James Kragel

@jkragel.bsky.social

Research assistant professor at UChicago studying the neural basis of episodic memory.

Many have heard the expression “All models are wrong but some models are useful”. I prefer its counter-positive: “All models are wrong and most models are useless”, which I think more closely captures a lot of science.

🚨🚨 Job Alert! 🚨🚨 We are seeking a full-time Study Coordinator for a NIMH-funded project that aims to uncover cognitive and neural mechanisms underlying maladaptive food-choice behavior in anorexia nervosa using behavior, eye tracking, fMRI, and computational models. Pls spread the word!

Study Coordinator

Department SSD Institute for Mind and Biology: Staff and Temporary Employees About the Department The Eating Disorders Program in the Department of Psychiatry and Behavioral Neuroscience at the Univer...

uchicago.wd5.myworkdayjobs.com

New lab paper! 🧠 Human hippocampal & MTL theta activity is linked to eye movements, but only during memory-guided navigation. Theta is also strongest during longer, more exploratory eye movements. plos.io/4dwJhR8 Huge congrats to Humza & team! 👏

Eye movements reflect memory-related theta activity in the human brain

Theta oscillations in the medial temporal lobe support memory, but how they relate to eye and body movements during human navigation is unclear. This study shows that theta power increases during sacc...

journals.plos.org

PLOS Biology@plosbiology.org · 6mo ago

How do MTL theta oscillations relate to eye & body movements during navigation? @suthanalab.bsky.social &co show that #theta power increases during #saccades under memory demands, linking exploratory gaze & planning to memory‑related dynamics during #navigation @plosbiology.org 🧪 plos.io/4dwJhR8

Experimental design and task. Top left: Intracranial electroencephalographic activity, eye and body movements were recorded as participants freely walked around the room. Wall-mounted motion-tracking cameras recorded the position of on-body reflective markers. Participants also wore an eye-tracking headset to monitor saccadic eye movements. A snapshot from the eye-facing camera is shown in the bottom right. For illustrative purposes, an experimenter is shown wearing the full setup. Top right: MRI of an example participant with an implanted RNS System. Purple dots indicate the location of four electrode contacts in the left medial temporal lobe (MTL). The top left inset shows an X-ray used to localize electrode positions. Bottom left: The environment contained 20 visible wall-mounted signs and three invisible circular target locations (0.7 m diameter). At the start of the task, participants freely explored the room to locate the invisible targets; each time a target was reached, an auditory tone signaled success, allowing them to gradually learn and remember these locations through experience. The task then alternated between two conditions: “visually-cued” navigation, during which participants navigated to a wall-mounted sign (e.g., “Blue 3”), and “memory-cued” navigation, during which they recalled and navigated to the previously learned invisible targets (e.g., “T”).

Long wondered how grid cell activity translates to the hexadirectional fMRI signal. Almog et al. have a neat answer — it's firing *variance* rather than mean rate. Makes sense when you think about it. Worth reading if you work on grid cells or fMRI. https://doi.org/10.64898/2026.03.04.709667

I am excited to share my first paper, showing that episodic memory formation is theta rhythmic, is now published in Nature Human Behavior! Check it out here: rdcu.be/e6pzS. Thanks to my PI, Katherine Duncan, and to my collaborators for their support on this journey! Stay tuned for iEEG follow up 🧠

Episodic memory encoding fluctuates at a theta rhythm of 3–10 Hz

Nature Human Behaviour - Biba et al. show that episodic memory encoding fluctuates at a theta rhythm of 3–10 Hz.

rdcu.be

This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!

Eiko Fried@eikofried.bsky.social · 8mo ago

Would love to hear expert views on this paper. It appears to show that the operationalization of brain activity the field has relied on for 3 decades—the BOLD response—is not actually a sensible measure of brain activity. www.nature.com/articles/s41...