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Noga Sharlin

@nogasharlin.bsky.social

PhD student at the University of Calgary Studying human coronaviruses and innate immune responses in the Corcoran Lab

2 Posts57 Follower104 Folgt
Noga Sharlin@nogasharlin.bsky.social · 3w ago

Excited to have this preprint out showing that N proteins of human coronaviruses differ in their ability to inhibit antiviral responses! Many thanks to my supervisor Jennifer Corcoran @corcoranlab.bsky.social, as well as to co-authors @rorymulloy.bsky.social and Madeline Day for all their support!

Human coronavirus nucleocapsid proteins have disparate innate immune evasion abilities

During infection, coronaviruses produce abundant double-stranded RNA (dsRNA) which can induce antiviral innate immune responses such as the interferon, 2'-5'-oligoadenylate synthetase (OAS)/RNase L, a...

biorxiv.org

Fletcher Lab@fletcherlab.bsky.social · 2mo ago

Delighted to share our article on the functional expansion of OAS2 via alt. splicing. link.springer.com/article/10.1... A tour de force from PhD student Emma Davies and friends.

Alternative splicing broadens antiviral diversity at the human OAS2 locus - The EMBO Journal

Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provi...

link.springer.com

Craig McCormick@craigmccormick.bsky.social · 3mo ago

Our study of coronavirus structural proteins that interfere with host responses to infection, led by Drs. Taylor Caddell and Eric Pringle, with support from colleagues @rorymulloy.bksy.social and @corcoranlab.bsky.social, is now published in @PLOSPathogens journals.plos.org/plospathogen... (1/8)

Coronavirus M protein disperses the trans-Golgi network and inhibits anterograde protein trafficking in the secretory pathway

Author summary Coronaviruses (CoVs) use the endoplasmic reticulum (ER) for synthesis and processing of viral transmembrane proteins, including those that sculpt ER membranes into replication compartme...

journals.plos.org

Arinjay Banerjee@banerjeelab.ca · 4mo ago

🚨 New publication 🚨 Our collaboration with the Overall lab at UBC has yielded new insights from our latest study on SARS-CoV-2 and its impact on the human immune system. Incredible work by all the trainees. #LoveVirology www.cell.com/cell-reports... @cp-cellreports.bsky.social (1/3)

Non-canonical proteolytic activation of RNase L by SARS-CoV-2 3CLpro offsets inactivation of OAS1 p46 antiviral signaling

Bell et al. demonstrate that SARS-CoV-2 3C-like main protease (3CLpro/Mpro) antagonizes the OAS-RNase L antiviral pathway by cleaving off the prenylated-Cys397 anchor from OAS1 p46, displacing it from...

cell.com

Rory Mulloy@rorymulloy.bsky.social · 4mo ago

SUPER COOL to have my recent paper highlighted by CoV transcription legends, Drs Isabel Sola & Sonia Zuñiga in a PLoS Bio Primer. A much better read than the AI summary of the paper 💥 journals.plos.org/plosbiology/...

New transcription signals in SARS-CoV-2 reshape virus–host interactions

Non-spike changes driving SARS-CoV-2 fitness remain undiscovered. This Primer comments on two PLOS Biology papers that show that evolutionary N gene mutations create a transcription-regulating sequenc...

journals.plos.org

Rory Mulloy@rorymulloy.bsky.social · 4mo ago

💥 Paper published 💥 Curious how #SARS2 has changed since jumping into humans? We were too! journals.plos.org/plosbiology/... 🧵 🧵 🧵

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses

SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

journals.plos.org

Noga Sharlin@nogasharlin.bsky.social · 4mo ago

So proud to have worked alongside @rorymulloy.bsky.social and @corcoranlab.bsky.social on this amazing project, now out in @plosbiology.org! journals.plos.org/plosbiology/...

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses

SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

journals.plos.org

Karim Majzoub@karimaj.bsky.social · 5mo ago

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

Deltaviruses spread through a viral Trojan Horse

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

sciencedirect.com

Nature Microbiology@natmicrobiol.nature.com · 10mo ago

The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition By Dustin Glasner, Matthew Daugherty & colleagues. #microsky www.nature.com/articles/s41...

The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition - Nature Microbiology

Viruses generally have compact genomes, resulting in many viral mRNAs with short 5’ untranslated regions. An antiviral complex exploits this feature of viral mRNAs to selectively inhibit viral protein...

nature.com

Emily Bruce@brucelab.bsky.social · last yr.

Very happy that this story is now published in @plosbiology.org. It includes lots of additional data, (creation of the G215S mutant) & demonstrates the increased growth/ oligomerization of N is specific to the cysteine at 215. Thanks to the coauthors, reviewers and editors who helped improve it!

Emily Bruce@brucelab.bsky.social · 2y ago

1/n Very excited to share my lab's latest manuscript, 3 years after I started my independent group! This was a fantastic collaboration with Bryan Johnson and @themenacherylab.bsky.social , led by joint 1st authors Hannah Kubinski and Hannah Despres in my lab www.biorxiv.org/content/10.1...

Chris Sullivan@sullivanlab.bsky.social · last yr.

Previously, KO and overexpression showed host RNA 5’ triphosphatase DUSP11 can reduce RIG-I sensitivity. Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral. journals.plos.org/plospathogen...

Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

journals.plos.org

Corcoran Lab@corcoranlab.bsky.social · last yr.

Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses

Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...

biorxiv.org