🚨 Last seats available! Join our online course Bioinformatic Analysis of #TransposableElements, 2–6 November. Learn TE discovery, annotation, manual curation, insertion polymorphism and differential expression with @valentinapeona.bsky.social @clementgoubert.bsky.social & @ritarebollo.bsky.social

The new GraffiTE v1.1 is out 🎉 github.com/cgroza/Graff... Find, annotate and genotype polymorphic TE insertions, now with epigenetic mapping, thanks to @cgroza.bsky.social's magic 🪄 Enjoy!

It's live! The next @embo.org #EvoChromo meeting will take place next year October in St Feliu de Guíxols (Spain), check it out here: meetings.embo.org/event/27-chr.... It's been great to co-organise with @dodonova-sveta.bsky.social @kellervalsecchi.bsky.social @cedricfeschotte.bsky.social & Nick I.

Chromatin evolution from molecules to genomes

Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

meetings.embo.org

FYI: New online! The mechanistic and evolutionary diversity of programmed DNA elimination

The mechanistic and evolutionary diversity of programmed DNA elimination

Nature Reviews Genetics, Published online: 08 September 2026; doi:10.1038/s41576-026-01004-7Programmed DNA elimination is a developmentally regulated process in which specific DNA sequences are reproducibly removed from particular cell lineages. Here, the authors review the mechanistic diversity and evolutionary dynamics of DNA elimination, spanning chromosome breakage, whole-chromosome elimination and whole-genome elimination.

dlvr.it

My lab @ Edinburgh university is recruiting a postdoc to work on the weird and wonderful germline-specific chromosomes of flies. elxw.fa.em3.oraclecloud.com/hcmUI/Candid... collaboration with @germline.bsky.social and yukiko yamashita funded by @novonordisk.bsky.social please repost!

📢 Institut Jacques Monod Seminar 📅 September 18th 📍Institut Jacques Monod Next week, Prof. Omaya Dudin ( @dudinlab.bsky.social ) will present an Institut Jacques Monod seminar on the theme "Exploring multicellular developmental programs at the root of animals and beyond" ➡️ buff.ly/mY66omK

We are recruiting a PhD student 🥼🙋 Topic: how germ cells bend gene expression dogmas Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 info on the project and how to apply👇 mbg.au.dk/en/peter-and... I'd really appreciate it if you'd help spread the word. Thanks

Ever wondered why diverse organism shrink their genome in specific cells? We try to make sense of these curious cases of programmed DNA elimination in a review that came out today @naturerevgenet.bsky.social trebuchet.public.springernature.app/get_content/... @sandraduharcourt.bsky.social

Very happy to see our Nature Reviews Genetics article on programmed DNA elimination across eukaryotes out! A fantastic collective effort with an amazing group of colleagues, born from inspiring discussions at the Fondation des Treilles. rdcu.be/tmvKgsPZNhBa @laurarossevo.bsky.social

Nature Reviews Genetics@natrevgenet.nature.com · 2mo ago

New online! The mechanistic and evolutionary diversity of programmed DNA elimination

All co-lead by 🌟 Thomas Høgsbro Grønbæk & Marianne Yoth (@marianneyoth.bsky.social) 🌟 ..with help from Artem Ilin (@adc34.bsky.social), Anja Ebert, Marina Giovannetti and Tamsin Samuels in a fun and exciting long-standing collaboration with Felipe Teixeira (@felipekteixeira.bsky.social) /fin

A developmental switch in the piRNA pathway ensures stage-specific transposon silencing

Animal fertility and germ cell genome integrity is protected by the Piwi-interacting RNA (piRNA) pathway. While germline development unfolds through profoundly different chromatin and transcriptional ...

biorxiv.org

Open position in our lab for a research engineer. The applicant must hold a PhD in life sciences and have demonstrable experience in molecular biology and biochemistry. For more info: emploi.cnrs.fr/Offres/CDD/U...

Institut Jacques Monod@ijmonod.bsky.social · 3mo ago

#JobOffer 💼 Research Engineer (M/F) 📆 October 15th 📍Institut Jacques Monod, @sandraduharcourt.bsky.social 🔗 emploi.cnrs.fr/Offres/CDD/U...

Next summer's Epigenetics GRC (I'm co-chairing with Deborah Bouch'is) is shaping up nicely with an all-star lineup of speakers working on a broad range of organisms and systems and everything from molecular mechanisms to new phenomena. Apply and put it on your calendar! www.grc.org/epigenetics-...

👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...

Please join the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination in Roscoff, France. Deadline for abstract submission extended to May 20, 2026. cjm.sb-roscoff.fr/en/conferenc...

@sandraduharcourt.bsky.social · 6mo ago

The Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination is approaching. There are selected talk slots available. Abstract submission deadline: Tuesday, May 5, 2026.

Thank you @cnrsbiologie.bsky.social for the highlight on our recent publication!

CNRS Biologie@cnrsbiologie.bsky.social · 6mo ago

#ResultatScientifique🔎| Dans une étude publiée dans BMC Biology, des scientifiques révèlent que les extrémités des chromosomes germinaux chez la paramécie sont éliminées par un mécanisme inédit. ✍️ Sandra Duharcourt & Linda Sperling buff.ly/U9pshl7

✍️ The Duharcourt Lab ( @sandraduharcourt.bsky.social ) published a new article 📖 Genome biology 📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium 🔗 buff.ly/Wn5OD0c ⬇️ Scientific news published by @cnrsbiologie.bsky.social

CNRS Biologie@cnrsbiologie.bsky.social · 6mo ago

#ResultatScientifique🔎|Activer pour mieux réprimer ? Chez la paramécie, la transcription aide à verrouiller le génome contre les éléments mobiles🧬 ✍️ @sandraduharcourt.bsky.social 📕 Genome Biology ▶️ buff.ly/RgSZhfQ 🤝 @ijmonod.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social @cnrs.fr

Thank you @cnrsbiologie.bsky.social for the highlight (in French) of our work www.insb.cnrs.fr/fr/cnrsinfo/...

Une marque épigénétique qui active pour mieux réprimer

Chez les eucaryotes, la marque épigénétique H3K27me3 est classiquement associée à la répression transcriptionnelle.

insb.cnrs.fr

The Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination is approaching. There are selected talk slots available. Abstract submission deadline: Tuesday, May 5, 2026.

@sandraduharcourt.bsky.social · 8mo ago

Excited to announce the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination (Sept 21–25, 2026): cjm.sb-roscoff.fr/en/conferenc... Organized by @laurarossevo.bsky.social and myself.

#JobOffer 💼 Ingénieur d’étude H/F en biologie moléculaire 📍Institut Jacques Monod, @mnprioleau.bsky.social Lab 📆 1e juillet 2026 Candidatez sur le portail emploi CNRS avant le 13 mai 2026 🔗 emploi.cnrs.fr/Offres/CDD/U...

now published at BMC Biology! rdcu.be/fdITD

@sandraduharcourt.bsky.social · 12mo ago

Excited to share our new preprint on BioRxiv! A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1... 1/5

#ESR #VeilleESR Tribune de la C3N du #CNRS signée par plus de 700 scientifiques (membres du comité national, directrices et directeurs d'unités) pour alerter une nouvelle fois sur les conséquences des coupes budgétaires c3n-cn.fr/2026/04/10/b...

✍️ The @sandraduharcourt.bsky.social Lab published a new article 📖 Genome Biology 📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium 🔗 link.springer.com/article/10.1...

@sandraduharcourt.bsky.social · 7mo ago

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

Our latest publication is out! @narjournal.bsky.social academic.oup.com/nar/article-...

Transcription at an inducible common fragile site reveals replication origin strength hierarchy

Abstract. While genome-wide analyses in vertebrates suggest that transcription negatively regulates replication origin activation, thereby shaping the land

academic.oup.com

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology

Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

link.springer.com

Our work on chromatin evolution in brown algae is now published in @natecoevo.nature.com! We show that developmentally complex brown algae evolved without epigenetic silencing pathways long thought universal, underscoring why non-model lineages are important to study. www.nature.com/articles/s41...

#JobOffer 💼 Professeur en stabilité du génome 📍Institut Jacques Monod 📆 1e septembre 2026 Les candidatures sont ouvertes jusqu'au 3 avril 2026 16h🔗 u-paris.fr/recrutement-...

I had fun writing this N&Vs on two fascinating new papers on centromere evolution in yeast. If you’re interested in how centromeres adapt yet stay functional, here’s my take. rdcu.be/e6DD0 @nature.com @gautamdey.bsky.social @gsherloc.bsky.social @helsenjana.bsky.social @maxhaase.bsky.social

Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social : www.biorxiv.org/content/10.6...

Excited to announce the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination (Sept 21–25, 2026): cjm.sb-roscoff.fr/en/conferenc... Organized by @laurarossevo.bsky.social and myself.

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...