Corcoran Lab
@corcoranlab.bsky.social
she/her Molecular virologist and Associate professor at the University of Calgary, Canada.
Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression: Molecular Cell www.cell.com/molecular-ce...
Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression
Kaposin is an abundant viral RNA produced by the virus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Kleer et al. reveal that kaposin drives nuclear speckle formation adjacent to the viral genome, ...
cell.com
So happy to have this story out! What started as a project about the protein products of a polycistronic mRNA ended up becoming a story about how RNA-mediated assembly of nuclear speckles promotes viral gene expression. What a ride, some very good days on the microscope!! 🔬 @corcoranlab.bsky.social
Molecular Cell@cp-molcell.bsky.social · last mo.Online Now: Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression Online now:
Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression: Molecular Cell www.cell.com/molecular-ce...
Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression
Kaposin is an abundant viral RNA produced by the virus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Kleer et al. reveal that kaposin drives nuclear speckle formation adjacent to the viral genome, ...
cell.com
Our study of coronavirus structural proteins that interfere with host responses to infection, led by Drs. Taylor Caddell and Eric Pringle, with support from colleagues @rorymulloy.bksy.social and @corcoranlab.bsky.social, is now published in @PLOSPathogens journals.plos.org/plospathogen... (1/8)
Coronavirus M protein disperses the trans-Golgi network and inhibits anterograde protein trafficking in the secretory pathway
Author summary Coronaviruses (CoVs) use the endoplasmic reticulum (ER) for synthesis and processing of viral transmembrane proteins, including those that sculpt ER membranes into replication compartme...
journals.plos.org
Do you like microscopy? Do you think viruses are cool? Do you want to advance our understanding of one of the world's most important pathogens? Come and do your PhD with myself and the fantastic @peacockflu.bsky.social, at @pirbrightinst.bsky.social and @cvrinfo.bsky.social 🤓🦠🐓
FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com
findaphd.com
#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr
Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social Details in the thread below - please share! Deadline 8th May 2026, fully funded for UK Home students (1/4)
So proud to have worked alongside @rorymulloy.bsky.social and @corcoranlab.bsky.social on this amazing project, now out in @plosbiology.org! journals.plos.org/plosbiology/...
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
journals.plos.org
#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr
journals.plos.org/plosbiology/...
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
journals.plos.org
New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.
bit.ly
This is an incredibly moving thread.
Jeremy Berg@jeremymberg.bsky.social · 2y agoBluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of: doi.org/10.1101/2025... Bluetorial follows 🟦🧵
Protein-based tools for the detection and characterisation of Oropouche virus infection
Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...
doi.org
@rorymulloy.bsky.social et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans 👀. From: @corcoranlab.bsky.social www.biorxiv.org/content/10.1...
A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
biorxiv.org
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran www.biorxiv.org/content/10.1...
Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...
A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
biorxiv.org