaiskos@nukappa.bsky.social · 5mo ago🚀 We're looking for people to join Malva! 🧬 @danilexn.bsky.social Malva is the first search engine for single-cell genomics: we process massive amounts of sequencing data to enable ultrafast analysis of millions of cells. (1/4)
🚀 We're looking for people to join Malva! 🧬 @danilexn.bsky.social Malva is the first search engine for single-cell genomics: we process massive amounts of sequencing data to enable ultrafast analysis of millions of cells. (1/4)
SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues. www.nature.com/articles/s41...
‘A bombshell’: doubt cast on discoveries of #microplastics throughout human body, from brain to blood, arteries to testes Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’ Story by me www.theguardian.com/environment/...
‘A bombshell’: doubt cast on discovery of microplastics throughout human body
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
theguardian.com
MAGA: The USA economy is 40% larger than all of Europe. Close your borders. EU: Buddy, inflated economy does not count. GDP does not count when people cant even pay their healthcare.
Members of Congress: stop posting online and APPEAR, PHYSICALLY on the steps of the Capitol to decry this unconstitutional violation of domestic & international law. SHOW THE PEOPLE the level of danger we are facing as a country. @housedemocrats.bsky.social @senatedemocrats.bsky.social
not safe for non-america countries to have a president these days. trump would've done this to greenland already if anybody in the administration could figure out who the main guys are in a parliamentary government
Venezuela hoy da la imagen del mundo que traen las fuerzas reaccionarias: agresiones militares ilegales, la razón de la fuerza bruta, el capricho imperial como norma. Un mundo de siervos en el que nadie esté a salvo.
Who would’ve thought that the pedophile that encouraged an assault to the Capitol could kidnap the president of another sovereign nation? Wow mind blowing stuff.
The problem is thinking that US is the world’s number one superpower. The world’s number one superpowers are Europe and China. They’ve been for thousands of years and they’ll still be for another thousand. US is just a third-world country with Gucci outfits.
James Ball@jamesrball.com · 7mo agoKidnapping the leader of a foreign state without any declaration of war and announcing it via social media is full-on rogue state stuff. From the world’s number one superpower.
Lourd est le parpaing des Trump, Poutine, Netanyahou et consorts sur la tartelette aux fraises du droit international.
Repeat after me: GENE 👏 EXPRESSION 👏 PROFILING 👏 DOES 👏 NOT 👏 A 👏 VIRTUAL 👏 CELL 👏 MAKE 👏
Today is a big day. After many years of work, I’m excited to finally share a paper describing a novel approach to identifying potential breakthroughs in biomedical research, up to twelve years before the breakthrough itself occurs. 1/15
🧮 Just out in Bioinformatics Advances: “FroM Superstring to Indexing: A space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT)” Full article available: https://doi.org/10.1093/bioadv/vbaf290 Authors include: @pavelvesely.bsky.social, @brinda.eu
History will remember Claudia Sheinbaum as the idiot who demanded a government to say sorry for stuff that happened 500 years ago, while taking selfies with a nazi-pedophile. elpais.com/deportes/mun...
El sorteo del Mundial de Fútbol 2026, en directo | Uruguay, Arabia Saudí y Cabo Verde se enfrentarán a España en la fase de grupos del Mundial
La selección de Luis de la Fuente cae en el grupo H, que disputará sus partidos en Miami, Atlanta, Houston y Guadalajara | El partido inaugural será entre México y Sudáfrica el próximo 11 de junio | L...
elpais.com
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine. www.tagesspiegel.de/berlin/senat...
Senat will 12,5 Millionen Euro investieren: NFL kommt 2025 für ein Spiel nach Berlin
Die nordamerikanische Football-Liga NFL wird 2025 ein Spiel in Berlin austragen. Bis 2029 könnten zwei weitere Folgen. Die Kosten dafür sind hoch. Das Land muss trotz Haushaltskrise Millionen investie...
tagesspiegel.de
This is pure bullshit. You don’t need to run 200 LLM agents for >8 hours to do DE, GSEA and generate a couple of heatmaps. And if you do, just spend 2 weeks learning bioinformatics and you won’t need to give money to a company selling snake oil. arxiv.org/pdf/2511.02824
arxiv.org
🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch! 📅 Starting date early 2026, with some flexibility. 🙏Please, RT!
My humble advice to 10X: Why don’t you invest a bit more on R&D and a little bit less on legal? www.genomeweb.com/business-new...
10x Genomics to Sue Illumina Alleging Infringement of Single-Cell, Spatial Patents
The lawsuits are the latest IP battle for 10x, which has sued just about every competitor it has faced in both the single-cell and spatial transcriptomics markets.
genomeweb.com
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
What is RNA velocity in situ? ChatGPT kept getting it wrong... So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0 #AcademicSky
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
YouTube video by Prof. Jean Fan
youtu.be
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
Ca n'est pas si souvent, un article publié dans Nature met ma communauté à l'honneur (la bioinformatique des séquences). Je vous raconte ? www.nature.com/articles/d41...
‘Google for DNA’ brings order to biology’s big data
MetaGraph compresses vast data archives into a search engine for scientists, opening up new frontiers of biological discovery.
nature.com
How does a “universal” transcription factor evolve to do species-specific jobs? Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes. Read it here 👉 www.biorxiv.org/content/10.1... #MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
biorxiv.org