🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇

Noncoding transcription controls the developmental dynamics of long-range gene regulation

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

science.org

1/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org

SAVE THE DATE for the 13th Canadian Developmental Biology Conference — March 7–10, 2027 — bringing together researchers, trainees, and innovators in developmental biology from across Canada and beyond.

Let's get this hashtag started! The 2026 Santa Cruz Developmental Biology Meeting is happen this August! We will share updates using #SCDB26. Can't wait! scdb2026.sites.ucsc.edu

Registration is OPEN for the 2026 Santa Cruz Meeting on Developmental Biology!!! Please spread the word! @mads100tist.bsky.social @socdevbio.bsky.social @bsdb.bsky.social @xenbase.bsky.social @isdb.bsky.social @devbiol.bsky.social @the-node.bsky.social scdb2026.sites.ucsc.edu

Switching fields or wanting to become an expert in #zebrafish research? The @mblscience.bsky.social 2026 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field! Application deadline: March 2 Please spread the word! www.mbl.edu/education/ad...

SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

Thrilled to share our latest work from my fantastic postdoc fellow Dr. Emilio Méndez-Olivos: Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish, now published in @plosbiology.org! 1/8 dx.plos.org/10.1371/jour...

Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish

During vertebrate development, fibroblast precursors migrate from the sclerotome to specific tissues, but the mechanisms that guide these precursors remain unclear. This study shows that Pdgfab/Pdgfra...

dx.plos.org

Excited to share our latest work led by my PhD student Linjun Xie on sclerotome development: Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish, now published on @dev-journal.bsky.social! #zebrafish #devbio 1/8 doi.org/10.1242/dev....

Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish

Summary: Loss- and gain-of-function manipulations reveal that dynamic regulation of BMP signaling is essential for the induction and diversification of the sclerotome lineage in zebrafish.

doi.org

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

Switching fields and/or wanting to become an expert in #zebrafish research? The @mblscience.bsky.social 2025 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field! (New & final) Application deadline: March 28 www.mbl.edu/education/ad...

The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open. event.fourwaves.com/12cdb/pages

Hello science friends, we are in the market for a new -80C freezer. Any recommendations? Many thanks!

New @dev-journal.bsky.social editorial We know we have high standards - but we're committed to making publishing with us constructive From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science journals.biologists.com/dev/article/...

Constructive Critics: Development's approach to peer review

We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...

journals.biologists.com

"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing. www.nature.com/articles/s41...

The lives of cells, recorded - Nature Reviews Genetics

Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...

nature.com