Our new paper on lipids in neural stem cell aging!! Congratulations to Xiaoai Zhao for her fantastic work! ✨🥂 www.science.org/doi/10.1126/...

Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

science.org

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains. bit.ly/4moYLJH

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology

Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

bit.ly

Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social doi.org/10.1038/s435...

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

doi.org

Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!! Congratulations to Paloma Navarro and the entire team! Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab! www.cell.com/immunity/ful...

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

cell.com

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

nature.com

Excited to share our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by Dr. #MinhooKim, published online today at @nataging.nature.com, where we describe surprising findings on the gut/ovary axis. 🧪🖥️🧬. A 🧵1/11 www.nature.com/articles/s43...

Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove

Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week: https://scim.ag/4nFEGO7

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

nature.com

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Hello Bluesky research community. I announce that it's time for lipid cell biology! rdcu.be/d8HKL

Time for lipid cell biology

Nature Cell Biology - It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders...

rdcu.be

The maternal X chromosome impairs cognition and speeds up brain aging. Check out our latest @nature.com @ucsfhealth.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...

The maternal X chromosome affects cognition and brain ageing in female mice - Nature

The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.

nature.com

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

Are you planning to perform single-copy insertions in C. elegans??? Check out our first lab paper!! 🥳 Our *Universal SKI System* uses just one plasmid that can be inserted into any chromosome! Easy peasy! #Celegans #CRISPR #worms #research #science #techniques www.biorxiv.org/content/10.1...

And since we're here... 🥼 Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬 More details via www.imb.de/jobs Application deadline is 5 January 2025 #sciencejobs #resilience #biostatistics

My lab is looking for a computational postdoc with expertise in AI/ML using genomics single cell datasets. If you are excited about diving into the mysteries of aging and longevity research using large genomics datasets, please apply! www.linkedin.com/jobs/view/38...