J. Andrew N. Alexander

@j-a-n-alexander.bsky.social

Postdoctoral researcher at @ethz.ch in the Locher lab🇨🇭 PhD alumnus of the Strynadka lab at the University of British Columbia 🇨🇦 Interested in medical mycology, glycobiology, structural biology and membrane proteins. https://orcid.org/0000-0002-8759-1389

Me too @lornamilne.bsky.social! Very excited to read everyone's abstracts! This is an amazing opportunity for early career researchers to expand their networks, gain exposure to different areas of research and get experience communicating their work.

Lorna Milne@lornamilne.bsky.social · last mo.

SO excited to be teaming up with @j-a-n-alexander.bsky.social to chair next years Glycobiology GRS! 🍬 Welcoming abstracts from all areas of #glycotime - we can't wait to see you all in Ventura! 🌞

🚨 Want to be part of top #glycotime on the seaside in the California sunshine? Register to the 2027 GRC Glycobiology ⬇️ Stacy and Lance put togteher up one of the most exciting programmes I have ever seen with phenomenal keynotes! We have 32 abstracts to select, so the next speaker could be YOU! 😎

Announcement of the GRC Glycobiology 2027 to be held in Ventura CA on March 14 to 19, 2027. Blue background with an photo of Ventura from the visitventuraca.com

We have some fresh and cool #glycotime 🧪 on the impact of including glycosylation explicitly in de novo binder design. Filtering the results of a recent open competition for novel binders to the Nipah Virus Glycoptrotein (NiV-G) with ReGlyco improves the pipeline efficiency significantly ⬇️

a. Structure of the Nipah Virus Glycoprotein (NiV-G) homotetramer (aa 92-602) reconstructed from cryo-EM structures (PDB 7TXZ and 7TY0) bound to broadly neutralising antibody nAH1.3 Fabs30 (not shown). Static (single) glycans 3D structures (shown with sticks in blue) were reconstructed with GlycoShape ReGlyco17, where the choice of the glycan type was guided by glycoproteomics analysis36. The visible six glycan sites on chains A, B and D are mapped onto the structure, while glycans on chain C are not labelled for clarity. b. Structure of the glycosylated NiV-G recostructured with GlycoShape ReGlyco Ensemble29 using 150 frames from the MD trajectories of each selected glycan. Rendering effect is obtained with a “long exposure” filter to reflect the glycan dynamics. Sterically constrained glycans and rigid regions of the saccharides can be identified by the darker blue colour. c. Structure of the glycosylated NiV-G as in panel b. but with each one of the 150 glycan frames shown in dark blue, to illustrate the potentially occluded volume of the NiV-G protein surface
GlycoShape@glycoshape.org · 6mo ago

Most biologics are glycosylated and some of them heavily. In this “fresh off the press" #glycotime preprint we look into how a filter that accounts for glycosylation explicitly in 3D can help reduce lab costs and increase the efficiency of de novo binder design pipelines. Short 🧵 ⬇️ 1/7

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

Biological Laboratory | LEGO® Ideas

This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

beta.ideas.lego.com

Very happy to have had the opportunity to present some unpublished research at the Biological Structures Group winter meeting in Oxford this past week. It’s always so inspiring to see and discuss cutting-edge science! And, Oxford, you really are a stunning town!

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