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Benjamin Springstein

@huepfkiesel.bsky.social

Cyanos = green

3 Posts76 Follower112 Folgt
Andrea Vettiger@avettiger.bsky.social · 3mo ago

Excited to see our story published in @natmicrobiol.nature.com today! It’s been a long journey. We answered a major outstanding question: why does E. coli encode two aPBPs, yet only one plays a critical role in ensuring reliable PG fortification during cell division?

Paula Navarro@navarropaula.bsky.social · 3mo ago

🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇

Carballido-López's lab@carballido-lab.bsky.social · 3mo ago

And two more pre-prints from the lab, focusing on MreB polymerization cycle and dynamics! www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

A genetic screen unveils the polymerization cycle of the bacterial actin-like MreB

MreB, a bacterial actin homologue that organizes cell wall synthesis in most rod-shaped bacteria, assembles into membrane-associated filaments through mechanisms that have remained elusive despite dec...

biorxiv.org

Miloš Tišma@tismaa.bsky.social · 3mo ago

I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10

Chromosome topology gates productive RecA homology search

In homologous recombination, DNA repair depends on recombinase filaments finding homologous templates on chromosomes whose topology is continually remodeled by replication and transcription. How dynam...

biorxiv.org

Gregor Weiss@weiss-lab.bsky.social · 6mo ago

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

Stella Hurtley@smhsci.bsky.social · 6mo ago

Out now in @science.org Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape

Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In m...

science.org

Alex Bisson@archaeon-alex.bsky.social · 10mo ago

I am (months) late, but you HAVE TO read @huepfkiesel.bsky.social (there is an update version). How can ParM "turned MreB” in cyanos? shorturl.at/JXMjy This will become a classic. Such a clear example of homology =/= function. We need more studies to collect larger sample sizes to test it.

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape

Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low-copy plasmids. In multicel...

shorturl.at

Martin Loose@nartimsoole.bsky.social · 11mo ago

Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings! Preprint: www.biorxiv.org/content/10.1...

Charge segregation in the C-terminal linker of FtsZ enables Z-ring scaling with prokaryotic cell width

Bacterial cytokinesis is orchestrated by the Z-ring, a cytoskeletal structure formed by treadmilling filaments of the tubulin-like GTPase FtsZ. During assembly, filament curvature must match the cell ...

biorxiv.org

Florian Schur@schurlab.bsky.social · last yr.

Great work by Benjamin Springstein @huepfkiesel.bsky.social and the lab of Martin Loose @nartimsoole.bsky.social. Really stunning finding of the evolutionary repurposing of a DNA segregation machinery into a cell shape cytoskeletal system in cyanobacteria. Make sure to have a look!

Martin Loose@nartimsoole.bsky.social · last yr.

One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...

Martin Loose@nartimsoole.bsky.social · last yr.

One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...

Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape

Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...

biorxiv.org