Carlos G. Ardanaz
@cgardanaz.bsky.social
Postdoc at @sophiesteculorum.bsky.social lab • @mpi-metabolism.bsky.social | Dazzled by sensory cues.
Supper happy to see this published. In short, we show how dendrites and inhibition allow neural circuits to learn new representations while protecting representations that are already stored in the network. See below for a detailed post by @cmiehl.bsky.social: www.sciencedirect.com/science/arti...
sciencedirect.com
🚨 New preprint from the lab: satiety impairs odour-guided food finding in mice. We show that insulin acts on PG cells in the olfactory bulb, inhibiting the Kv1.3 potassium channel, boosting their activity, and dampening olfactory nerve input 🧠🧪 doi.org/10.64898/202...
Insulin controls olfactory gain at the first central synapse by regulating periglomerular neuron excitability
Sensory processing is dynamically tuned by internal state, yet how metabolic signals reshape the earliest stages of sensory circuits remains poorly understood. Here we identify a circuit mechanism by which satiety suppresses olfactory sensitivity at the first central synapse in the mouse olfactory bulb. Using a within-animal paradigm modelling fasted and glucose-induced sated states, we show that satiety impairs food-finding behaviour and reduces olfactory receptor neuron input to the olfactory bulb. Periglomerular (PG) cells, which co-express insulin receptors and the potassium channel Kv1.3, mediate this effect: insulin inhibits the low-voltage-activated Kv1.3 current in PG cells, increasing their spontaneous and odour-evoked activity. This heightened PG cell activity drives enhanced presynaptic inhibition of olfactory receptor neuron terminals, dampening sensory input before it reaches mitral cells. These findings establish insulin-dependent presynaptic inhibition of PG cells as a key locus of state-dependent sensory gain control. ### Competing Interest Statement The authors have declared no competing interest. Medical Research Council, https://ror.org/03x94j517, MR/V003747/1 Biotechnology and Biological Sciences Research Council, BB/ Z51679X/1
doi.org
MORSE is out now in Neuron, with an expanded dataset: www.sciencedirect.com/science/arti... Using crosstalk to our advantage, we demixed norepinephrine & dopamine's binding at each other’s sensors to simultaneously quantify their release from locus coeruleus with resolution in the tens of nM.
@pnkalugin.bsky.social · 2y agoI’m thrilled to share our preprint presenting MORSE: a new way to simultaneously & quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope biorxiv.org/content/10.1101/2025.01.26.634931v1
Great to see our article out in this month's issue of @natrevgastrohep.nature.com, and pleasant surprise to have it chosen for the cover, and made available for free access! www.nature.com/articles/s41... www.nature.com/nrgastro/vol...
Nature Reviews Gastroenterology & Hepatology - Volume 23 Issue 8, August 2026
Gut–brain signalling, inspired by the Review starting on p608
nature.com
Are you at #FENS2026 in Barcelona? Don't hesitate to pass by my poster on Wed 8th to discuss hypothalamic food odor perception: PS03-08AM-595. And/or join my supervisor @sophiesteculorum.bsky.social on the Thu (9th) S39 symposium presenting on this!! Looking forward to discussing with you! 😊
Attending #FENS2026? So is the Steculorum Lab! 🤩 Come discuss our latest research with us! 🧠👃🍔 📌 Tue: PS02-07PM-013 @janice-bulk.bsky.social 📌 Wed: PS03-08AM-595 @cgardanaz.bsky.social 📌 Wed: PS03-08AM-596 by Joscha Schmehr 🎤 Thu: Symposium S39 (me 😊) See you in Barcelona! ☀️🇪🇸
What if the key to exercising better is what happens in the brain after the workout? Had so much fun writing this Preview with @sophiesteculorum.bsky.social: www.sciencedirect.com/science/arti... Congratulations to all authors, super elegant work @morgankindel.bsky.social @betleylab.bsky.social!!
Not just muscle: Exercise-induced brain rewiring as a driver of endurance and metabolic adaptation
Kindel, Post et al. establish that VMH SF1 neurons in mice encode exercise history and mediate endurance gains and exercise-driven metabolic benefits.…
sciencedirect.com
Sophie Steculorum@sophiesteculorum.bsky.social · 5mo ago✨Happy to share our preview with @cgardanaz.bsky.social on the latest exciting work from the Betley Lab🧠🏃♂️💪! Big congrats to @morgankindel.bsky.social , Ryan Post, @betleylab.bsky.social and all the authors for this amazing work 👏🎉 authors.elsevier.com/a/1n31A3BtfH...
✨Happy to share our preview with @cgardanaz.bsky.social on the latest exciting work from the Betley Lab🧠🏃♂️💪! Big congrats to @morgankindel.bsky.social , Ryan Post, @betleylab.bsky.social and all the authors for this amazing work 👏🎉 authors.elsevier.com/a/1n31A3BtfH...
You are what you eat! Actually, you are also what your mother smelled during pregnancy!🤰 👃smell of high fat diet during #pregnancy primes for #obesity in offspring Want to know more? Full story here www.nature.com/articles/s42... Congrats! 👏@sophiesteculorum.bsky.social @lcreimon.bsky.social
Fat sensory cues in early life program central response to food and obesity - Nature Metabolism
Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.
nature.com
🤩 I’m beyond excited to finally share our paper! 🎉 It’s been a long journey and a true team effort. Congratulations to our outstanding first authors, @lcreimon.bsky.social and Ayden Gouveia, and to all of the co-authors who made this possible 🙌! www.nature.com/articles/s42...
Fat sensory cues in early life program central response to food and obesity - Nature Metabolism
Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.
nature.com
Thanks @thetransmitter.bsky.social and to my lab for brightening my week with this rising stars in neuroscience award!! Wish I could be in #sfn to celebrate in the sun. Wonderful list of people: www.thetransmitter.org/early-career...
I'm more than psyched to share that my PhD paper is now out in Neuron! It's also my first paper as both first author and corresponding author, which means even more to me! Thank my partner Chi-Chieh for her contribution to the most adorable ever graphic abstract 🥰
Go ahead and apply to the @cga-age.bsky.social ⚡⚡ We are looking for a PhD student www.ageing-grad-school.de/phd/host-lab...
Cologne Graduate School of Ageing Research: Dr. Silvana Valtcheva
Join the Cologne Graduate School of Ageing Research to do your PhD or Master.
ageing-grad-school.de
Cologne Graduate School of Ageing Research@cga-age.bsky.social · last yr.Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny. 🗓️ Deadline: November 3, 2025. ℹ️ More info: www.ageing-grad-school.de 📣 Spread the news!
New paper live! Lots of us assumed that synaptic transmission decreases after energy shortage due to direct neuronal failure. But... Is that the case? Spoiler: no! It's astrocytes guiding them! ⭐ Check the full study with @maitesolas.bsky.social & others: www.aginganddisease.org/EN/10.14336/...
Astrocytic Glucose Sensing Drives Synaptic Depression under Metabolic Stress
<p>Glucose is the primary energy source for the brain, and its continuous supply is essential for neuronal function. Astrocytes play a pivotal role in brain energy metabolism by mediating glucose upta...
aginganddisease.org
@maitesolas.bsky.social · last yr.PAPER ALERT!📣📣 Low brain glucose? It’s not just neuron starvation. Astrocytes sense, respond, and regulate synapses. GLUT1 in astrocytes is a key player in protecting the brain from metabolic stress. Check out our full study with @cgardanaz.bsky.social www.aginganddisease.org/EN/10.14336/...
PAPER ALERT!📣📣 Low brain glucose? It’s not just neuron starvation. Astrocytes sense, respond, and regulate synapses. GLUT1 in astrocytes is a key player in protecting the brain from metabolic stress. Check out our full study with @cgardanaz.bsky.social www.aginganddisease.org/EN/10.14336/...
Astrocytic Glucose Sensing Drives Synaptic Depression under Metabolic Stress
<p>Glucose is the primary energy source for the brain, and its continuous supply is essential for neuronal function. Astrocytes play a pivotal role in brain energy metabolism by mediating glucose upta...
aginganddisease.org
This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...
A simple action reduces high-fat diet intake and obesity in mice
Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…
sciencedirect.com
Our new preprint: 𝐅𝐞𝐚𝐭𝐮𝐫𝐞-𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐭𝐡𝐫𝐞𝐚𝐭 𝐜𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐥𝐚𝐭𝐞𝐫𝐚𝐥 𝐬𝐞𝐩𝐭𝐮𝐦 𝐠𝐮𝐢𝐝𝐞𝐬 𝐝𝐞𝐟𝐞𝐧𝐬𝐢𝐯𝐞 𝐚𝐜𝐭𝐢𝐨𝐧. We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs. www.researchsquare.com/article/rs-6...
Feature-specific threat coding in lateral septum guides defensive action
The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral septum...
researchsquare.com
📢 🤩Excited to share our latest paper👃🧠! Huge thanks to the amazing first author @janice-bulk.bsky.social and all co-authors, especially @andreas-t-schaefer.bsky.social and @tobiasackels.bsky.social 🙌! www.nature.com/articles/s42...
A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
nature.com
My first first-author paper is live - this is amazing!! 🤩 Check it out in Nature Metabolism: www.nature.com/articles/s42... I can't thank my co-authors and everyone who helped make this happen enough! @sophiesteculorum.bsky.social @mpi-metabolism.bsky.social
A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
nature.com
Exciting news from @sophiesteculorum.bsky.social Lab!🤓 👃🧠 Smelling food primes your brain for satiety. Find out more in 🧵 or under 🔗 www.nature.com/articles/s42... Congrats to @sophiesteculorum.bsky.social , first author @janice-bulk.bsky.social and all contributing authors!
A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
nature.com
🚨 Paper alert! 📣 We found abnormal feeding-related neural responses in satiety-promoting, MC4R-expressing neurons in the mouse paraventricular hypothalamus (PVH-MC4R) following diet-induced obesity. www.biorxiv.org/cgi/content/... #obesity #feedingbehaviour #obesityresearch #neuroscience
Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons
Melanocortin-4 receptor-expressing neurons in the paraventricular nucleus of the hypothalamus (PVHMC4R) integrate hunger-promoting and hunger-suppressing signals to regulate satiety. Food consumption-...
biorxiv.org
Last week I had the pleasure to attend and present a poster at the GRC Modulation of Neural Circuits and Behavior. Unbeatable sharing of science, companionship... and breathtaking venue catalyzing all of it!
🚨 Preprint alert! 🚨 Can mice estimate the distance to an odour source? New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself. Spoiler alert: Yes, they can! Read the paper here: bit.ly/43A9tF9 Short 🧵 below
