Sara R Heras
@herassr.bsky.social
Transposable elements in development and disease
Felices por haber organizado y compartido las Primeras Jornadas Andaluzas sobre el Síndrome 22q11.2. Gracias a todos los que lo hicieron posible! www.genyo.es/investigador...
Investigadores de la UGR y GENyO, clínicos y la Asociación Síndrome 22q11.2 Andalucía estrechan lazos para impulsar el abordaje integral del Síndrome 22q11.2 - GENyO
genyo.es
If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️ We are looking for a postdoc to join our team at @imbavienna.bsky.social More details 👇🏻
Institute of Molecular Biotechnology@imbavienna.bsky.social · 5mo agoWe are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below 👇
Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
Graphical abstract from our new paper in Nucleic Acids Research with @saramaciasrna.bsky.social 🧬 DGCR8 prevents accumulation of endogenous dsRNA derived from Alu elements within mRNAs, avoiding aberrant activation of the interferon response. academic.oup.com/nar/article/...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev
academic.oup.com
A great collaboration of my group with @herassr.bsky.social and @heick.bsky.social groups searching for mammalian dsRNAs and their importance to human disease 🧬
Ana Gázquez-Gutiérrez@anagazquezg.bsky.social · 5mo agoI'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NAR
I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NAR
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev
academic.oup.com
Our New paper in Nucleic Acids Research, in collaboration with @saramaciasrna.bdky.social! A new link between TEs, RNA regulation, innate immunity and 22qDS. Congrats to the authors,specially @anagazquezg.bsky.social academic.oup.com/nar/article/...
Validate User
academic.oup.com
Avanzamos en nuestras investigaciones sobre el síndrome #22q11. @herassr.bsky.social presentará los nuevos resultados publicados por nuestro grupo de investigación en la próxima conferencia internacional 22q11 que se celebrará en Creta en julio. Gracias a la asociación 22q Andalucía por su apoyo. 💪🏻
Mañana 22 de Noviembre es el Día Internacional del Síndrome 22q #22q11. En el grupo de @herassr.bsky.social en Genyo nos hemos sumado a su visibilización. #hazvisible22q
Deeply greatful to the 22q11.2 Andalucia Association and to all the artists and attendencees who filled the theater yesterday in Granada!! Your support helps us to move forward in understanding 22q11 Deletion Syndrome. #22q #22q11 #GENYO#UGR
TE x ZFP = Evolution! Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Olga Rosspopoff@orpsf.bsky.social · 9mo agoThrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social www.biorxiv.org/content/10.1...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
biorxiv.org
🚨 Our new preprint! In collaboration with @saramaciasrna.bsky.social and @heick.bsky.social labs 🧬 Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 and its implications in 22q11.2 deletion syndrome. #22q11 #TEsky #RNAsky
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
biorxiv.org
In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)? In collaboration with @herassr.bsky.social and @heick.bsky.social labs www.biorxiv.org/content/10.1...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
biorxiv.org
Exciting work! Plasmids are available at Addgene: www.addgene.org/browse/artic...
Addgene: Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase
addgene.org
Isaac Witte@isaacwitte.bsky.social · last yr.Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, a close collab between my PhD lab (Liu group) and @sternberglab.bsky.social, has been such a fun journey to help lead. Huge thanks to all contributors! www.science.org/doi/10.1126/...
The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
biorxiv.org
Epigenetics Update - OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide go.nature.com/4laK9MG #Epigenetics #DNAdemethylation #mESCs --- Gain deeper insights into gene regulation; epigenometech.com
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology
Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...
go.nature.com
We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓
💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...
pnas.org
Esta pérdida de un alelo de DGCR8 ocurre en el síndrome 22q11 y señala que no siempre los modelos de ratón reflejan la complejidad en humana. Gracias a los coautores y las IPs @herassr.bsky.social y @saramaciasrna.bsky.social, así como a @uji.es Artículo aquí ➡️ academic.oup.com/nar/article/...
🔴 NUEVO ARTÍCULO DE NUESTRO GRUPO en @narjournal.bsky.social!!! 🧬 #TEsky La pérdida de un alelo del gen DGCR8 en células madre embrionarias humanas afecta a su pluripotencia interfiriendo en una red de elementos transponibles y microARNs que es específica de primates. (1/2)
Our latest paper is out in NAR! 🥳 In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates. Read: academic.oup.com/nar/article-...
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects
Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2
academic.oup.com
Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC Thanks to all the coauthors and funders academic.oup.com/nar/article/...
No os perdáis este artículo sobre la relación entre los microARN y el cáncer. Por @herassr.bsky.social y nuestro socio Pablo Tristán
Guillermo Peris 🧬💻@waltzingpiglet.bsky.social · 2y agoSe ha publicado en @muyinteresante.com un artículo divulgativo escrito por @herassr.bsky.social y Pablo Tristán sobre el papel fundamental que juega el microARN let-7 como supresor de tumores evitando la movilización del transposón LINE-1. www.muyinteresante.com/fundacion/ca...