We’ve mapped the Achilles tendon at single-cell resolution 🧬 — revealing 6 fibroblast types with distinct roles across muscle–tendon zones. A new atlas for understanding injury + repair. Find our more in our new preprint www.biorxiv.org/content/10.1... #Tendon #CellAtlas #SpatialTranscriptomics

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon

Tendons are transitional tissues linking muscle to bone, enabling locomotion and fine motor control. The cellular biology across the Achilles tendon unit is poorly understood, yet critical for interpr...

biorxiv.org

Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.

Dr Sarah Snelling @sarahsnelling.bsky.social is leading a new study aiming to develop a blood test that could identify markers of osteosarcoma. This could be game-changing for early detection of this disease.

Annemarie’s latest paper is out today! CYR61 delivery promotes angiogenesis during bone fracture repair. www.nature.com/articles/s41... @amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.

CYR61 delivery promotes angiogenesis during bone fracture repair - npj Regenerative Medicine

npj Regenerative Medicine - CYR61 delivery promotes angiogenesis during bone fracture repair

nature.com

Fibroblasts & endothelial cells appear to orchestrate the early response to injury in ruptured quads tendons. Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team. physoc.onlinelibrary.wiley.com/doi/10.1113/...

Join us online for the @humancellatlas.bsky.social Musculoskeletal Bionetwork seminar on 21st May at 4pm GMT. We're excited to hear about spatial mechano-transcriptomics from Dr Adrien Hallou @halloulab.bsky.social Open to all interested in MSK atlases in any species! Register now bit.ly/4jhakA8

Ever torn a tendon? Our study led by @joletmimpen.bsky.social discovered changes in fibroblast and immune cell populations that occur in quadriceps tendon tears. Read more: doi.org/10.1113/JP28... @sarahsnelling.bsky.social @adamcribbs.bsky.social

Calling clinicians, research nurses, lab scientists & bioinformaticians! Please fill out our short survey on challenges & enablers for #biobanks & #Omics research. Respondents from #GlobalSouth & #LMICs especially welcome! @ndorms.bsky.social @humancellatlas.org bit.ly/41nHHex

Biobanks and 'Omics amongst international clinicians and researchers

bit.ly

Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social www.cell.com/cell/fulltex...

This is very cool! www.nature.com/articles/s41...

Distinct gene regulatory dynamics drive skeletogenic cell fate convergence during vertebrate embryogenesis - Nature Communications

Vertebrate skeletogenic cells of different embryonic origins are distinct cell types, based on their lineage-specific gene regulatory logic that specifies them, and the potential for individualized ev...

nature.com

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻 #macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social www.biorxiv.org/content/10.1...

Macrophages promote collagen deposition through circadian regulation of fibroblasts

Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

biorxiv.org

It had to be done! I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!

I cannot think of anyone more deserving than Megan Killian (@megankillian.bsky.social) for the Community Council Chair on the ORS Board of Directors ballot 😍 Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇 t.co/h60xhz38NN

If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you! boneandjoint.org.uk/Article/10.1...

Dr Jolet Mimpen@joletmimpen.bsky.social · 2y ago

It is great to finally share our systematic review on structural extracellular matrix components in soft tissues in osteoarthritis! Congratulations to my co-authors Iwan Raza and @sarahsnelling.bsky.social. boneandjoint.org.uk/Article/10.1...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

A panoramic view of cell population dynamics in mammalian aging

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

tinyurl.com

Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation! We can teach it all off 1 paper! 1. Woo 2. Hoooo!!! H/t @lianafaye.bsky.social www.biorxiv.org/content/10.1...

Molecular and genetic characterization of sex-linked orange coat color in the domestic cat

The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...

biorxiv.org

Thinking of doing a DPhil/PhD? Then take a look at this! www.ndorms.ox.ac.uk/news/blog/st... The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team. From my perspective it's hugely fun & I'm always learning!

📢 Preprint! How does the environment of a father before conception influence offspring? Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales🧵... www.biorxiv.org/content/10.1...

Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds

The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

biorxiv.org

Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg

My first post on bsky☺️ The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage www.oarsijournal.com/article/S106...

Osteoarthritis year in review 2024: Biology

Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which a substantial increase in knowledge has been achieved over the last year. It covers many different topics, however, a ...

oarsijournal.com

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)