Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance - Nature Communications

Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...

nature.com

So excited my PhD work is finally out! A huge collaborative effort of the Ruprecht lab, especially of my co-authors @laurafbianchi.bsky.social & @hannamariahakkinen.bsky.social Check below Laura's thread if you want to know more about E-cadherin novel and unexpected role in epithelial phagocytosis

Laura Bianchi@laurafbianchi.bsky.social · 2w ago

Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...

I'm extremely happy to say that a new preprint from Ruprecht lab is out! Check it to to know more about a novel role for the E-cadherin/catenin complex in controlling epithelial phagocytosis 🍽🐟🔬

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 9mo ago

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1

Features new works from Stankunas Lab @uoregon.bsky.social, Ruprecht Lab @crg.eu & @campaslab.bsky.social (albeit mammals this time 😉)

FocalPlane @focalplane.bsky.social · 9mo ago

ICYMI, our #preprint list is now up on FocalPlane, highlighting the latest research using #microscopy to answer questions in #biology. As always, send us any recommendations for preprints that we've missed: focalplane.biologists.com/2025/12/12/m...

How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work! www.nature.com/articles/s41... www.nature.com/articles/s41...

Target cell cortical tension regulates macrophage trogocytosis - Nature Cell Biology

Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...

nature.com

📝 New preprint from the lab lead by Hanna Häkkinen, @martabatetpalau.bsky.social, and @laurafbianchi.bsky.social! The mechanics on how the early embryo stays clear from apoptotic debris. A surprising role for E-cadherin in non-professional phagocytic clearance 🍝.

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 9mo ago

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1

🔥 Piping hot; fresh from the oven! Fever-like conditions accelerate immune cell speed and efficiency through thermoregulation of actomyosin contractility. Congrats to Ivan Company-Garrido, @alempheius.bsky.social, and @mcolomerr.bsky.social on this huge collaborative effort.

Mariona Colomer Rosell@mcolomerr.bsky.social · 10mo ago

Ever wonder what happens to immune cells when we get a fever? Exicted to share our paper showing that temperature regulates immune cell migration via myosinII! A wonderful collaboration with Ivan, @alempheius.bsky.social, @valeriaventurini.bsky.social & all co-authors! bit.ly/48XRVGj

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

Super cool new research from the lab in collab with our lab neighbors :)

Sdelci Lab@sdelcilab.bsky.social · last yr.

🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu Mechanobiology meets Nuclear Metabolism www.nature.com/articles/s41...

🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇

Thrilled to share that our "Poster at a Glance" on #Phagocytosis is out! Thank you @jcellsci.bsky.social @biologists.bsky.social for the invitation ! Prepared with @manondepierre.bsky.social @chiarapompili.bsky.social from @institutcochin.bsky.social journals.biologists.com/jcs/article/...

Phagocytosis at a glance

Summary: Phagocytosis involves receptor-driven actin and membrane remodelling to engulf microbes and debris. The phagosome then matures for degradation, supporting both nutrition and immune responses.

journals.biologists.com

Now online! Tissue geometry spatiotemporally drives bacterial infections

Tissue geometry spatiotemporally drives bacterial infections

Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.

dlvr.it

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story: www.cell.com/cell-host-mi...

Do you want to join us to work in neurodevelopmental biology? Please apply 👇 #SEBD

I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper! www.cell.com/iscience/ful...

A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment

Cell biology; Organizational aspects of cell biology; Specialized functions of cells; Functional aspects of cell biology

cell.com

The job call is officially open. If you're interested, please apply through this link ASAP! 😃 www.mdc-berlin.de/career/jobs/... Please RT! 🙏

Manuel Irimia@mirimiam.bsky.social · 2y ago

🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and travelling Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com Please RT! 🙏