Grab a pint and listen to this. What a story youtu.be/29abxJgCyOI?...
Glen Hansard meets Van Morrison
YouTube video by bannedfromchina
youtu.be
Manuel Mendoza
@longchrom.bsky.social
Nuclear pore complexes and RNA export, Chromosomes and cytokinesis @igbmc.bsky.social Strasbourg. Who took the Bomp from the Bompalompalomp? Who took the Ram from the Ramalamading-dong? 🇻🇪 🇪🇸 🇫🇷
Kudos to @science.org for this self-analysis of the peer review process. These kind of data are never shared and don't have to be. Wildly refreshing to see it out in the open. Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/...
Editorial and peer review dynamics at elite general science journals
Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.
science.org
Send this to whoever is currently posting migrant invasion content to your timeline mrandrewfox.substack.com/p/ceutas-pha...
Ceuta’s phantom invasion
The online right declared the fall of Europe. By nightfall, most of the supposed invaders were already back in Morocco.
mrandrewfox.substack.com
Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - UOD2336
Closing date: Thursday 27 August 2026, 23:59
dundee.ac.uk
We're looking for a highly motivated Postdoctoral Fellow (Ref. PD/26/11) to join our team at @irbbarcelona.org to study MAPK signaling & conserved stress adaptation mechanisms, using cutting-edge transcriptomics, genomics & proteomics. Apply here: recruitment.irbbarcelona.org/jobs/8135937...
Postdoctoral Fellow (Ref. PD/26/11) - IRB Barcelona
Your Role & Our Team IRB Barcelona is seeking a highly motivated and talented Postdoctoral Fellow to participate in cutting edge research line -Crosstalk analysis of MAPK signaling- of the ...
recruitment.irbbarcelona.org
Excited to share this personal story published by @GeneticsGSA. A reflection on my journey in genetics, the many people who shaped it, the @haploteam and my enduring fascination with diversity. Thanks to everyone who has been part of the adventure! academic.oup.com/genetics/adv...
The genetics of the many forms of diversity
Abstract. The Genetics Society of America Medal honors an individual member of the Society for their contributions to the field of genetics at the midcaree
academic.oup.com
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...
Analog intrinsic recoding measures RNA dynamics without chemical conversion
Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...
biorxiv.org
New online: A protective ESCRT sleeve for ultrafine DNA bridges
A protective ESCRT sleeve for ultrafine DNA bridges
Nature Structural & Molecular Biology, Published online: 29 July 2026; doi:10.1038/s41594-026-01856-xDNA bridges, thin DNA connections that link daughter cells after division, threaten genome integrity and can trigger catastrophic chromosome rearrangements. A new study proposes that ESCRT-III proteins form protective assemblies around fragile ultrafine DNA bridges, revealing an unexpected role for these membrane-remodeling complexes in genome protection.
dlvr.it
In which we share News (and our Views) on breakthrough work from the labs of @juanmartin-serrano.bsky.social, Wes Sundquist and Adam Frost. A protective ESCRT sleeve for ultrafine DNA bridges! Fun writing with @barrallabeth.bsky.social. @natsmb.nature.com doi.org/10.1038/s415...
New preprint! How does a cell "know" how big to make its nucleus? This has puzzled biologists since the 1800’s. We show the answer is physics: colloid osmotic pressure. 🧵1/5
bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2w agoNuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope https://www.biorxiv.org/content/10.64898/2026.07.21.739918v1
Always a pleasure to have given multiple hours to help as a member of a thesis advisory committee and to casually find out that the thesis was defended and deposited, without even an email about it from the student or the mentors… The kind of things people can only do once as far as I'm concerned
Great, detailed story on a death in a tragic & flawed Chinese gene therapy trial www.science.org/content/arti... Excellent job by Brendan Borrell w/ @retractionwatch.com. Complex, nuanced & in some respects damning. (On line version looks a bit longer than in Science.) (COI-quotes me, in passing).
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
science.org
Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope https://www.biorxiv.org/content/10.64898/2026.07.21.739918v1
Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨
IGBMC: PhD position available in Raphaël Pantier's lab
igbmc.fr
IGBMC@igbmc.bsky.social · 2w agoPhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...
The ultimate tldr on the OpenAI "rogue model" hacking incident 😅 (h/t @linege1 on X) But it would be useful to know the prompts OpenAI gave to the model....
This whole story is crazy, but the definition of terrorism in the US is particularly absurd podcasts.apple.com/fr/podcast/t...
That quote links to articles on AlphaFold (and variants) and GNoME, neither of which are large language models. AlphaFold shares some concepts with LLMs (attention and transformers); GNoME not so much. (2/7)
ESCRTs are repurposed when missegregated DNA persist during nuclear envelope reformation, at this point ESCRT-III binds this DNA and mounts the NoCut response to protect the genome
Juan Martin Serrano@juanmartin-serrano.bsky.social · 3w agoVery proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...
This is a gorgeous paper: amazing cell biology and fantastic structural data of ESCRT-III sleeves wrapping ultra fine DNA bridges. Congrats to all involved!
Juan Martin Serrano@juanmartin-serrano.bsky.social · 3w agoVery proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...
This would seem to throw some cold water on the @cellpress.bsky.social paper claiming to have made "the first eukaryote functionally independent of the spliceosome"
Aaron and the Hoskins Lab at UW Madison@uwmadisonrna.bsky.social · 3w ago
Also check out the preprint by the Skotheim lab that reaches similar conclusions using and orthogonal system to alter non-coding DNA content. www.biorxiv.org/content/10.6...
Synthetic expansion of non-coding DNA reveals physiological constraints on genome size
Genome size varies widely across eukaryotes, largely because of differences in non-coding DNA, but the physiological consequences of this variation remain unclear. To directly test how non-coding DNA ...
biorxiv.org
We just preprinted Marianna’s PhD work in which we asked: How does non-coding DNA affect cell physiology? And why do some organisms have so little of it while other genomes are 99% non-coding?
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 4w agoNon-coding DNA dictates cell size and impairs fitness by sequestering RNA polymerase https://www.biorxiv.org/content/10.64898/2026.07.10.737727v1
VPS4 and CHMP7 release centromeres from the nuclear envelope for post-mitotic positioning in daughter nuclei https://www.biorxiv.org/content/10.64898/2026.07.13.738224v1
Estoy que no cago con lo de Farage vs Binface. Para quien no lo sepa, intento explicarlo, porque hay detalles que yo mismo no entiendo bien, pero se avecina ganador sin discusión a Persono del Año. A ver:
1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics
This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...
nature.com
Quant à l'objectif (louable) d'augmenter le taux de succès à l'ERC... une bonne façon de *ne pas* y parvenir est de piéger les jeunes chercheurs dans des collaborations forcées avec des collègues seniors, leur retirant temps, énergie et marge de manoeuvre pour développer leur vision autonome