Very happy to see our Nature Reviews Molecular Cell Biology Roadmap out! A fantastic collective effort, led by Carsten Janke and Zdenek Lansky, together with an amazing group of colleagues, and sparked by inspiring discussions at the Fondation des Treilles. www.nature.com/articles/s41...

Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease - Nature Reviews Molecular Cell Biology

Microtubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key ...

nature.com

(1/4) Last, but not least: how do mitochondria look like with #MegaExM? First, thank you Jorge for providing your expertise in this topic and how to deal with all these data! He already shared what a 10X air lens can capture in his latest post. But what about 40X 1.2 NA water lens?

jorgetoledoh@jorgetoledoh.bsky.social · 4w ago

(1/5) Individual mitochondrial cristae with a 10X air lens 🤯 I am very happy to be a co-author on Mega-ExM! Driven by @igvegvas.bsky.social at @sauer-lab.bsky.social . It is really exciting to see how far Ignacio has pushed the technique since we learned it together back in 2019.

Structural cell biology by mega-expansion microscopy www.biorxiv.org/content/10.64898/2026.08.05.743040v1 #cryoEM

(1/5) Individual mitochondrial cristae with a 10X air lens 🤯 I am very happy to be a co-author on Mega-ExM! Driven by @igvegvas.bsky.social at @sauer-lab.bsky.social . It is really exciting to see how far Ignacio has pushed the technique since we learned it together back in 2019.

(2/3) As an example, here's a first look at cilia and basal bodies in a multiciliated cell expanded 250x! A 1.25×1.25x0.59 mm volume (≈ 5×5x2.4 µm, PreExM), acquired with a 10X air lens (undersampled), but yet so much detail! Stainings: NHS (magenta) / CEP83 (cyan) / Acet. tub. (orange).

our 5th paper of 2026 is out: ONE microscopy www.nature.com/articles/s41... #Protein shapes, #sub-nanometer precision, conventional #fluorescence #microscopes, and now #ONEpy. 3 more papers in revision, more this year. We’re only getting started. #optical #structural #biology is becoming a field

(1/3) For all centrosome/cilia enthusiasts 🗣️🗣️ From Pereira’s lab, we’re so happy to share our latest collab with @sauer-lab.bsky.social: Mega-ExM)! 🥳 Here, we pushed expansion microscopy to crazy scales (1500x 🤯) and used cilia and centrioles as some of our favorite test structures 🤭

Ignacio Vega-Vásquez@igvegvas.bsky.social · last mo.

(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯

Centrosome/cilia people 🗣🗣 Multiciliated cells by Mega-ExM with a 10X air lens 😶‍🌫️ (Plan-Apochromat, 0.45 N.A.); voxel: 1.248 μm x 1.248 μm x 4 μm, sampling 0.21x. Airyscan2 LSM900 Zeiss. Thank you Camila and Gislene for this awesome collab!

Camila García-Navarrete@camig98.bsky.social · 4w ago

(2/3) As an example, here's a first look at cilia and basal bodies in a multiciliated cell expanded 250x! A 1.25×1.25x0.59 mm volume (≈ 5×5x2.4 µm, PreExM), acquired with a 10X air lens (undersampled), but yet so much detail! Stainings: NHS (magenta) / CEP83 (cyan) / Acet. tub. (orange).

Exciting new preprint from Ignacio Vega Vásquez, Sauer lab, my team and collaborators: #Mega-ExM. From just ~20 NPCs imaged with a 10× objective on a confocal, we reconstructed the 3D structure at ~33 Å. A step toward optical structural biology in intact cells. www.biorxiv.org/content/10.6...

(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last mo.

Structural cell biology by mega-expansion microscopy https://www.biorxiv.org/content/10.64898/2026.08.05.743040v1

Structural cell biology by mega-expansion microscopy https://www.biorxiv.org/content/10.64898/2026.08.05.743040v1

Excited to share our latest paper in Gislene Pereira’s lab about how extracellular matrix stiffness affect ciliogenesis c: check it out here: doi.org/10.1038/s415...

Soft matrix promotes ciliogenesis in human retinal pigment epithelial cells - Scientific Reports

Scientific Reports - Soft matrix promotes ciliogenesis in human retinal pigment epithelial cells

doi.org

www.protocols.io/view/cryo-ex... New protocol alert!! Cryo-expansion microscopy of C. elegans and Tardigrades using the high pressure freezer!

Cryo-Expansion Microscopy of C. elegans and Tardigrades

Cryo-Expansion Microscopy of C. elegans and Tardigrades. Expansion microscopy (ExM) improves imaging r. Read full protocol, steps, and materials on protocols.io

protocols.io

Thanksgiving update: Turkey’s brined. Pie’s baked. Pickle slice just hit metaphase. Breaks from cutting edge science? Never heard of ’em. Happy Thanksgiving y’all 🥒🔬🦃 #Thanksgiving #CellBiology #NerdHumor #Science

🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...

You can join this challenge to try and predict Alzheimer's pathology from transcriptomic data! www.synapse.org/Synapse:syn6... It launches July 27! #hackathon @alleninstitute.org

SEA-AD DREAM Challenge - Predicting Alzheimers Pathology from snRNA-seq Data

'SEA-AD DREAM Challenge - Predicting Alzheimers Pathology from snRNA-seq Data' (Synapse ID: syn66496696) is a project on Synapse. Synapse is a platform for supporting scientific collaborations cen...

synapse.org

Ready to dive into the world of "Fluorescence Bioimaging"? Here’s our starter pack! 🧪✨ Explore colleagues working on tools, techniques, and tips to illuminate biology at the nanoscale. #Bioimaging #FluorescenceMicroscopy #SuperResolution go.bsky.app/Dns7H6k

🚨 New #Blueprint🚨 Ever wondered how the HPC supports learning across different contexts? My newest, a combo of experimental and comp neuro, w @SaraASolla & @DisterhoftLab, uncovers a 'universal' memory code in the HPC—consistent across animals and environments! 🧵👇 www.biorxiv.org/content/10.1...

A universal hippocampal memory code across animals and environments

How learning is affected by context is a fundamental question of neuroscience, as the ability to generalize learning to different contexts is necessary for navigating the world. An example of swift co...

biorxiv.org

I just created a Microscopy feed that tracks anything that has a cute 🔬 emoji on it as well as the simple #microscopy and #imaging tags. Enjoy! bsky.app/profile/did:...

A mapping of how Bluesky is becoming the new Scientific Twitter mikeyoungacademy.dk/bluesky-is-e...

Bluesky is emerging as the new platform for science - Mike Young Academy

Scientific Twitter is about to find its true successor. And it is not X. This, our latest release, shows that the Bluesky network of scientists is growing — and growing.

mikeyoungacademy.dk

Direct streaming of an #OMERO dataset in #BigDataViewer from the public server omero-tim.gerbi-gmb.de (dataset from the Workshop 35). Thank you Tom and @gerbi.bsky.social !

Hello, I'm a way to save bookmarks until we get a real bookmarking feature. Just DM me a post by tapping the three dots on the bottom right and selecting 'Send via direct message'. Type my handle (@bookmarkit.bsky.social) to find me and send me the post. You can practice on this post if you like 🔖

It took us three years to build up a community on X. Please help us find our community here, too 🤗 #academia

New paper in Imaging Neuroscience by Davood Karimi and Simon K. Warfield: Diffusion MRI with machine learning doi.org/10.1162/imag...

New paper in Imaging Neuroscience by John C. Williams, Jared X. Van Snellenberg, et al: Functional localization of the human auditory and visual thalamus using a thalamic localizer functional magnetic resonance imaging task doi.org/10.1162/imag...