Claire McCarthy
@clairem402.bsky.social
scientist with a PhD in toxicology | views are my own
#BookChallenge for September: 30 books that you’ve read in 2026 so far. #BookSky 6/30 en.wikipedia.org/wiki/The_Nam...
The Namesake (novel) - Wikipedia
en.wikipedia.org
Claire McCarthy@clairem402.bsky.social · yesterday#BookChallenge for September: 30 books that you’ve read in 2026 so far. #BookSky 5/30
This is sooo cool! This new technology kicks up observing cell function up a notch. Much of our analyses involves killing cells before downstream analyses. The best way to study cells is to watch them do their thing in real time! 🧪 news.mit.edu/2026/new-met...
New method allows scientists to follow gene activity over time in the same cells
Researchers at MIT and the Broad Institute of MIT and Harvard invented a “cellular self-reporting” approach to make living cells share their own transcriptomes, so that scientists can analyze them wit...
news.mit.edu
Very pleased to see our paper describing the MultiMuTHER study published in @science.org this week! A huge thank you to all TwinsUK volunteers who have contributed samples and time over so many years, and the TwinsUK team who make studies like this possible. @kerrinsmall.bsky.social
Longitudinal dynamics of gene expression and metabolomics in an aging population cohort
Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...
science.org
Neutrophils remodel their actin cytoskeleton rapidly as they navigate narrow capillaries of varying sizes, enabling them to squeeze through without causing blockages. Learn more in #ScienceImmunology: https://scim.ag/4xwpB7e
Nancy Grace Roman - honoured by the newest telescope in space - spearheaded a pioneering programme as NASA’s first chief astronomer, says Robert W. Smith go.nature.com/4A1qQgu
‘Mother of Hubble’: how Nancy Grace Roman ushered in a new era of astronomy
The scientist honoured by the newest telescope in space spearheaded a pioneering programme as NASA’s first chief astronomer.
go.nature.com
Safeguarding biomedical data while enabling researcher access remains a challenge go.nature.com/4A37SpK
A data leak shut a top research biobank: lessons from the recovery
The UK Biobank is imposing new safety measures after a security incident, but safeguarding biomedical data while enabling researcher access remains a challenge.
go.nature.com
New research from National Academy of Sciences and National Academy of Medicine member Stanley Cohen and colleagues describes a microvesicle-based platform that delivers gene-silencing RNA, a step toward improving RNA-based therapeutics. In PNAS Nexus: https://ow.ly/3Ypl50ZKPjq
#BookChallenge for September: 30 books that you’ve read in 2026 so far. #BookSky 4/30 en.wikipedia.org/wiki/Sunrise...
Sunrise on the Reaping - Wikipedia
en.wikipedia.org
Claire McCarthy@clairem402.bsky.social · 3d ago#BookChallenge for September: 30 books that you’ve read in 2026 so far. #BookSky 3/30
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)
Pressure-sensitive switches amplify fibrosis: doi.org/10.1172/JCI1... Kadri et al. @helmholtzmunich.bsky.social charted phosophoproteome dynamics across physiological stiffnesses to identify NFATC4 as a mechanosensitive driver of myofibroblast fate and a candidate target in multi-organ fibrosis.
"The deepest returns on basic research are frequently the ones that could not have appeared in the original proposal. Roman itself makes this argument almost poetically." go.nature.com/3UuFWuI
NASA’s Roman telescope holds promise far beyond mapping the invisible Universe
Discovery flourishes when instruments, ideas and people come together in unpredictable ways.
go.nature.com
A newly discovered function for this protein explains why inhibiting cell division can enhance the signalling mediated by the oestrogen receptor that drives breast cancer go.nature.com/4ynHB3G
The secret life of a cell-cycle gatekeeper of breast cancer
A newly discovered function for the protein Rb explains why inhibiting cell division can enhance the signalling mediated by the oestrogen receptor that drives breast cancer.
go.nature.com
Just two doses of psilocybin administered before chemotherapy completely prevented mice from developing neuropathy go.nature.com/3Vg19sq
Magic-mushroom compound blocks a severe side effect of chemotherapy, in mice
Study shows that psilocybin acts on nerves to prevent the painful condition called peripheral neuropathy.
go.nature.com
Soundscapes of ancient forests are made possible through reconstructions of the sound-producing structures of insects from the Jurassic period. These ancient relatives of today’s katydids lived in what is now Inner Mongolia, China. In PNAS: https://ow.ly/xee550ZISxP
How do #microplastics move through water and land? #EarthScientists find ways to track their journey with an eye toward #remediation. In PNAS Front Matter: https://ow.ly/xlFh50ZJsxk
Share a COMEDY movie title that begins with the letter “F” 🎥 F is for… Friday 💙
Friday
ALT: Friday
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Amy Koto, TV Fanatic Girl@tvfanaticgirl.bsky.social · 3d agoShare a COMEDY movie title that begins with the letter “F” 🎥 F is for… Forgetting Sarah Marshall 💙
The research was led by recent Ph.D. graduate Kausalya Mahadevan, who is now a postdoctoral associate in the lab of Katia Bertoldi, the William and Ami Kuan Danoff Professor of Applied Mechanics. #womeninstem www.sciencedaily.com/releases/2026/09/260901070543.htm
Harvard scientists turn knitting into shape-shifting smart fabric
Harvard researchers have transformed ordinary knitting into a platform for creating fabrics that can snap between different shapes and perform useful functions. Using elastic yarns and industrial knit...
sciencedaily.com
We asked readers to share stories about a moment of kindness involving a stranger. Here are some of their heartwarming anecdotes. n.pr/4gD4Qkm
Whatever happened to kindness? Spoiler alert: Our readers prove it's alive and well
We asked readers to share stories about a moment of kindness involving a stranger. Here are some of their heartwarming anecdotes.
n.pr
#BookChallenge for September: 30 books that you’ve read in 2026 so far. #BookSky 1/30 patrickryanbooks.com/books/buckeye/
Buckeye
Winner of the 2026 Ohio Book Award New York Times bestseller • Amazon’s Best Book of 2025 • Read With Jenna pick • New York Times Notable Book of the Year • Washington Post Notable Book of the Year…
patrickryanbooks.com
Just a lil’ spider, living in your books.@heavyheavensky.bsky.social · last wk.#BookChallenge for September: 30 books that you’ve read in 2026 so far. #BookSky 1/30
Why have antioxidant supplements not helped reduce the incidence of cancer and in some trials shown an increase? Suppression of T cell immune response to cancer @ScienceMagazine science.org/doi/10.1126/... science.org/doi/10.1126/...
MED4 acts as a gatekeeper, preventing metastatic reawakening in breast cancer. Its haploinsufficiency links to recurrence risk. PMID:42332201, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01984-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Mediator subunit MED4 enforces metastatic dormancy in breast cancer | Nature Cell Biology
Long-term survival in breast cancer is often limited by metastatic recurrence arising from disseminated cancer cells that persist in a dormant state. The mechanisms that enable these dormant cells to survive and subsequently reawaken remain incompletely understood. Here an unbiased genome-scale genetic screen identified Med4 as a cancer cell-intrinsic gatekeeper in metastatic reactivation. Correspondingly, MED4 haploinsufficiency was found to be prevalent in metastatic breast cancer and associated with poorer clinical outcomes. Syngeneic mouse metastasis models revealed that MED4 enforces metastatic dormancy. Mechanistically, and unexpectedly given the canonical role of the Mediator complex in transcriptional activation, MED4 suppresses enhancer priming (H3K4me1) and activation (H3K27ac). Loss of a single Med4 allele disrupts enhancer poise, leading to extracellular matrix remodelling and integrin-mediated mechanotransduction programmes that ultimately drive metastatic outgrowth. Toget
doi.org
Share a COMEDY movie title that begins with the letter “D” 🎥 D is for… Dodgeball
Dodgeball Team Celebrates Victory
ALT: Dodgeball Team Celebrates Victory
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Spidey Ramone@spideyramone.bsky.social · 5d agoShare a COMEDY movie title that begins with the letter “D” 🎥 D is for… Diary of a Wimpy Kid
