Miguel Paredes

@paredesmig.bsky.social

Working on Genomic Epidemiology & Phylodynamics. MD-PhD student at the University of Washington/Fred Hutch Cancer Center. He/him/él 🇨🇴🏳️‍🌈

Meningococcal B vaccine ddi not prevent Gonorrhea in this RCT. It is a negative result but an important one which emphasizes the need for N. gonorrhoeae specific vaccines. We are seeing higher rates on gonococcal infections and more drug resistance globally. www.nejm.org/doi/full/10....

Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM

No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...

nejm.org

The full results of the STOMP trial are now published in @nejm.org Tecovirimat did not shorten time to symptom resolution or impact symptoms of clade II mpox. The findings are similar to PALM007 trial which found no beneficial effects of the drug for clade I mpox www.nejm.org/doi/full/10....

Tecovirimat for the Treatment of Mpox | NEJM

Tecovirimat is approved for smallpox treatment under the Food and Drug Administration Animal Rule on the basis of efficacy in nonhuman primate models of mpox (previously known as monkeypox). Howeve...

nejm.org

Brilliant plenary on STI trends at #CROI2026. DoxyPEP implementation in Seattle shows indirect reductions of syphilis rates in cisgender women who are not the target group for the intervention. Shared sexual networks with men who are the target intervention group?

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I use this (overly simplified) schematic to explain to folks why maintaining high measles immunity is so hard. Even with 100% coverage, you get different outcomes depending on who and when you vaccinate. Consider a population with more kids than adults -- start with them all being susceptible.

graph with age on the x-axis and population size on the y-axis. A curve indicates population size decreasing with age. It is shaded in orange under the curve.

“What we found is there’s no significant excess risk with statins for almost all the conditions listed in statin packaging as potential side effects… We now have really good evidence that although these things may well happen to people while they take statins, that statins are not the cause”

Statins don’t cause most of the side effects on package warnings, study finds

Many people who should be taking statins avoid them for fear of side effects. A large new study says most of those side effects don't actually show up.

statnews.com

Oh boy. “The University of Florida and the Florida Department of Health in Alachua County are investigating potential measles exposure in two UF classes following two confirmed cases in the county. Health officials have begun contacting individuals who may have been exposed.” @aetiology.bsky.social

Measles exposure reported in two University of Florida classes, university says

The University of Florida and the Florida Department of Health in Alachua County are investigating potential measles exposure in two UF classes following two confirmed cases in the county.

news4jax.com