My dream tool! Cannot wait to try it !🥹

FocalPlane @focalplane.bsky.social · 2w ago

🔬🔦Our latest Imaging spotlight highlights FOCUS-3D, a tool for segmenting cells from 3D fluorescence images from Qinghua Zhang, @mads100tist.bsky.social, @gqyu.bsky.social & team. They tell us what’s different about FOCUS-3D and what makes it so useful and usable for biologists.

Ania Chrzanowska and @bassemh.bsky.social discuss why it is informative to think about neuronal circuit function from a developmental perspective. www.sciencedirect.com/science/arti...

Building brains, shaping behaviors: How developmental approaches illuminate the analysis of circuits and behavior

Developmental processes define the parameters of neural circuits and restrict the range of possible behaviors. Here, we briefly highlight how the deve…

sciencedirect.com

www.biorxiv.org/content/10.1... Our latest: Julien Pigeon and colleagues discover a mechanism linking post-translational modification of transcription factors to remodeling the chromatin landscape to regulate human cortical neurogenesis

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

The striking expansion of the human neocortex is driven by the ability of radial glial cells (RGCs) to prolong neurogenesis without exhausting their progenitor pool, thereby producing more neurons, pa...

biorxiv.org

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

bioRxivpreprint@biorxivpreprint.bsky.social · 9mo ago

Evolutionary dynamics of temporal transcription factor series in the insect optic lobe https://www.biorxiv.org/content/10.64898/2026.01.08.698497v1

Today, I pay tribute to Dr. Jane Goudall — remarkable scientist, who was truly inspirational. Her groundbreaking work, commitment not only transformed our understanding of the natural world but also inspired generations, including myself, to pursue science with purpose and passion. janegoodall.org

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder. www.linkedin.com/posts/bassem...

Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders | Bassem Hassan

Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder.

linkedin.com

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

science.org

Registration is now open for 2026 GRC on Neural Development @neuraldevgrc.bsky.social Register early because places go fast!

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social labs www.nature.com/articles/s41...

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications

This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...

nature.com

Dear president@harvard.edu, dear gaudet@mcb.harvard.edu, to learn more about the importance of #Drosophila and crucial role of @flybase.bsky.social, and how it gave rise to at least 9 Nobel laureates in Physiology and Medicine, please see this link: droso4schools.wordpress.com/why-fly/

It is a Great Honour to receive the 'Les Grandes Avancées en Biologie' award 🏅 from the @academiesciences.bsky.social and to share our work during this fabulous day celebrating Science. Thank you! @hassanbraindevlab.bsky.social @institutducerveau.bsky.social @frm-officiel.bsky.social

European-based researchers can help support future #flybase curation by donating at this site: www.philanthropy.cam.ac.uk/give-to-camb...

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

philanthropy.cam.ac.uk

FlyBase needs our help.

Lucas Waltzer @lucaswaltzer.bsky.social · last yr.

#drosophila @flybase.bsky.social request emergency funding: "As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate! www.philanthropy.cam.ac.uk/give-to-camb...

New from the lab: @maheandria.bsky.social and colleagues in collaboration with the Hiesinger, Stoeckli and von Kleist labs dissect the sequential emergence of axonal targeting during development in today's issue of Nature Neuroscience: rdcu.be/ek010

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster

Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

rdcu.be

Hot off the press: The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience: rdcu.be/ek010

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster

Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

rdcu.be

Highly recommended !

@tomtom-auer.bsky.social · last yr.

We are #hiring! Interested in comparative neuroscience? Check details here (www.unifr.ch/bio/en/depar...). We look for a motivated #PhD student or #PostDoc to combine genetics, physiology, neural circuit tracing, and behaviour to study taste processing evolution in #Drosophila. Please repost.

Proud to share my main postdoc work! 🧠 I asked: How to build a #brain that lead to #individuality? We show that adult brain wiring isn't fully predictable from genes or environment alone— the #stochastic nature of #development is a key third factor. #NatureNeuroscience www.nature.com/articles/s41...

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster - Nature Neuroscience

The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in stereotyped neuronal circu...

nature.com

“Decoding the brain: from methods to meaning." A great workshop to brainstorm! 👇

The Hassan Brain Development Team@hassanbraindevlab.bsky.social · last yr.

Anna CHRZANOWSKA, PhD, postdoc in The Hassan Brain Development Team @hassanbraindevlab.bsky.social is organizing a trainee-led symposium @institutducerveau.bsky.social June 2-4 Spread the word! nenckiopenlab.org/decoding/

How to define a (neural) cell type? Happy to share this piece of thought we put together with ‪@bassemh.bsky.social.

Bassem Hassan@bassemh.bsky.social · last yr.

@maheandria.bsky.social and I challenge the notion of a static and deterministic definition of a (neural) cell type and argue for its replacement by a multi parametric probabilistic definition in this perspective sciencedirect.com/science/arti...

Hi Fly, Mouse, Rat, Zebrafish, Worm, and Yeast communities- Looking for the latest numbers on gene conservation between your favorite species and humans (like I was!)? Please see this excellent review (Table 2) by S Yamamoto, @okanca.bsky.social, M Wrangler, and H Bellen rdcu.be/efiXa

Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans

Nature Reviews Genetics - This Review explores the use of non-mammalian model organisms in the genetic diagnosis of rare diseases, focusing on the use of worms, flies and zebrafish. The strategies,...

rdcu.be

Do not miss any news from the Pint of Science Festival! Pour ne rien rater du festival Pint of Science 🗓️ 19-21.05 👉 @pintsWorld.bsky.social

Dr Elodie Chabrol@eloscicomm.bsky.social · 2y ago

Vous êtes les meilleurs, merci beaucoup 🫶✨️🫶✨️🫶✨️

Journée portes ouvertes : le saviez-vous ? Les mouches drosophiles sont des modèles de choix pour les scientifiques. En effet, leur cerveau fonctionne selon les mêmes principes physiologiques que le cerveau humain.

📣 Postdoc opportunity ! Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗 klinglerlab.org Please share with your network 🙏

Today, Paris Brain Institute is joining forces with the #StandUpForScience movement to defend science and the scientists who make it.

🎉 Our @dianapinheiro.bsky.social is featured in a Women in Science book! The book, part of @cienciaviva.bsky.social's initiative, celebrates Portuguese women scientists. The latest volume launches tomorrow, #InternationalWomensDay, in Lisbon. 📖 Read more: imp.ac.at/news/article... #IWD2025

“An assault on science and scientists anywhere is an assault on science and scientists everywhere.” That says it all.

Kit Yates@kityates.bsky.social · 2y ago

“US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.” Strong and welcome stance from @Nature www.nature.com/artic... 1/2

France, now is not the time to reduce our scientific attractiveness !

Journal of Cell Science@jcellsci.bsky.social · 2y ago

In her Essay, Renata Basto highlights the huge budget cuts facing the scientific community in France. In response to the cuts, a group of researchers has formed the ‘Pour une Recherche d'Avenir’ initiative to secure the future of French research. journals.biologists.com/jcs/article/...

At the NIH, posters of women and scientists of color have been taken down. Shared by @ivancalcantara.bsky.social on X. 2/x

Wonderful talk from Robin Hiesinger on how natural neuronal networks self-organise: The Neurobiology of Artificial Intelligence youtu.be/OWnsVWKJCEs?...

IEEE CIS Webinar: The Neurobiology of Artificial Intelligence

YouTube video by IEEE Computational Intelligence Society

youtu.be