Open position in our lab for a research engineer. The applicant must hold a PhD in life sciences and have demonstrable experience in molecular biology and biochemistry. For more info: emploi.cnrs.fr/Offres/CDD/U...

Institut Jacques Monod@ijmonod.bsky.social · 6d ago

#JobOffer 💼 Research Engineer (M/F) 📆 October 15th 📍Institut Jacques Monod, @sandraduharcourt.bsky.social 🔗 emploi.cnrs.fr/Offres/CDD/U...

Next summer's Epigenetics GRC (I'm co-chairing with Deborah Bouch'is) is shaping up nicely with an all-star lineup of speakers working on a broad range of organisms and systems and everything from molecular mechanisms to new phenomena. Apply and put it on your calendar! www.grc.org/epigenetics-...

👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...

Please join the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination in Roscoff, France. Deadline for abstract submission extended to May 20, 2026. cjm.sb-roscoff.fr/en/conferenc...

@sandraduharcourt.bsky.social · 3mo ago

The Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination is approaching. There are selected talk slots available. Abstract submission deadline: Tuesday, May 5, 2026.

Thank you @cnrsbiologie.bsky.social for the highlight on our recent publication!

CNRS Biologie@cnrsbiologie.bsky.social · 3mo ago

#ResultatScientifique🔎| Dans une étude publiée dans BMC Biology, des scientifiques révèlent que les extrémités des chromosomes germinaux chez la paramécie sont éliminées par un mécanisme inédit. ✍️ Sandra Duharcourt & Linda Sperling buff.ly/U9pshl7

✍️ The Duharcourt Lab ( @sandraduharcourt.bsky.social ) published a new article 📖 Genome biology 📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium 🔗 buff.ly/Wn5OD0c ⬇️ Scientific news published by @cnrsbiologie.bsky.social

CNRS Biologie@cnrsbiologie.bsky.social · 3mo ago

#ResultatScientifique🔎|Activer pour mieux réprimer ? Chez la paramécie, la transcription aide à verrouiller le génome contre les éléments mobiles🧬 ✍️ @sandraduharcourt.bsky.social 📕 Genome Biology ▶️ buff.ly/RgSZhfQ 🤝 @ijmonod.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social @cnrs.fr

Thank you @cnrsbiologie.bsky.social for the highlight (in French) of our work www.insb.cnrs.fr/fr/cnrsinfo/...

Une marque épigénétique qui active pour mieux réprimer

Chez les eucaryotes, la marque épigénétique H3K27me3 est classiquement associée à la répression transcriptionnelle.

insb.cnrs.fr

The Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination is approaching. There are selected talk slots available. Abstract submission deadline: Tuesday, May 5, 2026.

@sandraduharcourt.bsky.social · 5mo ago

Excited to announce the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination (Sept 21–25, 2026): cjm.sb-roscoff.fr/en/conferenc... Organized by @laurarossevo.bsky.social and myself.

#JobOffer 💼 Ingénieur d’étude H/F en biologie moléculaire 📍Institut Jacques Monod, @mnprioleau.bsky.social Lab 📆 1e juillet 2026 Candidatez sur le portail emploi CNRS avant le 13 mai 2026 🔗 emploi.cnrs.fr/Offres/CDD/U...

now published at BMC Biology! rdcu.be/fdITD

@sandraduharcourt.bsky.social · 9mo ago

Excited to share our new preprint on BioRxiv! A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1... 1/5

#ESR #VeilleESR Tribune de la C3N du #CNRS signée par plus de 700 scientifiques (membres du comité national, directrices et directeurs d'unités) pour alerter une nouvelle fois sur les conséquences des coupes budgétaires c3n-cn.fr/2026/04/10/b...

✍️ The @sandraduharcourt.bsky.social Lab published a new article 📖 Genome Biology 📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium 🔗 link.springer.com/article/10.1...

@sandraduharcourt.bsky.social · 4mo ago

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

Our latest publication is out! @narjournal.bsky.social academic.oup.com/nar/article-...

Transcription at an inducible common fragile site reveals replication origin strength hierarchy

Abstract. While genome-wide analyses in vertebrates suggest that transcription negatively regulates replication origin activation, thereby shaping the land

academic.oup.com

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology

Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

link.springer.com

Our work on chromatin evolution in brown algae is now published in @natecoevo.nature.com! We show that developmentally complex brown algae evolved without epigenetic silencing pathways long thought universal, underscoring why non-model lineages are important to study. www.nature.com/articles/s41...

#JobOffer 💼 Professeur en stabilité du génome 📍Institut Jacques Monod 📆 1e septembre 2026 Les candidatures sont ouvertes jusqu'au 3 avril 2026 16h🔗 u-paris.fr/recrutement-...

I had fun writing this N&Vs on two fascinating new papers on centromere evolution in yeast. If you’re interested in how centromeres adapt yet stay functional, here’s my take. rdcu.be/e6DD0 @nature.com @gautamdey.bsky.social @gsherloc.bsky.social @helsenjana.bsky.social @maxhaase.bsky.social

Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social : www.biorxiv.org/content/10.6...

Excited to announce the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination (Sept 21–25, 2026): cjm.sb-roscoff.fr/en/conferenc... Organized by @laurarossevo.bsky.social and myself.

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...

🚨📢📄 Article in press in Genome Biology doi.org/10.1186/s130... We introduce panREPET, a reference-free pipeline to detect shared transposable element (TE) insertions across pangenomes and retrace their evolutionary dynamics #TEsky 🧵👇

A reference-free pipeline for detecting shared transposable elements from pan-genomes to retrace their dynamics in a species - Genome Biology

Background The role of transposable elements (TEs) in host adaptation has gained interest in recent years. Individuals of the same species undergo independent TE insertions, providing genetic variabil...

doi.org

Pierre Capy était un généticien, un drosophiliste, un acteur majeur dans l'essor de la génétique des éléments transposables en France. Très impliqué dans l'administration de la vie scientifique, il a aussi été directeur du laboratoire LEGS (actuel @EGCE), et un des fondateurs en 2016 de @IDEEV.

We are pleased to share a new preprint on BioRxiv www.biorxiv.org/content/10.6.... @ijmonod.bsky.social.

Ploidy-dependent modulation of DNA replication kinetics in Xenopus

DNA replication in multicellular organisms follows a tightly regulated spatio-temporal program. Although the mechanisms underlying this replication program remain only partially understood, studies in...

biorxiv.org

We are recruting an assistant engineer for 18 months at LBBE (Lyon, France) in molecular biology of Drosophila. The project is to study the interactions between response to viral infections and control of transposable elements. emploi.cnrs.fr/Offres/CDD/U...

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

bioRxivpreprint@biorxivpreprint.bsky.social · 7mo ago

Evolutionary dynamics of temporal transcription factor series in the insect optic lobe https://www.biorxiv.org/content/10.64898/2026.01.08.698497v1

✍️ The @sandraduharcourt.bsky.social Lab published a new article 📖 @natrevmcb.nature.com 📃 Programmed ‘DNA splicing’ removes transposons from genes 🔗 www.nature.com/articles/s41...

Happy to begin the year with the publication of a Journal Club article - Programmed ‘DNA splicing’ removes transposons from genes. rdcu.be/eXBym

Programmed ‘DNA splicing’ removes transposons from genes

Nature Reviews Molecular Cell Biology - A study that showed that programmed DNA elimination in somatic genomes of ciliates involves excision of intrusive, transposon-derived sequences from genes.

rdcu.be

Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social

Open Senior Bioinformatician position at @sangerinstitute.bsky.social Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me. 📅 Apply by January 18 🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco... Please share with anyone who might be interested!

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

Evolutionary cell biology comes of age

Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...

journals.biologists.com