Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics

Nature Metabolism, Published online: 22 July 2026; doi:10.1038/s42255-026-01557-1This study demonstrates that lipids in ascites impair T cell activation through disrupting TCR dynamics, which has translational implications for adoptive T cell therapies.

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Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer

Nature Metabolism, Published online: 23 July 2026; doi:10.1038/s42255-026-01578-wMitochondrial oxidative metabolism is found to strongly affect the response of colorectal cancer (CRC) cells to the chemotherapeutic drug 5-fluorouracil (5FU). Targeting mitochondrial metabolism sensitizes CRC cells to 5FU.

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Scientists map dormant cancer cells' hideouts, opening new targets for treatment

Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and UCL Genetics Institute have created a detailed map of cells within breast tumours and identified distinct neigh...

lms.mrc.ac.uk

Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics

Nature Metabolism, Published online: 22 July 2026; doi:10.1038/s42255-026-01557-1This study demonstrates that lipids in ascites impair T cell activation through disrupting TCR dynamics, which has translational implications for adoptive T cell therapies.

dlvr.it

Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy - Nature

Diet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models and human-to-mouse fecal microbiota transplantation experiments.

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Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion - Nature Metabolism

Tissue-specific fibroblast lipid cues are shown to significantly influence the invasion rate of squamous cell carcinomas (SCCs), with oral and lung fibroblasts promoting aggressive cancer behaviour through distinct lipid metabolic pathways, while dermal fibroblasts, being lipid poor, limit cutaneous SCC invasion.

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Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease

Jiang et al. show that microbial phosphoketolase (PKT) enhances anti-TNF efficacy in inflammatory bowel disease by rewiring macrophage glucose metabolism. Through a lactate-driven H4K12 lactylation-SERT axis, PKT promotes 5-HIAA production to expand Tregs. A prospective clinical trial further demonstrates that PKT-producing Bifidobacterium improves therapeutic outcomes.

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Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer - Nature Metabolism

TRIP6 phosphorylation triggers a signalling cascade that promotes glycolysis in KRAS-mutant colorectal cancer cells. The resulting lactate accumulation drives extracellular lactylation of CD44 on CD8⁺ T cells, thereby compromising their anti-tumour activity.

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ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas - Nature Metabolism

In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreased ALDH1L2 expression is accompanied by formate overflow, which can be used to monitor PDAC progression.

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FXR’s double life in bile ducts

Nature Metabolism, Published online: 28 April 2026; doi:10.1038/s42255-026-01528-6Biliary epithelial cells have long been viewed as passive conduits for bile transport. A study in mice now reveals that FXR signalling in these cells maintains a protective barrier, with implications for liver fibrosis therapy.

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The versatile interplay between steatotic liver disease and liver cancer - Nature Reviews Cancer

Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcoholic liver disease (ALD) are drivers of liver cancer, promoting its development through chronic liver injury and inflammation. In this Review, Rahbari et al. highlight the distinct pathophysiological mechanisms of progression and therapeutic advancements for MASLD and ALD, emphasizing the need for more tailored approaches to manage these complex diseases and their cancer risks.

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Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer

Nonsmall-cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases. Epidermal growth factor receptor mutations (EGFRm) occur in 15 and 40% of NSCLC in Western and Asian populations, res...

pubs.acs.org

Single-cell and spatial profiling in cancer biology and clinical oncology - Nature Cancer

Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of th...

nature.com

Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, driven by aggressive biology, profound therapy resistance, and scarce treatment options. Beyond classical metabolic rewiring, recent discoveries reveal that lipid metabolism plays a central and previously underappreciated role in PDAC progression. Emerging evidence shows that fatty acids, cholesterol, lysophospholipids, sphingolipids, and oxidized lipid species actively shape oncogenic signaling, influence stromal and immune interactions, and contribute to metastasis and treatment evasion. In this review, we highlight these recent advances and discuss how lipid-driven circuits intersect with major oncogenic pathways, including KRAS effectors and phosphoinositide 3-kinase–AKT. By integrating mechanistic insights with therapeutic perspectives, we outline new opportunities to exploit lipid-based vulnerabilities in pancreatic cancer.

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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion - Nature

Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.

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“Hidden drug storehouses” could explain treatment resistance in cancer

One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others.

healthcare-in-europe.com

Hidden drug reservoirs in cancer cells could explain treatment resistance

Cancer drugs can accumulate in hidden “storage hubs” inside tumour cells, creating uneven drug exposure across tumours, according to new...

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Hidden drug reservoirs in cancer cells could explain treatment resistance

Cancer drugs can accumulate in hidden “storage hubs” inside tumour cells, creating uneven drug exposure across tumours, according to new research from the MRC Laboratory of Medical Sciences (LMS) and ...

lms.mrc.ac.uk

Taking advantage of metastatic cancer’s need for fats

Secondary breast cancer tumours reprogram lung cells to feed them energy-rich fats. Could this dependency be their downfall?

crick.ac.uk

Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration

Nature Metabolism, Published online: 11 March 2026; doi:10.1038/s42255-026-01480-5A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling.

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Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

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Lessons learned from viral hepatitis testing that inform law and policy responses to steatotic liver disease

Nature Reviews Gastroenterology & Hepatology, Published online: 30 January 2026; doi:10.1038/s41575-026-01174-zSteatotic liver disease (SLD), which might lead to cirrhosis and hepatocellular carcinoma, is on the rise worldwide. This Expert Recommendation draws on lessons learned to tackle viral hepatitis and proposes a framework for SLD screening and testing policies.

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Mapping the plasma metabolome to human health and disease in 274,241 adults - Nature Metabolism

Using data from the UK Biobank, the authors develop a comprehensive human metabolome–phenome atlas, including a browsable web tool, to uncover unique metabolite–trait and metabolite–disease associations with time, and discuss potential causal relationships.

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FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

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The source of dietary fat influences anti-tumour immunity in obese mice

Nature Metabolism, Published online: 25 July 2025; doi:10.1038/s42255-025-01330-wThis study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

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