Melissa Franch, PhD
@mfranch.bsky.social
Postdoc in the Hayden lab at Baylor College of Medicine studying neural computations of natural language & communication in humans. Sister to someone with autism. F32 NIDCD Fellow | Autism Research Institute funded | Simons F2F | she/her. melissafranch.com
And on Wednesday afternoon it's time for our Community Event that focuses on what neural encoding models are useful for, where I'll be showcasing several cool projects on EEG encoding during scene perception led by @niklasmuller.bsky.social! 2026.ccneuro.org/community-ev...
Community Event – So You Have a Highly Predictive Model, Now What? Translating Neural Encoding Models into Scientific and Engineering Impact
2026.ccneuro.org
Then on Wednesday, double whammy: in the morning I'll present a poster on our hot-of-the-press EEG decoding study on neural representational dynamics between images vs. video, led by @annewzonneveld.bsky.social (Poster C85) openreview.net/forum?id=njG...
Poster Presentation
2026.ccneuro.org
This project is one of our greatest undertakings as a lab, with Calli at the helm (in terms of data collection, transcription of speech features during naturalistic dialogue, and computational modeling), and we're excited to get everyone's feedback!
I'm over the moon to be recognized for my future plans in (and lifelong commitment to) autism neuroscience research through earning the Simons Foundation Fellows To Faculty award! I can't wait to dive into this work alongside this community✨🥹
We're pleased to announce the 2026 class of our Fellows-to-Faculty program! This fellowship supports talented early-career scientists and their research visions as they transition into tenure-track faculty positions in autism and #neuroscience research. See the new class: https://bit.ly/4yXUjrd
How does your brain register whether something feels good or bad? New research had people listen to stories in an MRI scanner and found the brain maps feelings on a single scale from unpleasant to pleasant, using far more regions than expected. #Valence, #Naturalistic Link: doi.org/10.64898/202...
Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!
Rarely categorical, highly separable representations along the cortical hierarchy - Nature
Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.
nature.com
New paper alert from our lab! nature.com/articles/s41... We used stimuli sequences following 1/f statistical patterns—an ubiquitous statistical structure in natural stimuli—to probe predictive processing in the human brain. How does the brain predict upcoming sensory inputs based on past inputs?
Neural mechanisms of time-forward predictions for naturalistic auditory tone sequences - Nature Communications
A longstanding question is how the brain predicts complex, naturalistic sensory events and updates those predictions when expectations are violated. Using intracranial recordings, the authors show tha...
nature.com
Our new preprint is out!! The human brain runs on ~20 watts. Computers and modern AI systems require vastly higher energy. This gap raises a fundamental question: how does the brain compute so efficiently? In our new study, we take a critical step toward measuring and understanding this directly 1/3
Learning Shapes the Energy Cost of Neural Tasks https://www.biorxiv.org/content/10.64898/2026.07.01.735889v1
Glad to see this story and coverage of an important paper. www.statnews.com/2026/06/17/n... 1/16
NIH diversity programs doubled undergraduates’ odds of getting a Ph.D., 20-year study finds
A new study found that two diversity-oriented programs supported by the NIH doubled the odds that an undergraduate would earn a Ph.D.
statnews.com
1/11 Happy to share our TICS paper on using the flexibility of one of the most basic cognitive functions, perception, to understand one of the most complex cognitive dysfunctions, psychiatric conditions (also my first formal work in computational psychiatry 🎉) 📄: www.cell.com/trends/cogni... 🧵 : 👇
Perceptual multistability: a multifaceted window into brain dysfunctions
Perceptual multistability, observed across species and sensory modalities, offers valuable insights into numerous cognitive functions and dysfunctions. For instance, differences in temporal dynamics a...
cell.com
Online Now: Perceptual multistability: a multifaceted window into brain dysfunctions
Congratulations @xinyuanyan.bsky.social! I’m so grateful to do neuroscience with you. Your blog post provides a clear summary of the research and illustrates your strong skills in communicating your science!
I also wrote a blogpost about our paper, non-technical at all! psywalkeryanxy.github.io/posts/scienc...
New lab paper ! "Shared neural geometries for bilingual semantic representations in human hippocampal neurons" led by @xinyuanyan.bsky.social. 🧵 www.sciencedirect.com/science/arti...
Shared neural geometries for bilingual semantic representations in human hippocampal neurons
The human brain has the remarkable ability to comprehend and express similar concepts in multiple languages. To understand how it does so, we examined…
sciencedirect.com
For many bilingual people, switching between languages feels effortless. Now, scientists have figured out how bilingual brains accomplish this feat at the single neuron level. spkl.io/633297EUXJ Xinyuan Yan, Benjamin, Y. Hayden, @sameershethmd.bsky.social & colleagues @cp-cell.bsky.social
Some neurons like to ride on slow LFP oscillations, regardless of their phase! This might represent a mechanism to coordinate neural activity and propagate information across brain circuits 🧠 amazing collaboration led by the super talented @zahrajourahmad.bsky.social and Andrew Watrous!
Do #neurons show preferential firing at specific oscillatory frequencies? @elebartoli.bsky.social &co use recordings from neurosurgical patients to show that freq of oscillations modulates neuronal firing; implications for freq-targeted #NeuralStimulation @plosbiology.org 🧪 plos.io/44odgVM
Many of the scientific questions we're interested in tackling require studying learning over long periods of time across the brain. This is challenging – which is why we're excited to say we've been developing a system for chronic wireless recording using long Neuropixels probes in macaque monkeys.
Very happy that our manuscript with my brilliant collaborators @jamestrujillo.bsky.social and @straubeb.bsky.social is now published @jneurolang.bsky.social. 🥳🥳🥳 Interested in gesture, discourse, fMRI, prediction, computational modeling? This is the paper for you 👇 doi.org/10.1162/NOL....
Discourse context and co-speech gestures jointly shape hierarchical prediction during the processing of a multimodal narrative
Abstract. Understanding one another in daily communication depends on predicting language from prior discourse context and visual signals, such as co-speech gestures. However, it remains unclear how d...
doi.org
When listening to a story, earlier parts of the story (context) and the speaker's gestures help us predict and understand what they are saying. In a new preprint we show context and gestures have a push-pull synergy on neural response to linguistic information 👇🧵
If you're looking to queer up your timelines with enriching STEM content this #Pride, then @prideinstem.bsky.social has you covered with these three excellent starter packs! go.bsky.app/BFc4wgf go.bsky.app/Cw9bRYZ go.bsky.app/Cw9bRYZ Lift queer voices this month!
Check out our latest profile! Dr. Megan Peters (@meganakpeters.bsky.social) studies how the brain represents & uses uncertainty and she also co-founded the online summer school, Neuromatch Academy. Learn more at the link below! #WomenInNeuroscience #StoriesOfWiN www.storiesofwin.org/profiles/202...
Dr. Megan Peters — Stories of WiN
studies how the brain represents and uses uncertainty and she also co-founded the online summer school, Neuromatch Academy
storiesofwin.org
Info. processing, memory, adaptive decisions.. none of it fully captures what makes us intelligent *beings* with subjective experience. @meganakpeters.bsky.social thinks hard about that gap and how to formalize that in theory & expmt. And she somehow found time to co-build @neuromatch.bsky.social 🤩
Check out our latest profile! Dr. Megan Peters (@meganakpeters.bsky.social) studies how the brain represents & uses uncertainty and she also co-founded the online summer school, Neuromatch Academy. Learn more at the link below! #WomenInNeuroscience #StoriesOfWiN www.storiesofwin.org/profiles/202...
In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N
My new @thetransmitter.bsky.social piece. Does Claude AI have emotions? *No*. Does Claude have nontrivial emotion-equivalents? *Yes*. Like your "memory" vs your laptop's; similar but not the same. Here, I unpack why that's interesting. www.thetransmitter.org/emotion/what...
What can AI teach us about ‘emotions’?
Exploring why Anthropic’s AI, Claude, displays something like emotion could ultimately help us better understand the function that emotions serve in humans.
thetransmitter.org
Another successful New-Bee 🐝 neuro program in the 📚! We were delighted to host Elkins HS for a day of neuroscience demos and lessons. The future is bright with these future STEM leaders! 🤩 Special thanks to generous support from @bcmneurosci.bsky.social and @rsb.org.uk.
Polysemanticity in human hippocampal neurons. When single neurons encode word meanings (concepts), they use the computational principle of superposition.
Because this is a NeuroAI-flavored paper, Xinyuan and I decided to make a blogpost about it: psywalkeryanxy.github.io/posts/scienc...
The anesthetized hippocampus processes language! I've really enjoyed working with new devices for human neuroscience and moving this project forward during my early work at BCM
New paper from the lab! "Plasticity and language in the anaesthetized human hippocampus" www.nature.com/articles/s41...
🥳 Super excited to share our lab's first preprint, led by @hungyun.bsky.social "Distinct tasks engage shared neural subspaces in human hippocampus and anterior cingulate cortex" www.biorxiv.org/content/10.6... 🧵(1/9)
biorxiv.org
502 adolescents (15-17) played an interactive pre-task Cyberball, where they were either excluded or included, and then took part in the Intentions Game (elifesciences.org/articles/104...) to make and predict another's social decisions. We examined both behavioural and computational outcomes...
elifesciences.org
“…the binding problem may be an artifact of theoretical assumptions rather than a real computational challenge for the brain…we propose a framework where the visual cortex represents naturally co-occurring patterns of information rather than processing isolated features that need binding.”
Beyond binding: from modular to natural vision: Trends in Cognitive Sciences www.cell.com/trends/cogni... #neuroskyence #visionscience
Risk reshapes amygdala representation of choice "...these findings reveal how dynamic reshaping of choice-related basolateral amygdala representations underpins behavioral flexibility in the face of risk." www.cell.com/neuron/fullt...
Risk reshapes amygdala representation of choice
Piantadosi et al. show mice flexibly adjust choices between reward options based on the punishment potential in a BLA-dependent manner. They find that BLA neuronal representation of punishment reactiv...
cell.com
Check out our new profile! Dr. Anila D'Mello (@aniladmello.bsky.social) studies language and cognition, and how the underlying brain circuits are altered in neurodevelopmental disorders. Follow the link below to learn more! #WomenInNeuroscience #StoriesOfWiN www.storiesofwin.org/profiles/202...
Dr. Anila D'Mello — Stories of WiN
studies language and cognition, and how the underlying brain circuits are altered in neurodevelopmental disorders
storiesofwin.org