Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).

New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)! We're looking for someone keen on bioinformatics and microbiome evolution. Important info below on eligibility & URSA competition funding👇 www.findaphd.com/phds/project...

The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com

PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com

findaphd.com

Well done @eliasallara.bsky.social! Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data. www.thelancet.com/journals/lan...

Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data

Our study offers new insights into recent cardiovascular disease patterns and reveals important health inequalities at a whole-population scale for multiple cardiovascular diseases, during and after t...

thelancet.com

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…

medrxiv.org

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791... You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

Wish we could've cited this highly relevant (and consistent) study, published nearly the same time: Psychological & emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: Findings from PERSPECTIVE I&I www.sciencedirect.com/science/arti...

The concept of personalised health is at the centre of a renewed NHS and its 10 Year Health Plan says Prof Mike Inouye (thank you @mikeinouye.bsky.social)as we put 'Making personalised health work for population health' in the spotlight. Read it here: lnkd.in/eRDY5q2j #personalisedhealth

Variation and prognostic potential of the gut antibiotic resistome in a population-based cohort www.nature.com/articles/s41... We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score www.ahajournals.org/doi/10.1161/...

📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @commsmed.nature.com. We benchmarked a set of PGS for cardiovascular traits available from the pgscatalog.org resource in different Canadian cohorts🍁. See more 👇🏽 - Link (OA): www.nature.com/articles/s43... (1/4)

Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions - Communications Medicine

Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at coronary angiography. The co...

nature.com

Super excited to see beginning integration of PredictDB into OmicsPred! We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org More on its way... a wonderful collab with @hakyim.bsky.social & co!

📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co! Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1... The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!

Its been an absolute pleasure to have @gmeric.bsky.social in the lab for the last 7 years (omg has it been that long) Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!

Guillaume Méric@gmeric.bsky.social · last yr.

Looks like I’ve got another move across the world in me! 🌏✈️📦 I'll be starting at @uniofbath.bsky.social in a few weeks as senior lecturer/associate prof in human microbiome. Excited to be back in Europe + for new collabs (alongside ongoing 🇦🇺🇬🇧🇫🇮🇸🇪🇦🇹 ones). Thanks to everyone who helped; more soon!

@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41... Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms tl;dr 👉 There's little/no evidence for this

📣 Interested in the environmental (un)sustainability of AI (and how to support positive change)? Or know someone who is? I have an open position for a postdoctoral researcher to join my group in Cambridge, UK 🌱 🚨Closing June 5th www.jobs.cam.ac.uk/job/51255/ Topics below 👇 #AcademicSky #GreenSky

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...

📣 Feeling extremely lucky to have modestly contributed to this masterpiece, investigating the impact of loss-of-function mutations in APOC3 gene on aortic valve disease risk reduction. See more in JACC 👇🏽 www.jacc.org/doi/10.1016/...

Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease:

Discover why JACC is the ultimate publishing partner for your cardiovascular research.

jacc.org

📣 Thrilled to share this paper. We leveraged transcriptomic data from one of the largest existing aortic valve collection. We identified genes/pathways involved in disease progression/severity, with distinct transcriptomic signatures in TAV vs BAV. Perspectives for potential therapeutics? See more👇🏽

Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves

There is currently no medical therapy for calcific aortic valve stenosis. We aimed to identify transcriptomic signatures of the disease severity. We p…

sciencedirect.com

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

Can testify to this -> awesome research environment, with access to great ressources, sharing space and time with incredible colleagues and renowned experts...

Mike Inouye@mikeinouye.bsky.social · last yr.

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org ! www.embopress.org/doi/full/10.... A short thread on our key findings 🧵👇

Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease | Molecular Systems Biology

imageimageUsing genetically predicted metabolic reaction fluxes, the authors identify reactions that can amplify or buffer the effect of coronary artery disease (CAD) risk alleles on disease susceptib...

embopress.org

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

Pleased to have been able to make a modest contribution to this piece about the genetic contributors to and consequences of socioeconomic status, initiated and led by @dr-appie.bsky.social . Share with your social science friends!

Abdel Abdellaoui@dr-appie.bsky.social · last yr.

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

Our paper on ancient human population structure is now published. We find that the ancestors of modern humans lived in multiple populations during the period when Homo sapiens evolved in Africa. www.nature.com/articles/s41...

A structured coalescent model reveals deep ancestral structure shared by all modern humans - Nature Genetics

The cobraa model extends the pairwise sequentially Markovian coalescent to identify structured population history by examination of the model transition matrix. Applied to human polymorphism data, cob...

nature.com

Watching the US take a wrecking ball to science 💔 🤯 Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential. www.nature.com/articles/s41...

📣 More data on the impact of high Lp(a) levels on Aortic Valve Disease/CAVS! Patients are more likely to undergo AV replacement during their life course, and face a higher risk of combined CV events. Link (Open Access)👇🏽: www.ahajournals.org/doi/10.1161/...

Impact of Lipoprotein(a) on Valvular and Cardiovascular Outcomes in Patients With Calcific Aortic Valve Stenosis | Journal of the American Heart Association

ahajournals.org

I passed my PhD viva! 🎉 Thank you to everyone who has been a part of this incredible journey, especially my supervisors @iamslambert.bsky.social, Angela Wood, and @mikeinouye.bsky.social 😄

📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41... Check out the INTERVAL RNAseq portal www.intervalrna.org.uk Led by @alextokolyi.bsky.social & Elodie Persyn!