Exclusive: A new analysis refutes James Watson’s claim that he was the first to recognize the significance of the famed photograph 51. https://scim.ag/4rTKck8

How did Rosalind Franklin miss the helix in her iconic DNA image? She didn’t

New analysis refutes James Watson’s claim he was first to recognize significance of famed photograph 51

scim.ag

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Show and Tell: Start Exploring Single-cell Data Julia Ibe walks through a simple four-step workflow for single-cell RNA-seq data showing you how to get the data, prepare it, visualise the cells and ask a biological question. 🧬🧑‍💻 thenode.biologists.com/show-and-tel...

Tracking the growth & fate of 5,000 tagged muscle fibers as a larval #zebrafish develops, using the "palmuscle" method. Credit to Dr. Uday Kumar at Academia Sinica. #ZebrafishZunday 🧪

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection Read this Article from our special issue #DevSIextracellular by @rmraftery.bsky.social, April Craft & co. doi.org/10.1242/dev....

On August 1, 1931, Harriet Creighton and Barbara McClintock published the first experimental proof that genes are physically located on chromosomes—a discovery that transformed genetics. 1/3🧵

Preprint: biorxiv.org/content/10.6... This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n

In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis

The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...

biorxiv.org

Here's what I've been working on in the @allard-lab-ucla.bsky.social, with the help of two excellent undergrads, Keane Bui and Nada Osman, and collaborators Kate Morton, Isabel Kenny-Ganzert, David Sherwood, and Joel Meyer at Duke! www.biorxiv.org/content/10.6...

Dopaminergic neuronal dysfunction induced by newer generation systemic insecticides in Caenorhabditis elegans

While a growing number of studies have linked environmental exposures and Parkinson's disease (PD), the impact of many pesticides remains understudied; for example, neonicotinoids are the most used in...

biorxiv.org

In this Obituary, Francesca Mariani & Mark Lewandoski write about Gail R. Martin, one of developmental biology's most influential conceptual architects, a scientist who reshaped how we think about signalling, pattern formation & genetic analysis in the mouse. doi.org/10.1242/dev....

What if damaged human kidneys could one day repair themselves? At MDI Bio Lab, Iain Drummond, Ph.D., and his team have identified inflammatory signaling pathways in #zebrafish capable of triggering the production of new, functional nephrons without injuring the kidney itself. 🧪 🐟🎸 #NephSky #RenalSky

How to Repair a Kidney Without Making Things Worse

mdibl.org

#zebrafish The M-AB assembly is now up on UCSc in the GenArc hubs (under fishes duh) genome.ucsc.edu/cgi-bin/hgTr... it only has Agustus gene models loaded but you can load up the Ensembl gff if you add it as a custom track. For those who prefer the UCSC browser.

Some great news, Ensembl has released the GRCz12tu and the GRCz12ab annotations on their beta release site, so now the genes can be looked at in a genome browser. You can load up either one (plus a second TU genome) here: beta.ensembl.org/species-sele... #zebrafish

Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 6mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

#DBfeature Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors By Olivia Powell, Emily Garcia, Vanshika Sriram, Yi Qu, Nandan L. Nerurkar tinyurl.com/52pecyc5

(1/15) Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.

Excited to be on my way to ORS! Here is a list of presenters from my lab and when you can see them. Looking forward to seeing everyone soon!

Have you read this? www.lrb.co.uk/the-paper/v4...

Katherine Rundell · Consider the Greenland Shark

I am glad not to be a Greenland shark; I don’t have enough thoughts to fill five hundred years. But I find the very...

lrb.co.uk

Today I would like to share a publication that is particularly meaningful to me. Our tribute to my late mentor, Richard Hynes, has just been published in Matrix Biology. I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor. doi.org/10.1016/j.ma...

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

The molecular basis of force selectivity by PIEZO2

Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

nature.com

Our newest work on quantification and statistical testing of scoliosis severity using microCT and R. www.cell.com/star-protoco... Thanks to @eceatayeter.bsky.social @brittneyvoigt

Protocol for quantifying vertebral column morphology for the statistical analysis of scoliosis severity in zebrafish

Here, we present a protocol for quantifying zebrafish vertebral column morphology using micro-computed tomography (microCT) datasets for scoliosis researchers. We describe steps for orientation of ske...

cell.com

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Ryan Gray@slewzeus.bsky.social · 8mo ago

Our newest work on quantification and statistical testing of scoliosis severity using microCT and R. www.cell.com/star-protoco... Thanks to @eceatayeter.bsky.social @brittneyvoigt

Join @aimbe-official.bsky.social Feb 25, 1–2 PM ET for a webinar on FY2026 appropriations, advocacy strategy, and insights into the medical & biological engineering policy landscape. Learn more and register: https://bit.ly/4cxXcWJ

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells. A great colleague, a friend and a lovely person.

@science.org Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

science.org

Memorializing the contributions of Dr Paul Kulesa to neural crest cell biology & imaging, a generous colleague & mentor, devoted husband and father. @devdynamics.bsky.social @anatomyorg.bsky.social

In Memoriam – Dr. Paul Kulesa (1962‐2025)

Click on the article title to read more.

anatomypubs.onlinelibrary.wiley.com

The NIH has indicated a “leniency” period for implementation of the Common Forms (SciENcv) May 2026: grants.nih.gov/faqs#/common... Note: the “warning” that says your materials are not in compliance is also displayed if you submit using the Common Forms. This warning can be ignored.

I’m recruiting new members to the Farrell Lab this summer. We will have space for 1 postdoc (since Abhinav is leaving to start his own lab at U Arizona!!) and 2 postbacs, since my current two will leave for PhD programs at the end of the summer. More details in thread:

A super interesting historical review in Genetics, chosen completely at random: pmc.ncbi.nlm.nih.gov/articles/PMC...

Lysenkoism Against Genetics: The Meeting of the Lenin All-Union Academy of Agricultural Sciences of August 1948, Its Background, Causes, and Aftermath

This article reviews the ideological, political, economic, social, cultural, personal, moral, and ethical factors that determined the conduct of the Lenin All-Union Academy of Agricultural Sciences session in August 1948, as well as the immediate... ...

pmc.ncbi.nlm.nih.gov

Defending PhD student, looking over their thesis: “If I knew then what I know now, I could’ve done all of this in like 9 months.” A thread about my favorite pioneering cave explorers and why I don’t think AI will ever “solve” biology.

Happy New Year! NEW LAB PREPRINT testing how best4+ intestinal epithelial cells develop! best4+ cells are conserved across vertebrates and altered in IBD & colorectal cancer. But they were first molecularly IDed in 2019. We barely know anything about them yet! What do they do?? HOW DO THEY GET MADE?

Abhinav Sur@abhinavsur.bsky.social · 10mo ago

Closing out 2025 with our new preprint where @jeffreyafarrell.bsky.social and I explore development and function of zebrafish intestinal best4+ cells – molecularly described in 2019, conserved in evolution, absent in 🐭, and altered in inflammatory bowel disease. www.biorxiv.org/content/10.6...