Nice write up by Ian Demsky about our work as part of the NIH MORPHIC Consortium together with @studerl.bsky.social, @danweihuangfu.bsky.social, and Ting Zhou labs. www.mskcc.org/news/morphic...

New preprint with @kanishkadey.bsky.social's group. We asked: can you connect what happens to beta cells under nutrient stress in a dish to T2D genetics and dietary patterns in ~46K people? We built a "dish-to-biobank" framework to find out. #StemCells #UKBiobank www.biorxiv.org/content/10.6...

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes

Type 2 diabetes (T2D) arises from genetic susceptibility and chronic metabolic stress, but whether these converge on shared molecular programs in human populations remains unclear. Here, we develop a ...

biorxiv.org

Thrilled to share that our paper is now published Developmental Cell! 🧬🎉 Spearheaded by Xian Zhang and Wilfred Wong, we built a human stem cell-based organoid system to model PDAC initiation. A huge team effort with our collaborators Rohit Chandwani and Christina Leslie. tinyurl.com/5ezyh3fa

Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

Zhang et al. develop hPSC-derived pancreatic progenitor organoids that model PDAC initiation and progression. The model reveals that CDKN2A loss is uniquely required for human pancreatic transformatio...

cell.com

Researchers led by Dr. @danweihuangfu.bsky.social at @mskcancercenter.bsky.social have established a stem cell-derived #organoid model that shows genetic and epigenetic mechanisms driving human pancreatic cancer initiation. 📃 https://bit.ly/4ukl3iB 🎧 https://bit.ly/4tWDOI3

new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q

Human DICER1 hotspot mutation induces both loss and gain of miRNA function

Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...

rdcu.be

As a member of the editorial board for @stemcellreports.bsky.social, I am excited to share that we are looking for submissions in the field of stem cell research! I invite you to submit your work for consideration. invt.io/1bxbz2ji4db @isscr.org #stemcell #DevBio #hPSCs #regeneration

Check out ISSCR's society journal, Stem Cell Reports!

invt.io

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize - News

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...

rockefeller.edu

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose, & treat cancer. bit.ly/3WUiuo1

Congratulations to #MSKPostdoc Denis Torre on being awarded the Damon Runyon Fellowship! 👏👏👏 Keep up the good work! @damonrunyon.org @mskeducation.bsky.social

📢 Interested in #AI + #PrecisionMedicine? The NIH PRIMED-AI program has forecasted several new #funding opportunities — covering AI frameworks, validation centers, academic-industry partnerships & more! 📝 FOAs expected soon — stay tuned & start planning! 🔗 More information: dknet.org/about/dknetn...

Traveling to the @isscr.org meeting in HK soon? Feeling like browsing through important #StemCell work published during the past year on your way there? Take a look at our collection of papers published across @natureportfolio.nature.com during the past 12 months! www.nature.com/collections/...

A year of stem cell and developmental biology

In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...

nature.com

Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells: Stem Cell Reports www.cell.com/stem-cell-re... ‪

Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells

Huangfu and colleagues identified two NANOG enhancers from a CRISPR interference (CRISPRi) screen in hESCs. Heterozygous deletions of either enhancer significantly lowered NANOG expression, reduced hE...

cell.com

Lab hiking at Mount Beacon. Great views of the Hudson, a few detours off-trail (in true scientific spirit), and just the right amount of rain. many thanks to Denis Torre for organizing. A beautiful sendoff for lab members (Jielin Yan and Sharon Adeniyi) soon setting off on their own paths.

🎓 Congratulations to the 14 scientists who graduated from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences (GSK) this year!  Learn more about this year's GSK graduates and their accomplishments: bit.ly/3SGB1T8

Hosted Ben Stanger for a seminar and in addition to a great presentation (I'm expecting that!), I also received a surprise! Thanks @benstanger01.bsky.social

Congratulations to our 2025 graduates! So inspired @carolynbertozzi.bskyverified.social commencement speech. @mskeducation.bsky.social Congratulations to Dr. Jielin Yan and Dr. Samual Kaplan. So very proud of your accomplishments!

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n

One of these studies from @mskcancercenter.bsky.social and the result of the long term commitment to basic stem cell investigation by Lorenz Studer and Viviane Tabar at MSK. Very exciting!

NPR@npr.org · last yr.

Two new studies suggest that Parkinson's disease can potentially be treated with stem cells placed in a patient's brain.

Calling all students in NIDDK relevant disease research fields! 🔬📊 Ready to explore data management, #FAIR data, rigor and reproducibility, and #datascience? The dkNET Summer of Data program offers training to boost your research skills. Apply now! ✨ dknet.org/about/Summer...

exciting news for our scientific community! www.nygenome.org/news-events/...

Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025

Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025

nygenome.org

Can you explain your doctoral research through interpretive dance? The deadline for submissions to the 17th annual #DanceYourPhD competition is this week. Submit by 28 March for a chance to win $2000: scim.ag/4gKMnz9

Congratulations to Dr. Jielin Yan #GSK for successfully defending her PhD dissertation! And a refreshing perspective on a non-monotonic relationship between academic freedom and scientific growth. Check out her preprint here on the discovery of NANOG enhancers www.biorxiv.org/content/10.1....

Tom Maniatis coming in hot in @CellCellPress to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science. And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯 www.cell.com/cell/fulltex...

Safeguarding the future of biomedical science in the United States

NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...

cell.com

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

#ISSCR joined hundreds of biomedical research organizations to urge House and Senate appropriators to support robust funding for NIH & avoid drastic measures that will slow scientific progress and weaken the U.S. research ecosystem. www.isscr.org/isscr-news/t...

The ISSCR Signs on to Coalition Letter in Support of NIH — International Society for Stem Cell Research

The ISSCR joined with Research!America, hundreds of biomedical research organizations, and thousands of private citizens from the U.S. scientific community to urge House and Senate appropriators to av...

isscr.org

I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...

Graduate Reductions Across Biomedical Sciences (2025)

docs.google.com

I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 www.cell.com/cell/fulltex...

A nucleosome switch primes hepatitis B virus infection

A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

cell.com

💊 Drug development relies on understanding gene function. However, we still don’t know what most genes actually do. Excited to be part of the #MorPhiC consortium, working to close this knowledge gap. #ScienceMatters #CRISPR #FunctionalGenomics #iPSC Check out 👇 www.nature.com/articles/s41...

MorPhiC Consortium: towards functional characterization of all human genes - Nature

This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated...

nature.com

Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic. globalnews.ca/news/9793403...

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...