Immune cells are a little obsessed with specific foods! immunologyexplained.aai.org/news/immune-...

Immune Cells Are Picky Eaters! - Immunology Explained

Understanding how the nutrients available affect immune cells can help save and improve lives—from fighting cancer to infectious disease.

immunologyexplained.aai.org

Amazing!!! Macrophages taking little bites from living cells to maintain self-tolerance. Incredible study!!

Amy C Fan (she/her)@amycfanphd.bsky.social · 3mo ago

Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social

We are incredibly proud to announce that 5 AAI members have been elected to the U.S. National Academy of Sciences in recognition of their distinguished achievements in original immunological research. Join us in celebrating this prestigious honor! Learn more: https://ow.ly/x4jM50YS0kj.

Mitochondrial dynamics in macrophages has not been clearly defined before. Super excited to read this!!!

Ronan Kapetanovic@ronankp.bsky.social · 3mo ago

Our work is finally out in Science Immunology ! This was an Amazing collaborative work from all co-authors, in particular the two co-first authors James Curson and Syeda Farhana Afroz . Never give up ! :) www.science.org/doi/10.1126/...

a5R brings the A5 pentagonal geospatial index to R. Equal-area pentagonal cells across 31 resolutions, encoded as 64-bit integers, with millimetre-level precision at the finest scale 🗺️ R package by Hugh Graham; a5 by Felix Palmer github.com/belian-earth... #rstats #rspatial #dggs

This is super cool. Proteins as templates for DNA synthesis. Goes to show how biology confounds are best efforts to apply rigid dogmas!! Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase | Science www.science.org/doi/10.1126/...

Cool paper showing a new moonlighting function of iNOS in macrophages! It apparently binds IRG1 in the mitochondria and NO-independently regulates itaconate production!! Pretty cool stuff! Need to dive into the details but curious if it holds in human macs! www.nature.com/articles/s42...

Wow!

Digital Brain@yourdigitalbrain.bsky.social · 4mo ago

Giant honeybees (Apis dorsata) synchronize thousands of abdomens in a wave to repel hornets from their nest

We integrate H&E and IHC sections (CODA) to generate 3D immune maps of tumors and precancerous lesions in the human pancreas. CODA allows to map very large volumes of tumors at single-cell resolution. More here: www.cell.com/cell-press-b...

Watch this great video that Dr. Ashley Kiemen has made. It shows how we use AI to map individual immune cells in the vicinity of precancerous lesions of the human pancreas (PanINs). More here: www.cell.com/cell-press-b...

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

I think the clocks in UK go back tonight. Or forward. Not sure. Is it forward

A new pre-print from the lab!!! Check out SpotGraphs a simple little R package to explore spatial transcriptomics data using graph tools! www.biorxiv.org/content/10.6...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations" Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations? rdcu.be/e7zx7

Gene regulatory networks: from correlative models to causal explanations

Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

rdcu.be

I'll be heading to IMMUNOLOGY2026™ from April 15–19, 2026!

Register for IMMUNOLOGY2026™ | April 15-19, 2026

The leading annual all-immunology event worldwide!

i.snoball.it

Context is everything in metabolism! This super elegant study on how hexokinase isoforms are conditionally essential depending on culture media and mitochondrial association highlights how much we need to work towards methods that let us probe these phenomena in vivo! rdcu.be/e3xOV

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production

Nature Metabolism - Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer...

rdcu.be

Metabolic control of immune cells impacts every aspect of their function. We show that monocytes transitioning to tissue resident macrophages need DHPS, otherwise monocytes are stalled in an immature state. Super excited to see this story published after a ton of work! rdcu.be/e3wKe

The transition from monocyte to tissue-resident macrophage requires DHPS

Nature - In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.

rdcu.be

This is so cool!! Amazing work expanding single cell metabolomics to thousands of metabolites and hundreds of thousands of cells! Shame you need a custom built mass cytometer to do this 🥲 but hopefully someone is on this to make it widely accessible!

Nature Methods@natmethods.nature.com · 6mo ago

An ion mobility-resolved mass cytometry method enables multidimensional metabolomic profiling of single cells. www.nature.com/articles/s41...

Looking forward to reading this!! Always fascinating how cells fine tune responses to common cytokines.

Nature Cell Biology@natcellbio.nature.com · 6mo ago

☕ @karsten-rippe.bsky.social & co analyse #chromatin accessibility to identify sites that open simultaneously in response to TNF. They discover 2 distinct types of co-accessible regulatory module for controlling the induction of #proinflammatory gene expression. 👉https://rdcu.be/e2WwS bit.ly/3MiB4oH

I can't say I'm surprised by this www.theguardian.com/environment/...

‘A bombshell’: doubt cast on discovery of microplastics throughout human body

Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’

theguardian.com

Holy smokes

Mark A. Hanson@hansonmark.bsky.social · 7mo ago

We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do? arxiv.org/abs/2601.07563 A 🧵 1/n

I've seen some cool gesture-based point cloud controllers. So I noted the JS libraries used and vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via 🖐️ Try it out: jef.works/GestureGraph/

All models are wrong, and yours is useless www.nature.com/articles/s41...

Super proud of Andrei Dorobantu who was named a @society4science.bsky.social #RegeneronSTS scholar for work that he performed in my lab. Only 300 young scientists are selected for this honor. bit.ly/4j6k8Oe

Newfound disappointment: receiving shallow peer reviews that are entirely AI-generated. The whole point is critical feedback from YOU as a real expert. If reviewers are outsourcing to AI, I think we've lost the plot 🤷‍♀️ As an editor, I'm definitely keeping better track of reviewers I can trust...

Join us in advancing data science and AI research! The Johns Hopkins Data Science and AI Institute Postdoctoral Fellowship Program is now accepting applications for the 2026–2027 academic year. Apply now! Deadline: Jan 23, 2026. Details and apply: apply.interfolio.com/179059

🚀 New preprint! The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab! 🔗 www.biorxiv.org/content/10.6...

Hot from the presses! Laura Sena's @laurasenamd.bsky.social team at at Johns Hopkins working hard to expand the toolkit to treat patients with prostate cancer! Super excited to see out: doi.org/10.1158/0008... This study was made possible by the support of the PCF @pcf-science.bsky.social

Excited to dig into this!!!

Nature Cell Biology@natcellbio.nature.com · 9mo ago

☕Liu et al. present TemporalVAE, a method for integrating single-cell time course data. The model proposes a workflow to determine the biological timing of samples and its temporally sensitive genes, enabling single-cell developmental stage inference. 👉https://rdcu.be/eP9HH bit.ly/49VARB8