Great message from Jim Allison on how we need to keep doing science. Even nicer shoutout to JEM on the interplay between CTLA-4 and ICOS enhancing ICI (tinyurl.com/4rebxhuj and tinyurl.com/42fnrbvb). Attending the Keystone Immunotherapy? Come and say hi 👋 #KSCancerImmune26

ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype

The study unveils that potent combination therapies remodel TAMs to antitumor proinflammatory M1-like macrophages crucial for their therapeutic efficacy. I

tinyurl.com

For this month #JEMjc we would like to highlight this study from Eva Harris lab linking anti-NS1 IgA antibodies in plasma from a primary ZIKV infection, to drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease. More here: www.nature.com/articles/s41...

IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans - Nature Immunology

This study reveals that anti-NS1 IgA antibodies in plasma, induced by prior Zika virus infection, activate neutrophils, underlying severe dengue disease upon a subsequent DENV2 infection, uncovering a...

nature.com

It’s #JEM_Spotlight time again: this month we would like to highlight the detailed analysis of serological antibodies elicited after R21/Matrix-M malaria vaccine. Because, you know, vaccines work. doi.org/10.1084/jem.20241908

Happy New Year from all of us @jem.org. For this month’s #JEMLegacy we are going back to the 90s with this report on lymphotoxin’s role in chronic inflammation tinyurl.com/2ua2cezw

Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the JEM Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...

Following on from a great site visit at @cicbiogune.bsky.social last week, for #JEM_Spotlight I would like to highlight the work of @arkaitzcarracedo.bsky.social. A really interesting study investigating the role of LKB1 in metastatic prostate cancer. Take a look here 👉 doi.org/10.1084/jem....

And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...

In light of Monday’s #Nobel Prize in Physiology or Medicine announcement, for #JEMLegacy let’s look back at one of Shimon Sakaguchi’s early @jem.org papers from 1985! rupress.org/jem/article/...

For September’s #JEMjc we would like to highlight the recent description of septal macrophages controlling adipocyte tissue plasticity www.science.org/doi/10.1126/...

Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct lo...

science.org

Back to school, back-to-back #JEMLegacy with this study of neutralization tests for poliomyelitis in newborn infants and mothers…from 1930! tinyurl.com/59nnnuan

IMMUNITY TO POLIOMYELITIS IN MOTHERS AND THE NEWBORN AS SHOWN BY THE NEUTRALIZATION TEST

Neutralization tests for the virus of poliomyelitis on blood serum of urban mothers and their newborn infants showed that immunity was present in ten out o

tinyurl.com

Back to school time of year with this #JEM_Spotlight describing the γδ T cell profiling of pre-term infants as a first line of defense for neonates tinyurl.com/3hz73p2v

JEM's Deputy Editor Gaia Trincucci (@gaiajexpmed.bsky.social) and @rupress.org's Ben Short at #AAI2025! Today's our final day -- come by our booth #811 and say hi! Don't forget to pick up our latest Immunology collection 📚 + souvenir 🏝️

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj

Rod Rahimi@rodrahimi.bsky.social · 2y ago

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network Below are the links If you're an immunologist and I have missed you so far, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS

In new study, Simchoni et al. from Anthony Shum's lab (rupress.org/jem/article/...) compared five families and multiple generations to find a gene variant that prevents COPA Syndrome and opens the door to a new gene therapy for the condition. More from UCSF News: www.ucsf.edu/news/2025/02...

1 Gene Variant Is Poised to Cure a Devastating Inherited Disease

COPA syndrome causes lung hemorrhaging starting in childhood. But one in three people with the disease mutation are spared. UCSF scientists have discovered how a separate gene variant protects those r...

ucsf.edu

#RareDiseaseDay2025 @jem.org where we remain committed to publishing studies that identify inborn errors of immunity, elucidate underlying mechanisms and propose potential treatments for rare diseases. Some recent examples: doi.org/10.1084/jem.20240827 doi.org/10.1084/jem.20240843

KLF2 expression in IgG plasma cells at their induction site regulates the migration program, say Wataru Ise, Takuya Koike, Tomohiro Kurosaki @osaka_univ_e and colleagues: buff.ly/41bbKEF

Tomorrow is #RareDiseaseDay. An exciting discovery today for COPA syndrome, a rare heritable autoimmune disease. Finding a protective allele that has the potential to lead to a cure rupress.org/jem/article/...

Tejedor Vaquero, Neuman et al. @gmagrilab.bsky.social demonstrate immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease. https://buff.ly/4jVJYV5 📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

Kellog, @reboldilab.bsky.social, Vanni et al. reveal that #microbiome-driven tuft cells’ hyperplasia in the colon helps defend against Clostridioides difficile infection. https://buff.ly/3CRIPNy 📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

Mike Lauer follows Lawrence Tabak out the door at NIH www.statnews.com/2025/02/13/n...

Second top NIH official, who oversaw awarding of research grants, departs abruptly

Michael Lauer, deputy director of the National Institutes of Health’s extramural research, will leave the agency at the end of the week.

statnews.com

Suin Jo, Kenneth Murphy et al. @washumedicine.bsky.social utilize several genetic models to distinguish roles of cDC1 and cDC2 in presentation of different forms of antigens to CD4⁺ and CD8⁺ T cells in vivo. https://buff.ly/42LUFDr

1/ Spots are still open for the 2025 Henry Kunkel Society Meeting on Genes & Immunity! Join us in Belgrade from April 10-12, 2025. www.henrykunkelsociety.org/meetings/ #HKS2025 #Immunology 🧬🔬

NIH plans to slash support for indirect research costs, sending shockwaves through science Capping these payments would ‘just grind our scientific complex to a halt,’ one researcher said @statnews.com www.statnews.com/2025/02/07/n...

NIH plans to slash support for indirect research costs, sending shockwaves through science

The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%

statnews.com

Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N

“It will be much easier to destroy the world’s greatest scientific ecosystem than it will be to try to rebuild it” Scientists are worried about the long-term effects of the Trump administration’s actions https://go.nature.com/3PUKeGc

Chaos erupts in US science as Trump’s team declares freeze on federal grants

The freeze’s effect on research is still unclear, but scientists fear ‘incalculable’ damage.

go.nature.com

We’re thrilled to announce our partnership with the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) to launch the Journal of Human Immunity (JHI) @jhumimmunity.org (https://buff.ly/3PAEMrK)! Groundbreaking, #OpenAccess research on #HumanImmunity 👉 https://buff.ly/4ajqm8W

Our January Issue is here ✨ https://buff.ly/3W45Raw The image shows CD206+ #macrophage population marked by Venus expression (yellow) in B78chOVA tumor slices with transferred OT-I T cells marked by CD2dsRed (red). From Arja Ray, @maxkrummel.bsky.social et al. (https://buff.ly/3DHWwPl)

Our annual "Best of JEM" series highlights some of the most exciting studies from the last 12 months. We present you with research in basic #immunology, #immunotherapy and tumor immunology, inborn errors of immunity, #neurodegeneration, & #inflammation: https://buff.ly/4iwWcCJ

Breaking news: A 2020 paper that sparked widespread enthusiasm for hydroxychloroquine as a #COVID19 treatment has been retracted, following campaigning by scientists who alleged the research contained major scientific flaws and may have breached ethics regulations. scim.ag/4iR9bQ6

Infamous paper that popularized unproven COVID-19 treatment finally retracted

Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds

scim.ag