I am proud to have done this work alongside @johansenvbi.bsky.social under the supervision of Pablo Ranea-Robles and @clemmensenc.bsky.social at @cbmr.science, University of Copenhagen. Curious to learn more? Read it here: doi.org/10.1113/JP28...

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. ...

doi.org

New review from the lab, together with collaborators at Helmholtz Munich and Eli Lilly, now out in Nature Reviews Drug Discovery. @cbmr.science @natureportfolio.nature.com @jonaspetersen.bsky.social @johansenvbi.bsky.social www.nature.com/articles/s41...

The evolving landscape of obesity pharmacotherapy - Nature Reviews Drug Discovery

Incretin-based therapies are transforming the treatment of obesity and related comorbidities. This Review outlines the current landscape of obesity drug development, focusing on glucagon-like peptide ...

nature.com

"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case." @clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇 theconversation.com/the-science-... #obesity #metabolism

The science of weight loss – and why your brain is wired to keep you fat

The evolutionary science of weight regain unpacked.

theconversation.com

@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’ Lead author: @johansenvbi.bsky.social Senior author: @clemmensenc.bsky.social Read it here: www.cell.com/cell/fulltex...

The brain is the master regulator of food intake and energy balance. A brilliant new @cellpress.bsky.social review, including the mechanism of GLP-1 drugs, by @clemmensenc.bsky.social and colleagues, open-access www.cell.com/cell/fulltex...

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS: www.sciencedirect.com/science/arti...

Interoceptive processing in the nucleus of the solitary tract

The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…

sciencedirect.com

High-intensity exercise → lactate signaling → neurogenesis? Yes (in some brain areas), but forced treadmill stress might be a potential confounding factor. We unpack this and propose some solutions in our latest JC article in The Journal of Physiology (@jphysiol.bsky.social): doi.org/10.1113/JP28...

More strain, more brain: the impact of exercise intensity on neurogenesis

Click on the article title to read more.

doi.org

𝐋𝐄𝐀𝐏2: 𝐀 𝐧𝐞𝐰 𝐡𝐨𝐫𝐦𝐨𝐧𝐞 𝐰𝐢𝐭𝐡 𝐛𝐢𝐠 𝐢𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦? Research published today in @cp-cellrepmed.bsky.social shows that #insulin and #glucagon play a crucial role in regulating levels of LEAP2 - a newly discovered hormone with promise for treating cardiometabolic disease. 1/

New preprint on a cross-species atlas of the dorsal vagal complex and neural mediators of cagrilintide’s effects on energy balance @metabolcenter.bsky.social >580,000 cells mapping to 89 rat, mice and rhesus macaque cell populations! www.biorxiv.org/content/10.1... #Neuroscience #Obesity 1/3

Anyone interested in working with me at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, on how AMGEN's new obesity drug MariTide works? I have a 3 year postdoc position available! Deadline March 31st! please share www.jobs.cam.ac.uk/job/50529/

On #WorldObesityDay, we have contributed a SnapShot to a special Issue on Obesity in @cp-cellmetabolism.bsky.social covering brain actions of the current and emerging weight loss drugs. @jonaspetersen.bsky.social @johansenvbi.bsky.social Free access link: authors.elsevier.com/a/1kiaA5WXUlaX…

I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism www.nature.com/articles/s41...

A comprehensive spatio-cellular map of the human hypothalamus - Nature

HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.

nature.com

www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort

Thalamic opioids from POMC satiety neurons switch on sugar appetite

High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

science.org

1/3 Kicking off my 🦋 journey with news that my lab has been awarded an ERC Consolidator Grant! Feeling incredibly proud and grateful. The project builds on our long-term focus: homeostatic control of body weight and pharmacological approaches for sustained weight loss. cbmr.ku.dk/news/2024/er...

ERC grant funds research to support weight loss maintenance

Associate Professor Christoffer Clemmensen from the University of Copenhagen has received an ERC Consolidator Grant for a project that aims to develop new therapeutic interventions that will help peop...

cbmr.ku.dk

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety

Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

rdcu.be