🔬🧫🧬 How does gVasc use your samples and data for SCAD research? Swipe to see more information, key questions, and future directions ➡️ #SCAD #hearthealth #heartresearch #scadalliance #genetics #scadgenetics #womenshealth @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social

What is spontaneous coronary artery dissection (SCAD)? ♥️💬 Watch as Drs. Mark Lindsay, Tiffany Bellomo, and Pradeep Natarajan share information about this condition. gvascstudy.org #SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

How do you join the gVasc Research Study? Visit gvascstudy.org 💻 and follow these easy steps! Complete a few short surveys about your health and receive the saliva kit in the mail 📝 📦 ❤️ #scad #heartresearch #scadalliance @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social

In the Summer we usually slow down… 🏖️ but here are some Fast Facts ⏱️🗒️ about spontaneous coronary artery dissection (SCAD). Visit gvascstudy.org to learn more about the gVasc study today🫀 #SCAD #heartresearch #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

Meet the Team! 🩺 gVasc investigators have extensive experience in cardiovascular disease and genetics🫀🧬 They bring together their expertise to uncover the genetic underpinnings of SCAD 🔍 gvascstudy.org #SCAD #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

gVasc is a research study trying to find out if there are genetic factors behind why SCAD happens🫀Click the link in our bio or head to gvascstudy.org to learn more about our study and to participate! #gvasc #SCAD #research #heart #hearthealth #heartresearch #scadalliance @scadalliance.bsky.social

🗓️ At #CSANZ2025? JAMA Associate Editors @rohankhera.bsky.social‬, MD, MS and @pnatarajanmd.bsky.social, MD, MMSc, will be at Plaza 4 today, Saturday, August 16 from 3 PM to 3:30 PM. ➡️ Stop by to ask questions ➡️ Learn about publishing opportunities @cardiacsociety.bsky.social

Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @broadinstitute.org @mgbresearch.bsky.social

New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com My comments in @nytimes.com nytimes.com/2025/07/21/h...

Polygenic prediction of body mass index and obesity through the life course and across ancestries - Nature Medicine

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to a...

nature.com

Should I tell anyone that I suspect misconduct in a paper I’m reviewing? So important and with more ECRs reviewing this guidance is very welcome. Things to keep in mind: - Extend the benefit of the doubt - Talk to the editor - Check your tone - Balance your responsibilities and your limits

Nature@nature.com · last yr.

Agony aunt 🖋️ A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take? go.nature.com/3UhImt0

Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social

An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...

Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in @CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !! Are genetic and contemporary risk factors as powerful as traditional RFs? #CardioSky #cvPrev

Pradeep Natarajan@pnatarajanmd.bsky.social · last yr.

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score www.ahajournals.org/doi/10.1161/...

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score www.ahajournals.org/doi/10.1161/...

Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!

Pradeep Natarajan@pnatarajanmd.bsky.social · last yr.

Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio

Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social

Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41... Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms tl;dr 👉 There's little/no evidence for this

Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy. Register us02web.zoom.us/meeting/regi... @drmarthagulati.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social .

Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025

A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...

The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS... @mgbresearch.bsky.social @harvardmed.bsky.social

MPG Primer: A Practical Primer on Bayesian Statistics (2025)

YouTube video by Broad Institute

youtube.com

End of an era icelandmonitor.mbl.is/news/news/20...

Kári Stefánsson steps down as CEO of DeCode Genetics

Kári Stefánsson, founder and long-time CEO of DeCode Genetics, has officially stepped down from his leadership role at the company he established nearly three decades ago. The announcement marks the e...

icelandmonitor.mbl.is

Great paper on the intrinsic link between LDL and diabetes risk from @pnatarajanmd.bsky.social @skoyama.bsky.social @somijemmacho.bsky.social and colleagues: jamanetwork.com/journals/jam...

Genetic Predisposition to LDL-C and Incident Type 2 Diabetes

This cohort study uses whole-exome sequencing, genome-wide genotyping, baseline lipid levels, and incident events to assess the association of genetic predisposition to low-density lipoprotein cholest...

jamanetwork.com

Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!

The American Journal of Human Genetics@ajhgnews.bsky.social · last yr.

📣New from @hilarycmartin.bsky.social & co! 📄Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity

The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social Please sign up and share! ourhealthstudy.org @romitb.bsky.social

Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv

Had a great time working on this project - so thrilled to see this work finally out now!!

Pradeep Natarajan@pnatarajanmd.bsky.social · last yr.

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...

Study finds that Non-DNMT3A CHIP was associated with CKD progression among individuals with CKD, and Tet2-CHIP mouse models support a causal role in kidney injury. https://bit.ly/JASN0680 @drflashheart.bsky.social @pnatarajanmd.bsky.social @zhiyu.bsky.social #ASNJASN