Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs

So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology

Fresh out of the lab! Our new preprint is now up on BioRxiv, exploring how the beneficial bacterium Pseudomonas putida controls its T6SS nanoweapon. It turns out the Gac/Rsm pathway acts as a strict molecular brake on the system. 👇 (1/4) Read the full preprint here: doi.org/10.64898/202...

Today is wear yellow day for Cystic Fibrosis Trust #CFWeek. Future Imperial Medics doing a Clinical Research & Innovation research experience with Precision-CF Innovation hub in YELLOW! Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk @imperialnhli.bsky.social

Today is wear yellow day to raise awareness of and fundraise for #CFWeek. Precision-CF Innovation hub in yellow! Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk @imperialnhli.bsky.social

With no treatment available when Michael was diagnosed with SPG50, his dad Terry built a team, launched Elpida and helped create a gene therapy now improving Michael's life. A powerful reminder this #RareDiseaseDay of the support needed for rare conditions.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

🔍How do fungal-bacterial pathogen interactions worsen disease outcomes? Check out our latest Micro Briefing highlighting new research from The MRC Centre for Medical Mycology at University of Exeter and Mackerere University, Uganda. Read the full paper here🔗 https://10.1099/jmm.0.002128

"Precarity is the one constant of academic science. Themes of instability thread themselves through everything we do." A brief blog post from me about the @ukri.org funding pause and who the real victims will be. occamstypewriter.org/mindthegap/2... #AcademicSky

An innovative approach supercharges the innate immune system to provide a first line of defence against respiratory infections. go.nature.com/4qQncQx

‘Universal vaccine’ protects mice against multiple pathogens

An innovative approach supercharges the innate immune system to provide a first line of defence against respiratory infections.

go.nature.com

📢📢📢Lectureships at Bristol!📢📢📢 We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline. Great department, great colleagues, great building, great city Details here: www.bristol.ac.uk/jobs/find/de...

journals.plos.org/plosbiology/...

Biomedical and life science articles by female researchers spend longer under review

Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...

journals.plos.org

Dr. Libby Duignan, CPI Scientist will present her work entitled 'Optimizing Phage Production: Strategies for Scale-Up, Purification and Analysis' at the Viruses of Microbiome 2026 meeting in Newcastle today. @northumbriauni.bsky.social @ukcpi.bsky.social, @cysticfibrosis.org.uk

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com

PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com

findaphd.com

🔬 Postdoc position – Infection Biology & Cryo-ET (Zurich) 🇨🇭 We are looking for a motivated Postdoc to join our interdisciplinary team. 📩 Interested? Check out the job advert: www.imm.uzh.ch/dam/jcr:cb17... 👉 More info on the lab: www.weiss-laboratory.com Please share with interested colleagues!

We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

🧪 New research by @basler-lab.bsky.social reveals a surprising microbial trade-off: Pseudomonas aeruginosa activates a defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. @unibas.ch @snsf.ch @nccr-antiresist.bsky.social 👇

How bacteria resist hostile attacks

Some bacteria use a kind of molecular “speargun” to eliminate their rivals, injecting them with a lethal cocktail. Researchers led by Prof. Marek Basler at the Biozentrum have now discovered that cert...

biozentrum.unibas.ch

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

research.pasteur.fr

JB Editor's Choice: Panich, Wadhwa et al. describe a new type of motility in Salmonella they refer to as "swashing", which does not appear to require active propulsion. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking. A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli. dx.plos.org/10.1371/jour...

Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane

In E.coli, three of the four Type VII ABC transporter systems have been structurally characterized. This study solves cryo-EM structures of the fourth Type VII ABC system, YbbAP-TesA, and suggests tha...

dx.plos.org

Really pleased to share the first paper to come out of the lab. We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung. The phylogenies indicate that the clones moved from lung->gut www.nature.com/articles/s41...

High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications

Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...

nature.com

Happy to share our latest T6SS review: nature.com/articles/s41... Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!

The type VI secretion system and associated effector proteins - Nature Reviews Microbiology

In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...

nature.com

It was powerful to see the many stories of how antibiotics have changed people's lives as part of the Fleming Initiative's takeover of the Piccadilly Lights in London last night. #WAAW2025

This week is World Antimicrobial Resistance Awareness Week and this #ResearchWednesday we wanted to explain why preventing and tackling antimicrobial resistance is so important to people with #cysticfibrosis. ➡️ www.cysticfibrosis.org.uk/news/improvi...

This week is World #AntimicrobialResistance Awareness week To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since

World AMR Awareness Week call to action: Patient and public involvement and engagement to improve impact on antimicrobial resistance – the time to act is now

A step change is required in citizen awareness of the global AMR health crisis and, crucially, public involvement in tackling it. The global context presents new challenges but real-world examples show what is possible and an historic moment approaches, that we can leverage for positive action.

bit.ly

Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use. buff.ly/JST7ZR1

So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...

Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications

Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...

nature.com

Rare disease research needs a more integrated and collaborative approach. Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.

Great kick off meeting for the Precision CF Innovation Hub @imperialnhli.bsky.social @janedaviescf.bsky.social. Awesome talks and a real energy. Thanks to funders @lifearc.bsky.social and @cysticfibrosis.org.uk