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International Society of Developmental Biology

@isdb.bsky.social

ISDB is a non-profit scientific association that promotes the study of developmental biology

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Aaron Milstein @neurosutras.bsky.social · 8h ago

The Dascal Lab has been studying my daughter's neurodevelopmental disorder. This epic work characterizes human and mouse epilepsy and performs comparative RNAseq to identify candidate pathways for intervention. Stay tuned for my lab's companion slice physiology study! www.biorxiv.org/content/10.6...

Cross-species analysis of GNB1 I80T encephalopathy: conserved developmental, epileptic and neuronal transcriptome signatures

GNB1 encephalopathy (GNB1E) is a rare neurodevelopmental disorder caused by mutations in GNB1 gene encoding the G protein subunit Gβ1. Mechanisms linking these variants to neurological dysfunction rem...

biorxiv.org

Keri Martinowich @martinowk.bsky.social · yesterday

One more from mouse 🧠 for #FluorescenceFriday because I AM IN LOVE with that green neuron up top. These are virally labeled projection neurons in prelimbic cortex headed to either the locus coeruleus or the ventral tegmental area. Brought to you by RA Daniel Olivares and the LIBD circuits team.

Fluorescence microscopy image of mouse brain tissue in the cortex with neurons labeled with viral tracers in red or green.

Jorge Miranda Barrientos @jorge-miranda.bsky.social · 11h ago

These mPFC neurons are telling me that GRS @grc-frontal-cortex.bsky.social starts today!!! On my way to the airport. Can't wait to listen the amazing projects people are working on. So honored to co chair the GRS with @albitc.bsky.social

Xenbase @xenbase.bsky.social · 5h ago

The deadline for talk consideration for the 2026 Midwest SDB meeting has been extended to August 14th. Please register and submit your abstracts! www.midwestsdbincincy.org #science #devbio #cellbio #xenopus #frogs #MWSDB26

Nature @nature.com · 5h ago

Nature research paper: Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours go.nature.com/3UiC3bT

Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours - Nature

Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.

go.nature.com

Anh Hoang Le, PhD 🏳️‍🌈@anhhle2702.bsky.social · yesterday

Hot take but any reporter that makes the actin network visible will make any cell look awesome under the microscope! These Xenopus 🐸 ectoderm cells are expressing an actin tension sensor, and you can see the retrograde flow very nicely. Actin is better than microtubules 😁 #FluorescenceFriday

Jonathan Fenn @jfennbio.bsky.social · 2d ago

I was honoured to make a small contribution to this paper published today in Cell, detailing the first T2T genome assembly of the zebra finch, a crucial model species for neurobiology: tinyurl.com/tguttata

The complete genome of a songbird

Bird genomes are the smallest among amniotes; however, they remain challenging to assemble due to their structural complexity. This study presents a f…

tinyurl.com

Nature Methods @natmethods.nature.com · yesterday

DABEST 2.0: Estimation graphics for multi-group comparisons. www.nature.com/articles/s41...

Getting over ANOVA: estimation graphics for multi-group comparisons - Nature Methods

Nature Methods - Getting over ANOVA: estimation graphics for multi-group comparisons

nature.com

Science Magazine @science.org · yesterday

An RNA editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to recent work in #ScienceSignaling involving fruit flies and data from mice and human samples. https://scim.ag/4g2RNr3

A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging

The RNA editing enzyme ADAR slows intestinal stem cell aging by reducing proliferative MAPK signaling.

scim.ag

Melanie D. White @melaniedwhite.bsky.social · 2d ago

Happy #FluorescenceFriday! ✨ A peek beneath the surface of a quail embryo reveals the neuroepithelium and beautifully segmented somites hiding below. 📷 Captured by PhD student @samarar.bsky.social. 🔬😍

EMBO @embo.org · 2d ago

Interested in a cross-scale understanding of #mechanobiology? Join the EMBO Workshop "Forces across scales" in Porto, Portugal, 27–30 April 2027. Deadline: 1 December 2026 https://meetings.embo.org/event/27-forces-scales #EMBOforces #EMBOevents 🧪

Zak Swartz @zakswartz.bsky.social · 2d ago

Shining stars! 🌟 🎉 Our latest preprint is out, led by postdoc Beverly Naigles and research assistant Brian McGonagle, two amazing members of the lab and @mblscience.bsky.social community. www.biorxiv.org/content/10.6...

Nature Cell Biology @natcellbio.nature.com · yesterday

☕Using a dynamic fluorescent reporter, Tang et al. demonstrate that cancer stem cells are hyper-responsive to microenvironmental cues, which they sense and adapt to through YAP/TAZ signaling, thereby playing an essential role in breast cancer lung metastasis. www.nature.com/articles/s41...

Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ - Nature Cell Biology

Using a dynamic fluorescent reporter, Tang et al. demonstrate that cancer stem cells are hyper-responsive to microenvironmental cues, which they sense and adapt to through YAP/TAZ signalling, thereby ...

nature.com

Alex de Mendoza @alexdemendoza.bsky.social · 2d ago

The #LondonEvoDevo goes to Cambridge! Kindly hosted by @emiliapsantos.bsky.social, mark on your calendars *October 2nd* at the Main Theatre in the Department of Zoology (Cambridge). Registration (£0.00): docs.google.com/forms/d/e/1F.... All welcome to present: #PI #PhD #PostDocs, submit abstracts!

LondonEvoDevo meeting - October 2026

This event will take place on Friday October 2nd, 2026, at the Department of Zoology (Main Lecture Theatre), University of Cambridge, Downing Street CB2 3EJ, 12:30 - 18:30. There will be no posters, ...

docs.google.com

Stefan Schoenfelder @stefanschoenfelder.bsky.social · yesterday

Very happy to see this story finally out in @natbiotech.nature.com: www.nature.com/articles/s41... Fantastic collaboration with @lancasterlab.bsky.social on how to identify and ‘fix’ differentiation-compromised human pluripotent stem cells. @babrahaminst.bsky.social @mrclmb.ac.uk 🧵 below

Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells - Nature Biotechnology

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

nature.com

Cells & Development @cellsdev.bsky.social · yesterday

The testis is a fast evolving organ, and so is spermatogenesis. Did you know that bonobos have larger testicles than gorillas? In fact, they have the largest 🍒 in all of apes. Why? Well, @kaessmannlab.bsky.social et al discuss the molecular evolution of spermatogenesis here: doi.org/10.1016/j.cd...

Fig. 1. Major cell types in spermatogenesis. A segment of the cross section of a seminiferous tubule in the testes. In their development from spermatogonial stem cells to testicular spermatozoa, the cells move from the basal lamina of the seminiferous tubule towards the lumen, surrounded and nourished by Sertoli cells. The diploid spermatogonia differentiate into primary spermatocytes that undergo the first meiotic division, then called secondary spermatocytes, followed by the second meiotic division to form spermatids. These haploid cells differentiate from round spermatids to elongated spermatids and finally into immature spermatocytes, which detach from the Sertoli cells and travel to the epididymis, where they fully mature.

Fig. 2. Testicular chromatin remodeling. Throughout spermatogenesis (black arrow) histones are exchanged by testis specific histone variants. In the postmeiotic spermatids histones are exchanged by transition proteins (TNPs), the TNPs in turn are exchanged by protamines. The protamines facilitate the dense packaging of chromatin in the sperm head. During meiosis the unsynapsed sex chromosomes become sequestered in the sex body and transcriptionally silenced. One hallmark feature of the sex chromosomes in the sex body is the presence of phosphorylated H2AX along the entire chromosome length. Data from Kimmins and Sassone-Corsi (2005), and Turner (2015).

Fig. 3. Evolution of gene expression. Phylogenetic analyses of the translatome (thin and dark) and transcriptome (thick and light) for testis, liver, and brain (from top to bottom) reveal the rapid evolution of the testis. The branch lengths indicate evolutionary changes in expression levels. Data from Wang et al. (2020).

Fig. 4. Different rates of evolution in testicular cell types. Pairwise Spearman's rank correlation coefficient between human and other species for testicular cell types. The haploid cell types diverge faster than the diploid cell types. Adapted from Murat et al., Nature 2022, https://doi.org/10.1038/s41586-022-05547-7 | CC BY 4.0.

epithelial mechanics fan club @epimechfc.bsky.social · 2d ago

Maupérin, M., Sun, Y., Glandorf, T., Oswald, T. A., ... Yan, J., & Citi, S. (2025). A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics. Nature Communications, 16(1), 2514. www.nature.com/articles/s41... #EpithelialMechanics

Rafael D. Acemel @rdacemel.bsky.social · 2d ago

The Acemel lab is #hiring!! :) We are looking for a PhD student to join us at @cabd-upo-csic.bsky.social to study developmental plasticity, epigenetics and evolution using medaka 🐟 and AI models 💻 . Deadline for applications 4th of September. See more details 👇

Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · 2d ago

#JobOffer #PhDOpportunity @sebioldev.bsky.social @segenetica.bsky.social @isdb.bsky.social @csicandalucia.bsky.social @pablodeolavide.upo.es @sfbd.bsky.social

Rafael D. Acemel@rdacemel.bsky.social · 2d ago

Royal Society Publishing @royalsocietypublishing.org · last wk.

To eat or not to eat: that is the question! A new #OpenBiology review synthesizes current understanding of the neural and physiological mechanisms that shape feeding-related decision-making across species: doi.org/10.1098/rsob... #SystemsBiology

Eric Hall @erichall.bsky.social · last wk.

For #FluorescenceFriday we have, "TNTs, cytonemes, and migrasomes, oh my!"

Cells & Development @cellsdev.bsky.social · last wk.

It is often said that cancer is like development gone wrong. One of the most important signalling pathways of development, the Wnt pathway, is frequently altered in colon cancer. Nydia Tejeda-Muñoz et al discussed the complex biology of Wnt signalling network. Check it out: doi.org/10.1016/j.cd...

Fig. 1. Central role of the Wnt pathway in tumor initiation and progression, and its crosstalk with major oncogenic pathways. Aberrant activation of the canonical Wnt/β-catenin signaling drives tumorigenesis by sustaining proliferative signaling, enforcing stem-cell–like programs, and promoting survival under oncogenic and therapeutic stress. The Wnt pathway output is further amplified through extensive crosstalk with key oncogenic modules, including PI3K/AKT/mTOR, RAS/RAF/MEK/ERK (MAPK), and TGF-β/Sma and Mad Related Proteins (SMAD), which integrate upstream mitogenic cues, metabolic states, and microenvironmental signals. These interconnected networks generate feedforward and compensatory feedback loops that enhance cellular plasticity, support epithelial–mesenchymal transition, and drive therapy resistance, intratumoral heterogeneity, and metastatic competence.

Fig. 2. RAS–RAF–MAPK and its interaction with β-catenin and PI3K–AKT–mTOR in colon cancer. Aberrant RAS–RAF–MEK–ERK activity modulates the canonical Wnt signaling through multiple mechanisms, including phosphorylation-dependent regulation of β-catenin stability, transcriptional enhancement of Wnt target genes, and MAPK-driven remodeling of the tumor microenvironment. Conversely, hyperactivation of Wnt/β-catenin can potentialize MAPK signaling by upregulating growth factor receptors, stabilizing RAS, and reinforcing downstream proliferative circuits. This reciprocal reinforcement establishes feedforward loops that promote tumor cell proliferation, stemness maintenance, EMT, and metastatic dissemination. In addition, MAPK inhibition frequently triggers compensatory reactivation of the Wnt signaling, underscoring their functional interdependence and highlighting the therapeutic relevance of dual-pathway targeting in RAS- or BRAF-mutated malignancies. Direct regulation is indicated in solid lines, indirect effects are indicated in dashed lines.

Fig. 3. Mechanistic integration of the Wnt/β-catenin pathway with the PI3K–AKT–mTOR pathway in cancer. The canonical Wnt activation modulates the PI3K–AKT–mTOR signaling through multiple nodes, including inhibition of GSK3β, stabilization of downstream effectors, and transcriptional induction of receptors and metabolic regulators that enhance PI3K pathway output. Reciprocally, PI3K–AKT signaling reinforces the Wnt/β-catenin activity by inhibiting GSK3β-mediated β-catenin degradation, promoting nuclear β-catenin accumulation, and facilitating the transcription of Wnt-dependent oncogenic programs. mTORC1 further integrates inputs from both pathways to regulate translational capacity, metabolic rewiring, and cancer stem cell maintenance. This bidirectional crosstalk creates feedforward loops that drive tumor growth, survival under stress, therapy resistance, and metabolic plasticity, underscoring the relevance of dual-pathway targeting in PI3K- and Wnt-driven malignancies. Direct regulation is indicated in solid lines, indirect effects are indicated in dashed lines.

Fig. 4. Role of the Wnt pathway in dorsal–ventral axis specification and maternal determinant relocation. The maternal Wnt/β-catenin signaling directs early dorsal–ventral axis formation in Xenopus early embryos. Cortical rotation after fertilization translocates maternal dorsal determinants, including Dishevelled (Dvl) and Wnt pathway activators, from the vegetal pole toward the future dorsal side (A). This asymmetric distribution inhibits GSK3β locally, stabilizes β-catenin, and activates dorsal-specific genes such as siamois and twin, establishing the dorsal organizer and early polarity (C). Without Wnt signaling, β-catenin is degraded, maintaining low cytoplasmic levels (B). Perturbations of this pathway produce distinct phenotypes: Wnt inhibition leads to ventralized embryos lacking dorsal structures, while Wnt hyperactivation causes dorsalization, expanded organizer activity, and axis duplication. Ectopic Wnt activation in ventral blastomeres can induce a secondary organizer, occasionally resulting in embryos with two heads.

Cell - a Cell Press journal @cp-cell.bsky.social · last wk.

Now online! Basement membrane turnover controls cell shape

Basement membrane turnover controls cell shape

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane adapts by measuring collagen turnover. We find that perlecan, another basement membrane protein, regulates collagen turnover to control organ shape.

dlvr.it

Crystal Rogers, PhD @rogerslabucd.bsky.social · last wk.

Congratulations to @mayorlab.bsky.social on this well-deserved award! He gave a wonderful talk and I spotted some Vegas themes represented in his talk too! Placodes and fireballs!🤩

A pic of the society for developmental biology meeting, a screenshot of a talk showing placodes, and screenshot of a slot machine

Roberto Mayor Lab@mayorlab.bsky.social · 2w ago

Thank you to the Society for Developmental Biology @socdevbio.bsky.social it was a tremendous honour to receive the Viktor Hamburger Outstanding Education Award. Special thanks to @rrbehringer.bsky.social and all the organisers of the SDB meeting in Las Vegas for such a truly remarkable meeting.

epithelial mechanics fan club @epimechfc.bsky.social · last wk.

Cheng, B., Li, M., Lin, M., Guo, H., & Xu, F. (2025). Mechanobiology across timescales. Nature Reviews Physics, 7(11), 621–644. www.nature.com/articles/s42... #EpithelialMechanicsReview

International Society of Developmental Biology @isdb.bsky.social · last wk.

Consider submitting your articles to our special issues 🧡

Cells & Development@cellsdev.bsky.social · last wk.

If you're Chilean or work in Chile, or if your interest is w/ immunology and #devbio, submit to our special issues: 1. Chilean Developmental Biology: at Home and Around the World 2. Tissue Biology – at the interface between immunology and developmental biology www.sciencedirect.com/journal/cell...

Cells & Development @cellsdev.bsky.social · last wk.

Cells & Development | Article collections | ScienceDirect.com by Elsevier

Read the latest chapters of Cells & Development at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

sciencedirect.com

Yasin Dagdas @plantophagy.bsky.social · last wk.

Today's @cosheidelberg.bsky.social seminar speaker is @chc-evobio.bsky.social talking on chromatin evolution #evochromo. Check out his really cool #preprint here: www.biorxiv.org/content/10.6...

Developmental Biology @devbiol.bsky.social · last wk.

#DBfeature #LatestResearch The vascular–osteogenic interface in craniofacial development: a structured review of emerging associations in congenital malformations By Karl Jacobs et al. doi.org/10.1016/j.ydbio.2026.06.012

Formation of the craniofacial skeletal structures in the developing head. Regions are distinguished based on neural crest or mesodermal origin, as well as the embryological mechanism of bone formation (Reprinted from Journal of Cranio-Maxillofacial Surgery, Vol 45, Kruijt Spanjer et al., ©2017, with permission from Elsevier Kruijt Spanjer et al., 2017).

Zimeng Wu @zimengwu33.bsky.social · last wk.

Got to try out another microscope woo! 8 positions stitched taken on the new @Bruker lightsheet this morning