Mark Mandel

@markjmandel.bsky.social

Bacterial geneticist focused on microbe-animal communication. Professor UW-Madison. Messages are my personal views.

🎙️ JOB: OPEN RANK PROFESSOR in MUCOSAL IMMUNOLOGY. Seeking faculty candidates focused on immune cell development, function at mucosal surfaces, and cellular metabolism, including interactions with the microbiome, etc. Come one, come call to the jubilee! psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...

Assistant/Associate/Professor of Mucosal Immunology

APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...

psu.wd1.myworkdayjobs.com

Postdoc opening in my lab! Looking for someone excited about genomes, symbionts and plant–insect interactions to join our team at @thesainsburylab.bsky.social. 🧬🍄🌿🦟 Applications reviewed from 16 Nov. buff.ly/WZtMcGs

Postdoctoral Researcher

buff.ly

The Sainsbury Laboratory@thesainsburylab.bsky.social · 5d ago

VACANCY: Postdoctoral Researcher in the Berasategui Lab at TSL, Norwich, UK @berasymbionts.bsky.social Work at the interface of evolutionary genomics, plant pathology and insect symbiosis, within a world-class research environment. Application review starts 16 Nov 2026 buff.ly/WZtMcGs

We found that the most gendered experience wasn’t work-life balance, the focus of most retention efforts. It was feeling devalued, in formal evaluations, but particularly in everyday interactions. Unlike every other topic, the gender gap in devaluation was larger among more senior faculty.

Excited to share a new minireview from my lab led by @anyawoj.bsky.social and Melissa Shinfuku. We highlight how multiple variants of a single bacterial species can coexist in the human body and how this impacts human health. journals.asm.org/doi/10.1128/... #Microsky #Microbiome #Microdiversity

No strain, no gain: within-host bacterial microdiversity and human health | Infection and Immunity

The bacterial world is teeming with diversity, from cyanobacteria to episymbiotic Saccharibacteria to the well-studied Escherichia coli. However, even within a single species, organisms vary in their gene content and gene sequences, leading to significant functional differences across very closely related bacteria. For instance, two isolates of E. coli may share only 40% of the same gene content, allowing different strains to function as human pathogens, gut mutualists, or environmental specialists (1–4). Although this population-level diversity in bacteria has been long-recognized, recent studies have increasingly emphasized that a single person can harbor multiple genotypes of a species at the same time within a single body site. High within-host intra-species diversity can occur in the human microbiota, including in the gut, skin, oral cavity, and vagina. Furthermore, although acute infections are primarily monoclonal, chronic infections can often be polyclonal. Both in the microbiota and in chronic infections, this high intra-species diversity can occur when multiple strains colonize a site over time and when bacteria diversify through evolutionary processes.

journals.asm.org

I have a pair of terrace level tickets to Game 1 of the NLDS in Milwaukee this Saturday Unfortunately, it seems hockey will be getting in the way of those plans. If anyone has Game 2 tickets and is interested in trading games so you can see the Miz start Game 1, please hit my DMs!

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

I enjoyed reading this as it reminded me that when used correctly genetics can tell us so much about biological processes. I worry that our trainees are not learning this as we focus on teaching the latest and greatest. Hopefully Tom's article will remind everyone about the power of genetics