An aptly titled paper shows, for the first time, the significance of heterogeneities of gene expression in the construction of complex systems : fate decisions are group decisions. Previously @biorxivpreprint cell.com/cell/fulltex... #MustRead #Gastruloids @Jshendure lab

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348

Enhancer binding kinetics explain transcription factor hub formation

Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...

tinyurl.com

Happy #FluorescenceFriday. This video shows a group of neural crest cells (🟣) remodelling a mesh of fibronectin matrix (🔵). This is part of a biorxiv paper showing the reciprocal relationship between NC and neural tube morphogenesis. 📹: Kai Weißenbruch, UCL 👇👇👇 www.biorxiv.org/content/10.6...

#Macrophages are mechanosensitive cells. They respond to mechanical signalling from the surrounding tissue, such as during fibrosis. In this review, the authors discuss the significance of the macrophage-fibroblast communication in a profibrotic niche. #immune 👇 www.sciencedirect.com/science/arti...

Happy #FluorescenceFriday. This video shows a group of neural crest cells (🟣) remodelling a mesh of fibronectin matrix (🔵). This is part of a biorxiv paper showing the reciprocal relationship between NC and neural tube morphogenesis. 📹: Kai Weißenbruch, UCL 👇👇👇 www.biorxiv.org/content/10.6...

How do long-lived multipotent stem cells cope with mechanical stress in vivo? We found that neural crest cells are protected from mechanical stress during migration in confined tissue environment. www.nature.com/articles/s41...

In vivo DNA damage protection during cell migration across confining embryonic tissue environments - Nature Cell Biology

Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

nature.com

#optogenetics is getting attention!! Welcome aboard the Opto-train 🚄🚂

Cells & Development@cellsdev.bsky.social · 5d ago

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

#optogenetics is getting attention!! Welcome aboard the Opto-train 🚄🚂

Cells & Development@cellsdev.bsky.social · 5d ago

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

Woah, such an invaluable resource! You can use this for your lectures too and can make a good resource for students! 🙌

Physical Biology of Developing Systems@pbodslab.bsky.social · 6d ago

An interdisciplinary #embryology book is out as #OER: @ecampusontario.bsky.social ecampusontario.pressbooks.pub/principlesof... A teamwork turned raw lecture recordings into a colloquial writeup. Please pass any feedback & critiques! @isdb.bsky.social @swedbo.bsky.social @socdevbio.bsky.social 🧪🔬

An interdisciplinary #embryology book is out as #OER: @ecampusontario.bsky.social ecampusontario.pressbooks.pub/principlesof... A teamwork turned raw lecture recordings into a colloquial writeup. Please pass any feedback & critiques! @isdb.bsky.social @swedbo.bsky.social @socdevbio.bsky.social 🧪🔬

Principles of Development - An inquisitive journey into embryology -

This textbook covers key concepts of embryology and principles of development in an understandable but detailed enough pace for advanced undergraduate students. Intended audience is advanced (3rd/4th ...

ecampusontario.pressbooks.pub

Are #cilia still hot or ... 👀? Maybe it's time to learn how they are formed! This review by the Pereira lab discusses the structural composition of the distal appendages, how they form the cilia, and how they are regulated in cell cycle and in diseases! www.sciencedirect.com/science/arti...

Great new study from @knoblich-lab.bsky.social, led by @saku-wong.bsky.social, showing that human cerebral organoids cultured for over six months can recapitulate postnatal interneuron migration 🧪🧬🧫🧠 www.biorxiv.org/content/10.6...

Cerebral organoids recapitulate interneuron chain migration in the human cortex

The human brain is incomplete at birth, with streams of late-born interneurons migrating into the postnatal cortex. This process is absent in rodents, limiting mechanistic investigation to post-mortem...

biorxiv.org

CLOK: Truly beautiful new #zebrafish tool for birthdating neurons from the Koyama and Del Bene labs doi.org/10.1038/s415...

CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration - Nature Neuroscience

Faini et al. develop CLOK, a method that labels neurons across a spectrum of colors according to when they were born, allowing successive generations of brain cells to be tracked as they take shape in...

doi.org

Epigenetics News - Old hearts age backwards: transplanted organs adjust to host's biological age www.nature.com/articles/d41... #Epigenetics #News #Aging #Transplant --- Cancer, immunology, and aging; epigenometech.com

Old hearts age backwards: transplanted organs adjust to host’s biological age

Tracking the biological age of grafted organs suggests that donor pools could be expanded to boost organ availability.

nature.com

Why does the same virus kill one host and spare another? The key is lung imprinting from a previous parasitic infection. Our new study @nature.com offers answers + critical mechanisms! Immense thanks to @KamalmKhanna and our collaborators. 🧵 #Diseasetolerance #NAMs www.nature.com/articles/s41...:

Type 2 immune history trains lung macrophages for viral disease tolerance - Nature

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

nature.com

☕Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human #meninges and perform comparative studies with #meningioma data. www.nature.com/articles/s41...

Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas - Nature Cell Biology

Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human meninges and perform comparative studies with meningioma data.

nature.com

#DBfeature #LatestResearch 🐠👁️ Regenerated fish retinas are similar to undamaged retinas, but display local patterning errors in comparison with undamaged retinas; new models could test their functionality recovery. By Deborah L. Stenkamp doi.org/10.1016/j.ydbio.2026.07.009

Our latest study about how stratified myosin motors at the plasma membrane drive distinct nanoscale clusters that organize into segregated mesoscale active emulsions is out in Science Advances! Read on to find out more| Science Advances www.science.org/doi/10.1126/...

🧬 New research in Nature Cell Biology reveals how tissue flow helps guide immune cell migration and polarity. Congrats to Hoang Anh Le, Jonas Hartmann, Ricard Alert and collaborators! 👏🔬 #CellBiology #Immunology 🔗 www.nature.com/articles/s41...

If you're looking for a fun weekend read, I recommend @katiepickup.bsky.social's interview with the brilliant @nmoris.bsky.social in @dev-journal.bsky.social doi.org/10.1242/dev....

Transitions in development – an interview with Naomi Moris

Naomi Moris is a group leader at the Francis Crick Institute in London, UK. Naomi's lab uses in vitro embryo models derived from stem cells to study the early stages of human development and understan...

doi.org

Thank you Erdinc Sezgin @sciezgin.bsky.social for sharing your experience of fee-free #OA publishing @jcellsci.bsky.social via our #ReadAndPublish agreement with Karolinska Institute, Sweden @ki.se Read Erdinc’s paper: doi.org/10.1242/jcs.... Is your institution participating too? bit.ly/3O7BxGi

Out now in @science.org with a related Perspective Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion | Science www.science.org/doi/10.1126/...

Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion

Although tumor protein p53 (TP53) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we...

science.org

How about stress-induced ribosome hibernation in archaea? @diorgeps.bsky.social, @archaeon-alex.bsky.social, Joey Davis et al identify conserved archaeal factor AHA with evolutionary link to bacterial hibernation-promoting factor HPF & eukaryotic energy sensor AMPKγ link.springer.com/article/10.1...

A conserved archaeal protein with evolutionary links to bacterial ribosome hibernation and eukaryotic energy sensing - The EMBO Journal

Ribosome hibernation helps cells survive stress by reversibly silencing translation and preserving ribosomal complexes. Although well characterized in bacteria and eukaryotes, archaeal hibernation rem...

link.springer.com

So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...

Choi, B. J., Chen, Y.-C., & Desplan, C. (2025). Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye. Science, 390(6775), eady5541. #EpithelialMechanics www.science.org/doi/10.1126/...

#DBfeature #ICYMI Ascidian Botryllus humilis is capable of whole-body regeneration, becoming a promising new model for aging and stem cell dynamics. By Arzu Karahan doi.org/10.1016/j.ydbio.2025.10.002

An exciting milestone for the Bayin lab! Our first PhD thesis submitted! Congratulations @jensbager.bsky.social 🍾🍾 #proudPI 😍 Part of Jens’ PhD work can be found in our latest publication. journals.biologists.com/dev/article/...

Thinking hard if I can have something ready. This looks fantastic.

The Ramsey Lab@theramseylab.bsky.social · 2w ago

Are you interested in the past, present & future of Artificial Life (ALife) as a scientific field? 🚨 We are hosting an interdisciplinary minisymposium this December, so send us your work & come along! Please share widely! 🔗 hiw.kuleuven.be/clps/events/... #philsci #academicsky #evobio #AI #HPS

🦋 Butterfly wing patterns create motion illusions that protect them from predators! Our new study (8 years in the making) is out in Nature today doi.org/10.1038/s415... @grahancock.bsky.social @esbriolat.bsky.social @scienceanna.bsky.social @lauraakelley.bsky.social @uniexecec.bsky.social