Really fortunate to continue this collaboration with @shenzhichen1999.bsky.social and @alex-stark.bsky.social while back in medical school and scratch the research itch. Still can't believe the model achieved 15/15 target tissues!

Evgeny Kvon@evgenykvon.bsky.social · 4w ago

First synthetic mouse enhancers active in defined embryonic tissues! Great collaboration led by @alex-stark.bsky.social lab now at @natgenet.nature.com

🔔This Wednesday we are excited to have three amazing ECR talks at #FragileNucleosome by Ujani, @ewholling.bsky.social & @germainekaram.bsky.social ! Don't forget to subscribe to our series! us06web.zoom.us/webinar/regi...

It’s not about drugs. If it was, Trump wouldn’t have pardoned one of the largest narco traffickers in the world last month. It’s about oil and regime change. And they need a trial now to pretend that it isn’t. Especially to distract from his sinking under Epstein and skyrocketing healthcare costs.

From synthetic sequence to mammalian tissue-specific activity?! 🤯 Loved contributing to this awesome collaboration with @shenzhichen1999.bsky.social, Vincent Loubiere, @alex-stark.bsky.social, @evgenykvon.bsky.social, @jmschreiber91.bsky.social. So many possibilities in this space!

Alex Stark@alex-stark.bsky.social · 9mo ago

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

A call to arms for research universities "We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."

Vijay G. Sankaran@bloodgenes.bsky.social · last yr.

www.nytimes.com/2025/09/08/o...

The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...

Opinion | America First? Not When It Comes to Your Health.

nytimes.com

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

Exactly 7 years (to the day) after packing my car up and leaving for California, I successfully defended my PhD in the the lab of @evgenykvon.bsky.social! Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

nature.com

Huge congrats to @gracebower.bsky.social & @evgenykvon.bsky.social on the lab's recent Nature paper! A lot of fun to contribute to this project and watch the story develop over the past several years

Evgeny Kvon@evgenykvon.bsky.social · last yr.

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Main story of my PhD with @evgenykvon.bsky.social in preprint! See thread and link for all the details!

Evgeny Kvon@evgenykvon.bsky.social · last yr.

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/