A new study from the @squeezycellslab.bsky.social lab shows that the same cell population can experience completely different physical challenges within an embryo. Unlike the cranial counterpart, the trunk NCCs adapt as their nuclei are deformed during migration 👏 #ECR www.nature.com/articles/s41...

Laith Bahlouli, Marc Edwards and colleagues identify atypical PI3Ks as specialised regulators of signal attenuation, cAMP relay organization and membrane uptake in Dictyostelium. journals.biologists.com/jcs/article/...

Epithelial wound healing has mainly been analyzed at the apical plane of the epithelium – @yanlanmao.bsky.social and colleagues now reveal a contractile system that connects the apical and basal cell surfaces at the wound edge for efficient wound closure link.springer.com/article/10.1...

Three-dimensional mechanical cooperativity optimises epithelial wound healing - The EMBO Journal

Epithelial tissues serve as critical physical barriers that protect organs, making their efficient repair essential upon damage. To achieve this, tissues must quickly react, forcing cells to rearrange...

link.springer.com

🧬 New Research Spotlight 📢 Congratulations to @davidversluis.bsky.social on the latest publication in PLOS Computational Biology! 📖 Read the paper here: journals.plos.org/ploscompbiol... @ucllifesciences.bsky.social

Communication through autoattractants can enhance and limit collective migration of immune cells

Author summary Immune cells must travel through the body to reach sites of injury, infection, and developing tissue. They are guided by chemical signals. Many immune cells, such as neutrophils gatheri...

journals.plos.org

For #amphibians impacted by a widespread fungal pathogen, temperature is an important link between the host and the fungus. Zoo breeding programs provide opportunities to alter environments prior to release. This #RSOS paper investigated this on endangered #frogs: doi.org/10.1098/rsos...

Congratulations to Peter Hegemann winner of the Nobel Prize in Physiology or Medicine 2026 for discoveries concerning light-gated ion channels and optogenetics. Take a look at his 1992 #PhilTransB article on the photoreceptor current of the green alga Chlamydomonas: doi.org/10.1098/rstb...

Nobel Prize@nobelprize.org · 2w ago

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Our latest paper is now out in @dev-journal.bsky.social. We investigated how Notch signalling, implicated in Hirschsprung disease (HSCR) regulates human enteric nervous system (ENS) development (1/n): journals.biologists.com/dev/article/...

Notch signalling governs human enteric nervous system progenitor dynamics

The enteric nervous system (ENS) is the main branch of the peripheral nervous system that innervates the gastrointestinal tract controlling vital functions. It arises during embryogenesis via migratio...

journals.biologists.com

New commentary from the lab - can we identify principles of transcriptional regulation & cis-regulatory element (CRE) control of gene expression? With @jcornwallscoones.bsky.social & @joadelas.bsky.social in @cp-molcell.bsky.social A thread 🧵 doi.org/10.1016/j.mo...

🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

A new study from the @squeezycellslab.bsky.social lab shows that the same cell population can experience completely different physical challenges within an embryo. Unlike the cranial counterpart, the trunk NCCs adapt as their nuclei are deformed during migration 👏 #ECR www.nature.com/articles/s41...

An interesting and important study from the Montecino lab analysing the transcriptional differences between Schizophrenic iPSC neurons versus healthy control showing neuronal enrichment in SZ-cultures and astrocyte enrichment in CT. Check it out: www.sciencedirect.com/science/arti... #mentalhealth

Transcriptomic signatures and neural cell composition in schizophrenia iPSC-derived neuron cultures

Schizophrenia is a neurodevelopmental disorder associated with alterations in neuronal function and connectivity. It has been extensively modeled usin…

sciencedirect.com

An aptly titled paper shows, for the first time, the significance of heterogeneities of gene expression in the construction of complex systems : fate decisions are group decisions. Previously @biorxivpreprint cell.com/cell/fulltex... #MustRead #Gastruloids @Jshendure lab

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348

Enhancer binding kinetics explain transcription factor hub formation

Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...

tinyurl.com

Happy #FluorescenceFriday. This video shows a group of neural crest cells (🟣) remodelling a mesh of fibronectin matrix (🔵). This is part of a biorxiv paper showing the reciprocal relationship between NC and neural tube morphogenesis. 📹: Kai Weißenbruch, UCL 👇👇👇 www.biorxiv.org/content/10.6...

#Macrophages are mechanosensitive cells. They respond to mechanical signalling from the surrounding tissue, such as during fibrosis. In this review, the authors discuss the significance of the macrophage-fibroblast communication in a profibrotic niche. #immune 👇 www.sciencedirect.com/science/arti...

Happy #FluorescenceFriday. This video shows a group of neural crest cells (🟣) remodelling a mesh of fibronectin matrix (🔵). This is part of a biorxiv paper showing the reciprocal relationship between NC and neural tube morphogenesis. 📹: Kai Weißenbruch, UCL 👇👇👇 www.biorxiv.org/content/10.6...

How do long-lived multipotent stem cells cope with mechanical stress in vivo? We found that neural crest cells are protected from mechanical stress during migration in confined tissue environment. www.nature.com/articles/s41...

In vivo DNA damage protection during cell migration across confining embryonic tissue environments - Nature Cell Biology

Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

nature.com

#optogenetics is getting attention!! Welcome aboard the Opto-train 🚄🚂

Cells & Development@cellsdev.bsky.social · 2w ago

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

#optogenetics is getting attention!! Welcome aboard the Opto-train 🚄🚂

Cells & Development@cellsdev.bsky.social · 2w ago

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

Woah, such an invaluable resource! You can use this for your lectures too and can make a good resource for students! 🙌

Physical Biology of Developing Systems@pbodslab.bsky.social · 2w ago

An interdisciplinary #embryology book is out as #OER: @ecampusontario.bsky.social ecampusontario.pressbooks.pub/principlesof... A teamwork turned raw lecture recordings into a colloquial writeup. Please pass any feedback & critiques! @isdb.bsky.social @swedbo.bsky.social @socdevbio.bsky.social 🧪🔬

An interdisciplinary #embryology book is out as #OER: @ecampusontario.bsky.social ecampusontario.pressbooks.pub/principlesof... A teamwork turned raw lecture recordings into a colloquial writeup. Please pass any feedback & critiques! @isdb.bsky.social @swedbo.bsky.social @socdevbio.bsky.social 🧪🔬

Principles of Development - An inquisitive journey into embryology -

This textbook covers key concepts of embryology and principles of development in an understandable but detailed enough pace for advanced undergraduate students. Intended audience is advanced (3rd/4th ...

ecampusontario.pressbooks.pub

Are #cilia still hot or ... 👀? Maybe it's time to learn how they are formed! This review by the Pereira lab discusses the structural composition of the distal appendages, how they form the cilia, and how they are regulated in cell cycle and in diseases! www.sciencedirect.com/science/arti...

Great new study from @knoblich-lab.bsky.social, led by @saku-wong.bsky.social, showing that human cerebral organoids cultured for over six months can recapitulate postnatal interneuron migration 🧪🧬🧫🧠 www.biorxiv.org/content/10.6...

Cerebral organoids recapitulate interneuron chain migration in the human cortex

The human brain is incomplete at birth, with streams of late-born interneurons migrating into the postnatal cortex. This process is absent in rodents, limiting mechanistic investigation to post-mortem...

biorxiv.org

CLOK: Truly beautiful new #zebrafish tool for birthdating neurons from the Koyama and Del Bene labs doi.org/10.1038/s415...

CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration - Nature Neuroscience

Faini et al. develop CLOK, a method that labels neurons across a spectrum of colors according to when they were born, allowing successive generations of brain cells to be tracked as they take shape in...

doi.org

Epigenetics News - Old hearts age backwards: transplanted organs adjust to host's biological age www.nature.com/articles/d41... #Epigenetics #News #Aging #Transplant --- Cancer, immunology, and aging; epigenometech.com

Old hearts age backwards: transplanted organs adjust to host’s biological age

Tracking the biological age of grafted organs suggests that donor pools could be expanded to boost organ availability.

nature.com

Why does the same virus kill one host and spare another? The key is lung imprinting from a previous parasitic infection. Our new study @nature.com offers answers + critical mechanisms! Immense thanks to @KamalmKhanna and our collaborators. 🧵 #Diseasetolerance #NAMs www.nature.com/articles/s41...:

Type 2 immune history trains lung macrophages for viral disease tolerance - Nature

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

nature.com

☕Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human #meninges and perform comparative studies with #meningioma data. www.nature.com/articles/s41...

Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas - Nature Cell Biology

Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human meninges and perform comparative studies with meningioma data.

nature.com

#DBfeature #LatestResearch 🐠👁️ Regenerated fish retinas are similar to undamaged retinas, but display local patterning errors in comparison with undamaged retinas; new models could test their functionality recovery. By Deborah L. Stenkamp doi.org/10.1016/j.ydbio.2026.07.009

Our latest study about how stratified myosin motors at the plasma membrane drive distinct nanoscale clusters that organize into segregated mesoscale active emulsions is out in Science Advances! Read on to find out more| Science Advances www.science.org/doi/10.1126/...