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Nicolas Bierne

@couplingdmi.bsky.social

CNRS researcher at @isemevol.bsky.social Montpellier Population Genetics, Evolution, Marine Biology, Transmissible Cancers #PopGen #Hybridization #Introgression #MarEvol #Transcan #MusselsAreCool

197 Posts1612 Follower1128 Folgt
Nicolas Bierne@couplingdmi.bsky.social · 2d ago

New preprint from the team #AdaptiveIntrogression #Haplotagging #PopGen #MarEvol "Adaptive introgression in subdivided populations leaves distinct genomic footprints under global and local selection: a case study in Ciona intestinalis" www.biorxiv.org/content/10.6...

Adaptive introgression in subdivided populations leaves distinct genomic footprints under global and local selection: a case study in Ciona intestinalis

Adaptive introgression, the transfer of beneficial alleles between species through hybridization, is increasingly recognized as an important source of adaptation to novel environments. However, the th...

biorxiv.org

Pleuni Pennings@pleunipennings.bsky.social · last wk.

I am hiring a postdoc! Are you interested to work on population genetics/ drug resistance/ data? Want to work in Montpellier, France? Fastq files don't scare you? PhD required, start date hopefully Nov 1! (end date Sep 30 2028) Please share! abetterscientist.wordpress.com/2026/09/29/p...

Postdoc position on drug resistance evolution in Montpellier, France

I have some exciting news (again!). I got money from the region (Occitanie) to hire a postdoc (and later an engineer / technician) to work on drug resistance evolution in malaria (P. faciparum) and…

abetterscientist.wordpress.com

Nicolas Bierne@couplingdmi.bsky.social · last mo.

A substantially revised V2 of our work on SNPs associated with rampant polymorphic duplications in the European flat oyster 🦪is out! ~15% of SNPs are associated with polymorphic duplications, with a striking concentration on 3 of the 10 chromosomes. #PopGen #MarEvol www.biorxiv.org/content/10.1...

Allelic coverage analyses reveal a high proportion and uneven chromosomal distribution of SNPs associated with polymorphic duplications in the oyster Ostrea edulis

Marine bivalves are known for their high genetic diversity and potentially high genetic load, as well as their structurally complex genomes. The European flat oyster, Ostrea edulis , is no exception. ...

biorxiv.org

Nicolas Bierne@couplingdmi.bsky.social · last yr.

#PopGen New preprint of the team on the discovery of a very high rate of polymorphic duplication in a marine bivalve. Imagine looking at the distribution of the allelic coverage fraction at heterozygous calls in an indivdual and getting this distribution 👇 😱😱😱

Max Stammnitz@maxstammnitz.bsky.social · 3mo ago

Wow! A fourth class of transmissible cancers. CONTAGIOUS FISH MELANOMA, discovered in Lake Memphremagog (Vermont / Quebec) 🎣 🧬 😷 www.nature.com/articles/s41... @uvmvermont.bsky.social

Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

nature.com

Julien Joseph@jujoseph.bsky.social · 3mo ago

Hi everyone, I just started a bluesky account to share my work and keep up with the work of others :) ! I am very pleased to share this review on the evolutionary causes behind the existence of meiotic recombination hotspots: doi.org/10.1371/jour... I hope it will be useful to some of you!

Why recombination hotspots?

Meiotic recombination is the process by which DNA is exchanged between parental chromosomes during the production of gametes in eukaryotes. This phenomenon has important implications for fertility, ge...

doi.org

Michael Metzger@metzgerm.bsky.social · 3mo ago

I am excited to present our newest report on a severe outbreak of transmissible cancer in clams in the Pacific Northwest, with a lot of unexpected twists. Led by Sydney Weinandt and Zach Child. www.pnas.org/doi/10.1073/pnas.2611852123 1/14

Atlantic to Pacific: Outbreak of bivalve transmissible neoplasia detected in hybridizing soft-shell clams and eDNA in Puget Sound | PNAS

Bivalve transmissible neoplasias (BTNs) are transmissible cancers that have arisen in multiple bivalve species, including Eastern soft-shell clam (...

pnas.org

Molly Przeworski@mollyprz.bsky.social · 5mo ago

Happy to highlight new findings by Vanesa Getseva and Lin Poyraz about the sources of variation in germline mutation rates among humans: www.biorxiv.org/content/10.6... Joint work with Anastasia Stolyarova and @ipsitaagarwal.bsky.social. 1/n

A sibling study of variation in parental mutation rates

People are born with variable numbers of de novo germline mutations (DNMs), depending primarily on the ages of their parents. To explore additional causes, we developed an approach to call DNMs from nucleotide differences between siblings in genomic regions inherited identical by descent from both parents. Applying it to whole genome sequences from 28,985 sibling pairs of diverse genetic ancestries present in the UK Biobank and All of Us datasets, as well as 2,330 trios, we identified >800K autosomal DNMs and characterized mutation phenotypes in 27,645 sets of parents. We found subtle shifts in the mutation spectrum but no differences in total DNM rates among genetic ancestry groups, or between smokers and non-smokers. Testing for associations between parental mutation phenotypes and their burden of loss-of-function and deleterious missense variants in a set of 180 DNA repair and maintenance genes, we discovered that disruptions in REV1 and LIG1 increase germline mutation rates, and thus that rare mutator alleles segregate in population cohorts. ### Competing Interest Statement The authors have declared no competing interest. NIH, R35 GM083098

biorxiv.org

Vincent CASTRIC@vincentcastric.bsky.social · 5mo ago

Ever wondered what makes some alleles dominant (A) and others recessive (a) ? In our new paper, we explored how a series of recently discovered "dominance modifiers", genetic elements that have long remained elusive, achieve their regulatory function. journals.plos.org/plosgenetics...

Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways

Author summary Many plants avoid self-fertilization through a system of self-incompatibility, which allows them to recognize and reject their own pollen. In plants like those in the Arabidopsis family...

journals.plos.org

Gabriele Nocchi@gabnocgenomics.bsky.social · 6mo ago

Happy to share this paper with @samyeaman.bsky.social, now published in Molecular Biology and Evolution! Using replicated hybrid zones, we explored patterns of local adaptation and introgression in spruce and found strong signals even at very fine geographical scales! doi.org/10.1093/molb...

Replicated hybrid zones reveal genomic patterns of local adaptation and introgression in spruce

Abstract. Hybridization between species can occur along repeated zones of contact, providing a natural laboratory for studying the interplay between migrat

doi.org

Rob Noble@robjohnnoble.bsky.social · 7mo ago

Academics often lament that hardly any master’s projects get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I tell how one master’s project was, through persistent teamwork, finally carried over the finish line: go.nature.com/4aKs7N3

On the expansion and evolution of a master’s project

Academics often lament that hardly any master’s projects – even the best ones – get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I tel...

go.nature.com

Nicolas Bierne@couplingdmi.bsky.social · 7mo ago

April Fools’ Day is coming early this year, but really, any day is a good day to poke fun at the system. Well done @russcd.bsky.social

Molecular Biology and Evolution@molbioevol.bsky.social · 7mo ago

@russcd.bsky.social ushers in a new era of academic metrics with the core-pivotal author index, which assigns all credit to authors that occupy the exact center of the author list, while non-central peripheral authors receive no credit whatsoever. 🔗 doi.org/10.1093/molbev/msag026 #evobio #molbio

@cfraisserios.bsky.social · 7mo ago

We are offering a fully funded two-year postdoctoral position focused on sex chromosome evolution and speciation in the *Jaera albifrons* species complex. Please find the advertisement attached. We welcome applications from interested candidates. Join us :-)

Maren Wellenreuther@marenwellenreuther.bsky.social · 7mo ago

New out: A Beginner’s Guide to Structural Variants in Eco-Evolutionary Population Genomics. We outline how to detect and analyse SVs, discuss key challenges, and provide a practical framework for population-level studies A resource for students entering SV research. doi.org/10.1111/mec....

A Beginner's Guide to Structural Variants in Eco‐Evolutionary Population Genomics

Whole-genome sequencing (WGS) has greatly expanded researchers' ability to study structural variants (SVs), that is, the variation in the presence, number, orientation or position of a DNA sequence. ....

doi.org

Aline Muyle@aline-muyle.bsky.social · 7mo ago

I am hiring a Postdoc (18 months contract in Montpellier, France) to study how polyploidy affects sex chromosomes in the plant Silene latifolia, using bioinformatic analyses of RNA-seq and DNA-seq data. Deadline for applications March 24th. euraxess.ec.europa.eu/jobs/412961

Post doc position in Evolutionary biology and bioinformatics

- work environment: This postdoctoral position will be supervised by Aline Muyle and hosted at the Institute of Evolutionary Sciences of Montpellier (ISEM), within the CHANGE department and the Plant ...

euraxess.ec.europa.eu

Nicolas Bierne@couplingdmi.bsky.social · 7mo ago

A huge thank you to Iva and Cynthia @seaprof.bsky.social and the all Riginos lab for inviting me to make a modest contribution to this study. My first coral paper 🌊🪸 🎉 A dream come true 😊. I really encourage you to read it #MustRead Two major take-home messages for hybridization genomics 👇

Cynthia Riginos@seaprof.bsky.social · 8mo ago

Led by Iva Popovic, with Katharine Prata, @melissanaugle.bsky.social le.bsky.social, @ilhabyrne.bsky.social habyrne.bsky.social, Sam Howitt, Tom Bridge, Vero Mocellin, Emily Howells, Line Bay & @couplingdmi.bsky.social lingdmi.bsky.social #RRAP #AIMS @uq-cbcs.bsky.social

Cynthia Riginos@seaprof.bsky.social · 8mo ago

Led by Iva Popovic, with Katharine Prata, @melissanaugle.bsky.social le.bsky.social, @ilhabyrne.bsky.social habyrne.bsky.social, Sam Howitt, Tom Bridge, Vero Mocellin, Emily Howells, Line Bay & @couplingdmi.bsky.social lingdmi.bsky.social #RRAP #AIMS @uq-cbcs.bsky.social

Bluesky

habyrne.bsky.social

Cynthia Riginos@seaprof.bsky.social · 8mo ago

Three-way hybridization of table corals in the Acropora hyacinthus group from the southern Great Barrier Reef results in parallel adaptive introgression. Check out our new preprint: doi.org/10.64898/202... #CoralSky #MarEvol #coral #popgen #consgen #genomics

Table coral