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Thomas E. Starzl Transplantation Institute

@starzlinstitute.bsky.social

Our mission has been to improve the clinical, scientific, and social aspects of transplantation. Associated with the University of Pittsburgh and UPMC.

33 Posts39 Follower44 Folgt
Immunity@cp-immunity.bsky.social · 2d ago

Online now: CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

Dendritic cells (DCs) can acquire distinct functional states. To examine how different DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to label and ablate CCR7+ DCs and find that this activation state is essential for tumor control by uniquely priming tumor-specific cytotoxic T lymphocytes (CTLs), sustaining their function and enabling responses to immunotherapy.

dlvr.it

@markesnyder.bsky.social · last wk.

Congratulations to Dr Okereke! Here she presents our work showing the accumulation of granzyme k+ cd8 T cells in the lungs and lung draining lymph nodes of patients with end stage IPF. www.mucosalimmunology.org/article/S193...

Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options...

mucosalimmunology.org

Science Magazine@science.org · 3mo ago

A new #ScienceImmunology study shows that anti–PD-1 antibodies trap PD1 at nanoscale immune contacts and induce inhibitory checkpoint signaling, highlighting avenues for optimizing future immunotherapies. https://scim.ag/3R7WNBL

PD-1 signaling and PD-1 blockade–mediated tumor control are established at microvillar T cell contacts

Microvillar contacts serve as sites of TCR and PD-1 signal integration, modulating T cell activation and tumor control.

scim.ag

Thomas E. Starzl Transplantation Institute@starzlinstitute.bsky.social · 4mo ago

Congratulations to Drs. Abhinav Humar, Angus Thomson, et al!!! They recently published an article in Nature Communications: www.nature.com/articles/s41... Meet Barb and learn more about this treatment here: wdrv.it/4a0a44b7d. Congratulations to all!!!

Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial - Nature Communications

Reducing or stopping immunosuppression in recipients of allografts has the potential to spare them from increased risk of infection, malignancy and cardiovascular events. Here, the authors report the ...

nature.com

Science Magazine@science.org · 4mo ago

Scientists uncover pre-treatment signatures in monocytes, myeloid cells, and T cells that predict corticosteroid resistance in patients with acute GVHD, hinting steroid resistance is an intrinsic property of immune cells. #ScienceTranslationalMedicine https://scim.ag/4t6Y4ar

Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

scim.ag

Nature Reviews Immunology@natrevimmunol.nature.com · 4mo ago

New Review on "Renaissance of antiviral CD8+ T cell immunity in vaccination and disease" by Victor Appay, Takuya Yamamoto & Asier Sáez-Cirión. www.nature.com/articles/s41...

Renaissance of antiviral CD8+ T cell immunity in vaccination and disease - Nature Reviews Immunology

Past failures of T cell-based vaccines for chronic viral infection may reflect suboptimal induction of quality T cell responses. Here, the authors highlight the need to integrate diverse functional at...

nature.com

Pitt Office of Institutional Engagement & Wellbeing@pittwellbeing.bsky.social · 6mo ago

Ramadan is the ninth and holiest month of the Islamic calendar, observed by Muslims around the world as 30-day period of fasting, prayer and reflection. Community resources, including dining options for those who are fasting, are available on our website: www.wellbeing.pitt.edu/news/ramadan...

Ramadan resources for 2026 | Office of Institutional Engagement and Wellbeing

Ramadan begins at sunset Feb. 17 and continues until Eid al-Fitr on March 19. This is the ninth and holiest month of the Islamic calendar, observed by Muslims around the world as 30-day period of fast...

wellbeing.pitt.edu

Thomas E. Starzl Transplantation Institute@starzlinstitute.bsky.social · 6mo ago

REMINDER that these applications are due Monday night (16th)!! Visit our website for details and materials: stiresearch.health.pitt.edu/funding-oppo...

Thomas E. Starzl Transplantation Institute@starzlinstitute.bsky.social · 8mo ago

STI is thrilled to announce that #applications for our Stuart K. Patrick Grant for #Transplant #Innovation are now OPEN!🔬🦠 The submission deadline is February 16, 2026, with a July 1st award activation. Visit our website for details and materials: stiresearch.health.pitt.edu/funding-oppo...