Gonzalo Parra
@gonzaparra.bsky.social
Ramón y Cajal Junior Group Leader @BSC_CNS 🇦🇷🇪🇸🏳️🌈 ENFJ | Bioinformatics | 3DSIG Co-Chair | @fi_uner, @exactas_uba, @mpi_bpc, @embl, @dkfz alumnus | @iscb BoD | Opinions my own
🚨 Last days to submit your abstract! 🚨 Join us at the ELIXIR 3D-BioInfo & ISCB 3D-SIG Annual Conference 🇮🇹 in Rome (25–27 Nov 2026) and share your latest research with the structural bioinformatics community. ⏳ Submission deadline: August 31 🔗 iscb.org/3dbioinfo202...
🌐 Just published in Bioinformatics Advances: "Bioinformatics in Español: Expanding open, diverse, and collaborative science through SEH2Bioinfo" Find it here: https://doi.org/10.1093/bioadv/vbag182
Join us in Rome later this year! we have six topic sessions and we are eager to get your abstracts!!! 🙌 The submission deadline for 3DBioInfo has been extended to August 31! Submit your abstract!! 🔗 iscb.org/3dbioinfo202...
From @gonzaparra.bsky.social and colleagues in #OUP 's @bioinfoadv.bsky.social journal | Bioinformatics in Español: expanding open, diverse, and collaborative science through SEH2Bioinfo | #Bioinformatics #OpenScience #Education | 🧬🖥️🧪🔓 ⬇️ academic.oup.com/bioinformati...
Bioinformatics in Español: expanding open, diverse, and collaborative science through SEH2Bioinfo
Abstract. Linguistic inequality remains a silent barrier in contemporary science, particularly in rapidly evolving and interdisciplinary fields such as bio
academic.oup.com
1/ New preprint! with @solersanchisx.bsky.social @cwjpugh.bsky.social @federicobilleci.bsky.social @jonnyfrazer.bsky.social and Mafalda Dias, we introduce a scalable framework to improve stability prediction and separate folding from functional constraints. www.biorxiv.org/content/10.6...
Blending physics-based and inverse folding models to disentangle variant effects on stability and function
Protein sequences are constrained not only by the need to fold into stable structures, but also by specific functional requirements imposed by natural selection. Yet predictions of how amino-acid chan...
biorxiv.org
🚨 Paid MSc research opportunity at CRG Barcelona! With Mafalda Dias and @jonnyfrazer.bsky.social, we’re hosting a 4-month MSc project: 🧬 “Folding versus function: disentangling the molecular mechanisms of missense variants in gene-trait associations” More info 👇 www.crg.eu/en/content/t...
Happy to share our review "Local energetic frustration: Protein evolution, conformational dynamics and design in the age of AI" now in press in BBA – Proteins and Proteomics! 1st review article from my lab! authors.elsevier.com/a/1nafq5bCYA...
Blend to disentangle! New preprint led by our talented postdoc @eag91.bsky.social
Ezequiel Galpern@eag91.bsky.social · last mo.1/ New preprint! with @solersanchisx.bsky.social @cwjpugh.bsky.social @federicobilleci.bsky.social @jonnyfrazer.bsky.social and Mafalda Dias, we introduce a scalable framework to improve stability prediction and separate folding from functional constraints. www.biorxiv.org/content/10.6...
It’s time for the World Cup final with one of the greatest footballers that may be playing his last cup So time for a short thread on a link between Messi and an intrinsically disordered protein. 1/n
Could molecules from long-extinct species help fight #antibioticresistance? Researchers are exploring #MolecularDeextinction to uncover novel #antimicrobials, including #peptides from the #extinct moa. A PNAS Core Concept piece: https://ow.ly/hxAy50Z6fHF #evolution #genome
📢 #KRAS degradation induces rapid lung #cancer regression in preclinical mouse models: A study by #IRBBarcelona & @ciccancer.bsky.social demonstrates that eliminating mutated KRAS protein using #PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma. ➡️ https://bit.ly/4dFWhm1
Forgot spike-ins in your lrRNA-seq experiment? 😅 No problem! Our TUSCO benchmarks your transcript models using endogenous single-isoform genes as internal ground truth. Integrated in SQANTI3 for human & mouse. 🧬 Just out in @natcomms.nature.com @pacbio.bsky.social @nanoporetech.com rdcu.be/fkZCb
TUSCO: benchmarking transcriptome reconstruction with endogenous single-isoform controls
Nature Communications - Long-read sequencing enables comprehensive transcriptome characterization but remains challenging to benchmark due to sequencing errors, sample variability, and the limited...
rdcu.be
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
I am writing my first review as a last author without collaborating with any of my previous mentors. Scary... I feel like moving alone far from my parents for the first time 😅
Please, don't write cover letters with AI when applying to jobs. Selection committees see so many of them in a short time window and artificial constructions become too evident. I prefer an honest cover letter with grammar errors, made with effort, rather than a fake one.
On this 1st April I'm happy to release a technical report from our startup MirageBio, describing a new protein structure model with state-of-the-art performance. jgreener64.github.io/posts/techni...
MirageBio technical report
jgreener64.github.io
Paper accepted in my inbox. WooHoo! It never, ever, gets old. Another brick in our edifice of knowledge of life and the universe, and I helped craft this brick.
Atlas of predicted protein complex structures across kingdoms www.nature.com/articles/s41... www.biopredictnavigator.cn
Atlas of predicted protein complex structures across kingdoms - Nature Communications
Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,67...
nature.com
🔬 El #CSIC es el mayor organismo científico de España, con 124 institutos 👩🔬👨🔬 Sus equipos realizan investigación básica para ampliar las fronteras del conocimiento Repasa aquí las noticias destacadas de esta #SemanaCSIC 👇📹🧵
"genAI can be used to create podcasts from a paper to teach st-" Let me stop you right there. Before you feed somebody's paper to a slop machine, invite that somebody to talk to your students about their paper. We're right here. We academics won't shut up about our work, man. 🧪
🚨 New postdoc opening in my group at @bsc-cns.bsky.social! We’re looking for someone excited about protein evolution, local frustration, ML, & large-scale computational biophysics 🧬 Access to world-class HPC (MareNostrum) + great team! www.bsc.es/join-us/job-...
158_26_LS_ESB_R2
Reference: 158_26_LS_ESB_R2 Job title: Postdoctoral Researcher – Protein Computational Biophysics (R2) About BSC The Barcelona Supercomputing Center - Centro N
bsc.es
Are protein–ligand models moving beyond memorization? 🤔 & what does physically informed deep learning really mean for drug design? Find out more about the webinar & register in this link: 👇 elixir-europe.org/events/3d-bi... 🎤 Janani Durairaj 🎤 Markus Lill 📅 April 15 | 17:00 CET
🧩 Just out in Bioinformatics Advances: "Deciphering cis-regulatory elements using REgulamentary" Read the full paper here: https://doi.org/10.1093/bioadv/vbag079
📣 Reminder: #ISMB2026 is accepting abstracts for talk and poster presentations until Thursday, April 9, 2026. 📥 Submit here: https://www.iscb.org/ismb2026/call-for-submissions/abstracts
Today!!! Register and attend by using the links in the post below!
ELIXIR Europe@elixir-europe.org · 6mo ago✨ The next #ELIXIR_3DBioInfo webinar will focus on computational #biophysics. 🗓️ 10 March 2026 | 🕔 17:00-18:00 CET Join the webinar to hear the recent activities in the Community, including dark energy in functional #protein and fold-switching behaviour of RfaH. 👉 https://loom.ly/ctFNLug
✨ The next #ELIXIR_3DBioInfo webinar will focus on computational #biophysics. 🗓️ 10 March 2026 | 🕔 17:00-18:00 CET Join the webinar to hear the recent activities in the Community, including dark energy in functional #protein and fold-switching behaviour of RfaH. 👉 https://loom.ly/ctFNLug
