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Paper Skygest Team@paper-feed.bsky.social · 12mo ago

**Please repost** If you're enjoying Paper Skygest -- our personalized feed of academic content on Bluesky -- we'd appreciate you reposting this! We’ve found that the most effective way for us to reach new users and communities is through users sharing it with their network

Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!

Rarely categorical, highly separable representations along the cortical hierarchy - Nature

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

nature.com

A hackathon reveals that disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data, write @mattiachini.bsky.social and Gaelle Chapuis. #neuroskyence www.thetransmitter.org/reproducibil...

18 teams analyzed a neuro dataset and got different answers

Disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data.

thetransmitter.org

Stopping Vought’s proposed rule will be critical to save science and future cures. @standupforscience.net created an action center to help you comment and contact Congress. Time to get loud! fight2win.standupforscience.net

Stand up for Science

Stand up for Science

fight2win.standupforscience.net

If you are going to comment on the proposed changes to how science is done in the US, please use this guide. The rules specify that you have to mention the number associated with the proposed changes, and this blog has those. Here is where to comment: www.federalregister.gov/documents/20...

Regulation for Federal Financial Assistance

The Office of Management and Budget (OMB) proposes to revise the Guidance for Federal Financial Assistance to improve government- wide policies and requirements related to the management of grants, co...

federalregister.gov

Susana Wadgymar🌿🔬@smwadgymar.bsky.social · 2mo ago

Here's a summary of what is being proposed: elizabethginexi.substack.com/p/summary-of...

Ways to push back against the proposed OMB regulations fight2win.standupforscience.net

🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu

Nature@nature.com · 3mo ago

Nature research paper: A critical initialization for biological neural networks go.nature.com/4tRNjIu

We are hiring a postdoc! We study neural activity and movement using holographic optogenetics, imaging, and recordings in awake mice. My first postdoc, Masashi, is starting his own lab, so now we have an opening. Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com

Oldenburg Lab

Decoding the motor system through the use of multiphoton holographic optogenetics.

oldenburglab.com

🚨🧪🧵URGENT INPUT NEEDED: NIH asks input for next strategic plan-including emphasis on non-animal models (NAMs) to replace animals. Per NIH insider, anti-animal responses now outnumber scientists 200-700x. Please please provide input. Deadline: May 26, 11:59 PM ET. grants.nih.gov/news-events/...

I need your help. When I'm making projects happen, I don't have as much time to remind people to buy merch/donate to Skype a Scientist. SO our balance sheet is...oh dear 😅 If you're able, becoming a monthly donor, even a couple bucks a month, would be really amazing. givebutter.com/SupportSAS26

Support Skype a Scientist!

By Skype a Scientist

givebutter.com

🚨 Ever wanted a simple way to control the activity of thousands of neurons? We introduce an all-optical raster photostimulation method to do just that! w/ @computingnature.bsky.social @marius10p.bsky.social #FluorescenceFriday #neuroskyence www.biorxiv.org/content/10.6... 1/n

Thrilled to share our work out in @nature.com today! Linking flexibility modeling, single-cell imaging, and targeted optogenetics allowed us to characterize how some prefrontal neurons, and mPFC-VTA neurons in particular, drive contingency degradation behavior. www.nature.com/articles/s41...

Prefrontal to ventral tegmental area dynamics drive contingency degradation - Nature

This work provides a mechanistic understanding of how certain prefrontal circuits in the rodent brain permit flexibility to selectively stop learned behaviours through interactions with core subcortic...

nature.com

I love this idea so much

Tim Behrens@behrenstimb.bsky.social · 3mo ago

What is the most interesting part of the brain? pmc.ncbi.nlm.nih.gov/articles/PMC...

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Eager to learn how one shanks a P10 rat with a neuropixels Very cool stuff

Matteo Guardamagna@matteoguardamagna.bsky.social · 5mo ago

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

1) Why is this the first I’m learning about fish talking to each other by slapping their bellies 2) The actual results in this paper are awesome

Benjamin Judkewitz@benjulab.bsky.social · 5mo ago

First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

how a small (~15) prolific and opinionated set of reviewers could steer a field over time This is great, and even these numbers underestimate the effect. Some fields have <10 qualified reviewers, one loud voice can tank or lift papers on its own

The Transmitter @thetransmitter.bsky.social · 5mo ago

Broad peer review is crucial for a healthy scientific literature, but neuroscientists turn down review requests too often. Simple math suggests that small groups of scientists can significantly bias the literature, writes @jvoigts.bsky.social. #neuroskyence www.thetransmitter.org/publishing/l...

Our perspectives piece on Agentic AI for biomedical research has been published in Nature Biotechnology www.nature.com/articles/s41... #agenticAI #artificialintelligence #agents

Agentic AI and the rise of in silico team science in biomedical research - Nature Biotechnology

This study examines the emerging use of agentic artificial intelligence (AI) in biomedical research, highlighting the challenges and opportunities that may inform the design of agentic AI systems suit...

nature.com

Science has now published our eLetter responding to Rajendran et al., titled, “Data show that macaques do not synchronize to a beat” doi.org/10.1126/scie...

Monkeys have rhythm

Synchronizing movements to music is a hallmark of human culture, but its evolutionary and neurobiological origins remain unknown. This ability requires (i) extracting a steady rhythmic pulse, or beat,...

doi.org

Pat Savage@patrickesavage.bsky.social · 6mo ago

We (@johnmcbride4lyf.bsky.social, @yutoozaki.bsky.social, @mhoeschele.bsky.social, Alex Ruf, Raphaël Powis, @musiccognition.bsky.social & I) wrote this up into a formal critique of the Science paper claiming to demonstrate beat synchronization in macaques: doi.org/10.31234/osf...

For all the energy we use in developing new technologies and fancier data handling, this is an immediate, actionable problem that we need to prioritize Beautifully written!

Nanthia Suthana@suthanalab.bsky.social · 6mo ago

The biggest problem holding neuroscience back right now isn’t data or tools, thanks in large part to the BRAIN Initiative. It’s fragmentation across species. I wrote this to hopefully spark discussion around an issue that can only be solved as a community👇 www.thetransmitter.org/animal-model...

New lab preprint! Can we study conscious perception of gut sensations in mice to reveal its neuronal basis? Can we train mice to report their gut sensations? Omer Rafael and Stav Shtiglitz in the lab teamed up to discover that…YES! Thread…1/6 www.biorxiv.org/content/10.6...

Almost feels wrong to see suite2p as a paper after all these years, used to it being a more of a silent pillar

Carsen Stringer@computingnature.bsky.social · 6mo ago

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

lab preprint! Interopceptive predictions are central to many brain-body interactions theories, but it's unclear if/how they affect bodily physiology. We (fearless Einav Litvak et al) show that insular cortex predictions are essential for glucose homeostasis-THREAD.. www.biorxiv.org/content/10.6...

Insular cortex predictions regulate glucose homeostasis

Brain-body interactions are essential for physical and emotional homeostasis. The brain uses information from the external world to predict upcoming bodily changes. This process involves interoceptive...

biorxiv.org

We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect. The full study is now online at Cell. @cp-cell.bsky.social Paper 👉 www.cell.com/cell/fulltex... Thread for a synopsis 👉 bsky.app/profile/alex...

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

cell.com

Alex Kwan@alexkwan.bsky.social · 12mo ago

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

In @thetransmitter.bsky.social’s Rising Stars of Neuroscience 2025, we recognize 25 early-career researchers who have made outstanding scientific contributions and demonstrated a commitment to mentoring and community-building in neuroscience. #neuroskyence #StateOfNeuroscience bit.ly/4rnFnyQ

Thanks @thetransmitter.bsky.social and to my lab for brightening my week with this rising stars in neuroscience award!! Wish I could be in #sfn to celebrate in the sun. Wonderful list of people: www.thetransmitter.org/early-career...

Woulda guessed 50%, glass half full kinda person

The Transmitter @thetransmitter.bsky.social · 9mo ago

Hundreds of animal studies about early brain injury after subarachnoid hemorrhage show signs of image manipulation or duplication, which may have stalled research into treatments. By @lauren-schneider.com #neuroskyence www.thetransmitter.org/publishing/i...

ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS Comment period ends September 29th www.federalregister.gov/documents/20... 1/2

Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media

Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...

federalregister.gov

graphical abstract goes hard

Mackenzie Weygandt Mathis@trackingactions.bsky.social · last yr.

Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes Cell 🎉 I was delighted to provide multi-ant pose and segmentation analysis for this incredible new work from the Berger lab @upenn.edu