ICYMI: Living in the age of inflammation: the reverse hygiene hypothesis

Living in the age of inflammation: the reverse hygiene hypothesis

Nature Reviews Immunology, Published online: 19 August 2026; doi:10.1038/s41577-026-01349-4Inflammation seems to permeate many aspects of our lives, with the incidence of inflammatory diseases on the rise and ageing being blamed on it. Will the next 25 years see better ways to treat or prevent inflammation and allow us to live longer and healthier lives?

dlvr.it

Congratulations to Dr. Angus Thomson for being a guest on the @mayoclinic.org “Tomorrow’s Cure” podcast! The audio episode can be found wherever you get podcasts (Apple, Spotify, etc). The video version is available on YouTube (www.youtube.com/watch?v=ATaO...). Congrats, Dr. Thomson!

Know a college sophomore/junior in Pittsburgh who's interested in their first research opportunity? The Microbiology & Immunology Depts. Scholars program is for them! 4 semesters of hands-on research, mentorship & more. Apply by Sept. 2: www.pmi.pitt.edu/research/mid... @pitt-pmi.bsky.social

Online now: CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

Dendritic cells (DCs) can acquire distinct functional states. To examine how different DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to label and ablate CCR7+ DCs and find that this activation state is essential for tumor control by uniquely priming tumor-specific cytotoxic T lymphocytes (CTLs), sustaining their function and enabling responses to immunotherapy.

dlvr.it

Congratulations to Dr Okereke! Here she presents our work showing the accumulation of granzyme k+ cd8 T cells in the lungs and lung draining lymph nodes of patients with end stage IPF. www.mucosalimmunology.org/article/S193...

Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options...

mucosalimmunology.org

⏰ Time is running out! Travel grant applications for the 2026 Fellows Symposium on Transplantation are open—but only through July 31. Don't miss this opportunity to gain valuable education, connect with transplant leaders, and grow your professional network. Apply today: myAST.org/Fellows

Congratulations to Jordan Warunek from the @hector15215.bsky.social laboratory on his upcoming thesis defense! 🎈👏

Our JUNE ISSUE is live! Therapeutic targets for MASH, metabotherapy for intestinal disease, germiline mutations and somatic mosaicism in SLD-related liver cancer, artificial intelligence in IBD, and much more! www.nature.com/nrgastro/vol...

Have questions about FSGS? Learn more about symptoms, tests, and treatments for this kidney disease: bit.ly/4eZ959t

TODAY‼️Be there or be square🤓

Thomas E. Starzl Transplantation Institute@starzlinstitute.bsky.social · 4mo ago

Join us next Wednesday to hear Dr. Jan Lerut present "The Art of Immune Suppression in Liver Transplantation - 40 Years of Personal Experience" for the 2026 Thomas E. Starzl Prize in Surgery & Immunology! 📅 May 20, 2026 🕐 4pm 📍 Scaife Hall, Auditorium 3785 & Zoom

A new #ScienceImmunology study shows that anti–PD-1 antibodies trap PD1 at nanoscale immune contacts and induce inhibitory checkpoint signaling, highlighting avenues for optimizing future immunotherapies. https://scim.ag/3R7WNBL

PD-1 signaling and PD-1 blockade–mediated tumor control are established at microvillar T cell contacts

Microvillar contacts serve as sites of TCR and PD-1 signal integration, modulating T cell activation and tumor control.

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Congratulations to Sridula Kallakuri for being awarded a #COTS #ATC Travel Grant as well as was a runner-up for her oral presentation at the Dept of #Surgery Annual Research Day and Richard L. Simmons Lecture in Surgical #Science. Congrats!🥳👏

Join us next Wednesday to hear Dr. Jan Lerut present "The Art of Immune Suppression in Liver Transplantation - 40 Years of Personal Experience" for the 2026 Thomas E. Starzl Prize in Surgery & Immunology! 📅 May 20, 2026 🕐 4pm 📍 Scaife Hall, Auditorium 3785 & Zoom

The May 2026 issue of #ScienceImmunology is out! This month's cover depicts a cytotoxic T cell filled with citraconate molecules, which can enhance antitumor responses and protect against exhaustion. Learn about this research and more: https://scim.ag/48wtaQq

STI is proud to announce that the 2026 Stuart K. Patrick #Grant for #Transplant #Innovation awardee is Dr. Aravind Cherukuri for "Mapping Resistance: Spatial Dissection of Tissue-Resident Memory T Cells in Refractory TCMR"! Congratulations to you & best wishes for a successful research term!!🎉

Today is AMKD Awareness Day. Did you know that genetic testing is the only way to find out if you have APOL1 risk variants linked with a higher risk for AMKD? Learn more about the risks and if genetic testing is right for you: bit.ly/4v0k8Vo

Huge thank you to @miriammerad.bsky.social for presenting "Macrophages: Key Guardians of Tissue Health and Drivers of Diseases" last week at our first 2026 #Eberly Distinguished Lectureship in #Immunology!! It was an honor to host you and hear your lecture!🌟🔬

Congratulations to Drs. Abhinav Humar, Angus Thomson, et al!!! They recently published an article in Nature Communications: www.nature.com/articles/s41... Meet Barb and learn more about this treatment here: wdrv.it/4a0a44b7d. Congratulations to all!!!

Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial - Nature Communications

Reducing or stopping immunosuppression in recipients of allografts has the potential to spare them from increased risk of infection, malignancy and cardiovascular events. Here, the authors report the ...

nature.com

Join us and @starzlinstitute.bsky.social on Thursday to hear @miriammerad.bsky.social present "Macrophages Key Guardians of Tissue Health and Drivers of Diseases" for the the Eberly Distinguished Lectureship in Immunology! 📅 April 23, 2026 🕐 1pm 📍 The Assembly Auditorium & Zoom

Scientists uncover pre-treatment signatures in monocytes, myeloid cells, and T cells that predict corticosteroid resistance in patients with acute GVHD, hinting steroid resistance is an intrinsic property of immune cells. #ScienceTranslationalMedicine https://scim.ag/4t6Y4ar

Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

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Dr. Miriam Merad (Icahn School of Medicine at Mt Sinai) will present "Macrophages Key Guardians of Tissue Health and Drivers of Diseases" at our next #Eberly Distinguished Lectureship in #Immunology! @pitt-pmi.bsky.social See you Thurs., April 23rd at noon in the Assembly Auditorium or Zoom!

New Review on "Renaissance of antiviral CD8+ T cell immunity in vaccination and disease" by Victor Appay, Takuya Yamamoto & Asier Sáez-Cirión. www.nature.com/articles/s41...

Renaissance of antiviral CD8+ T cell immunity in vaccination and disease - Nature Reviews Immunology

Past failures of T cell-based vaccines for chronic viral infection may reflect suboptimal induction of quality T cell responses. Here, the authors highlight the need to integrate diverse functional at...

nature.com

📢 Attention Medical Students & Residents! Applications are open for the AST Medical Student and Resident ATC 2026 Travel Grant. ➡️ Apply before March 30, 2026: www.myast.org/ast-medical-...

AST Medical Student and Resident ATC 2026 Travel Grant

Make a difference in the field of transplantation by donating to support our cause.

myast.org

The March 2026 issue of #ScienceImmunology is out! This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them. Learn about this research and more: https://scim.ag/4rL6F1I

In our March issue www.nature.com/nri/volumes/... Find out about: 🚀Astroimmunology 🎯Targeting organelles in cancer immunotherapy 🧠Immunotherapy for CNS tumours 🪨How the TME contributes to CAR T cell resistance

Ramadan is the ninth and holiest month of the Islamic calendar, observed by Muslims around the world as 30-day period of fasting, prayer and reflection. Community resources, including dining options for those who are fasting, are available on our website: www.wellbeing.pitt.edu/news/ramadan...

"Association Between Three Lung Donor Scores and Lung Acceptance in DBD and DCD Donors" Read more here: shorturl.at/D8c5z #lung #transplant #DBD #DCD #donor #score #acceptance @esottransplant.bsky.social

REMINDER that these applications are due Monday night (16th)!! Visit our website for details and materials: stiresearch.health.pitt.edu/funding-oppo...

Thomas E. Starzl Transplantation Institute@starzlinstitute.bsky.social · 9mo ago

STI is thrilled to announce that #applications for our Stuart K. Patrick Grant for #Transplant #Innovation are now OPEN!🔬🦠 The submission deadline is February 16, 2026, with a July 1st award activation. Visit our website for details and materials: stiresearch.health.pitt.edu/funding-oppo...

Your abstract ghosted us … so we gave it more time 💘 The deadline for abstract submissions has been extended to Monday, February 16, at 11:59 p.m.! Groundbreaking research, just like true love, shouldn't be rushed.🔬❤️ 🔗https://dom.pitt.edu/research-day/ #DOMResearchDay #ResearchMatters