Javi Martínez-López
@javiml221098.bsky.social
Biochemist and Immunology MsC🧪 PhD Student in FIBAO 🖥️🧬 Instituto de Parasitología y Biomedicina López-Neyra (CSIC) 📍 https://orcid.org/0000-0003-0184-9543
Hoy, en el Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), Carlos de la Rosa Báez ha dado su seminario WIP en inglés. El título ha sido ‘Novel HLA Class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease’.
📢 ¿Sabías que la esclerodermia no afecta igual a hombres y mujeres? Nuestro último estudio publicado en @thelancetrheum.bsky.social analiza estas diferencias clave para entender mejor la enfermedad Si queréis saber más, podéis leer la nota de prensa @csic.es @ipblncsic.bsky.social👇📖
CSIC@csic.es · 5mo ago🏥La #esclerodermia es una #EnfermedadRara que ataca los tejidos 👩🦰Afecta más a mujeres, aunque es más grave en hombres 🔬Un estudio del @ipblncsic.bsky.social arroja luz sobre estas diferencias 🔎Revela marcadores genéticos específicos para cada sexo ➡️ https://f.mtr.cool/qyinfqsttn
🏥La #esclerodermia es una #EnfermedadRara que ataca los tejidos 👩🦰Afecta más a mujeres, aunque es más grave en hombres 🔬Un estudio del @ipblncsic.bsky.social arroja luz sobre estas diferencias 🔎Revela marcadores genéticos específicos para cada sexo ➡️ https://f.mtr.cool/qyinfqsttn
NEW RESEARCH—Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study bit.ly/3OHY4ys Plus, linked Comment bit.ly/4e8AvJK #Medsky #Rheumsky
Ya está disponible en YouTube la entrevista de la Dr. Ana Márquez Ortiz investigadora principal del IPBLN. 🔸Línea de Investigación: Bases moleculares de la arteritis de células gigantes. 👉 Enlace a la entrevista: youtu.be/uwCsVBEJKvE
Entrevista (Interview) | Ana Márquez Ortiz
YouTube video by Inst. de Parasitología y Biomedicina López-Neyra
youtu.be
At today’s WIP Seminar, Gonzalo Borrego-Yaniz ( @goboru.bsky.social ), a PhD candidate from Dr. Ana Márquez’s lab, presented their latest research on giant cell arteritis, a rare inflammatory disease that mainly affects older adults.
This week’s WIP Seminar at the IPBLN was presented by Javi Martínez-López (@javiml221098.bsky.social), a PhD candidate and researcher at IPBLN-CSIC. He shared part of his work on identifying causal genetic variants associated with Systemic Sclerosis, a rare autoimmune disease, using (+)
📅ACTIVIDADES SEMANA → 26-30/01/2026. MARTES 27 WIP de Javier Martínez: ‘Massively Parallel Reporter Assays (MPRA): a systematic approach in functional genomics'. VIERNES 30. Seminario Dr. Juan Ignacio Peruchena: '¿Cómo protegemos los resultados de investigación en el CSIC (Andalucía)?
Identifican nuevas claves moleculares que podrían guiar el manejo clínico de la enfermedad de Erdheim–Chester El @ipblncsic.bsky.social marca un punto de inflexión con su estudio de esta enfermedad, analizando y combinando por primera vez datos de metilación del ADN y expresión génica t.ly/MCs11
For the next three months I am doing a stay at the University of Manchester! Prof. Gisela Orozco's lab, in a project working on ATAC-seq and CUT&Tag data. Happy to be here!! 🌸 (also my first time in the UK! 😊) @manchester.ac.uk
New paper just out (online first) in Arthritis & Rheumatology! 🎉 We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵 Read: doi.org/10.1002/art.... cc @ipblncsic.bsky.social
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...
doi.org
To be part of the 19th SSc Workshop in Cambridge was an amazing experience! It was a privilege to have had the opportunity to give a talk about massively parallel reporter assays (MPRAs). And with that… it’s summer time! 🌞✨
IPBLN-CSIC @ipblncsic.bsky.social · last yr.¡DESPEDIMOS el curso con una gran felicitación a nuestros compañeros @javiml221098.bsky.social, Marialbert Acosta-Herrera, Carlos de la Rosa Báez e @inmaculadaroma.bsky.social del IPBLN por su notable presencia en el 19th International Workshop on Scleroderma Research! 👏🎊🥳🎉
These past days I had the amazing opportunity to attend the International Workshop on Scleroderma Research in Cambridge. Thanks to the SCTC for awarding me with a Workshop Travel Award 🙌🏻
If you want some immune cells for your slides, here’s what you’re looking for🙌🏻
Gonzalo Borrego-Yaniz@goboru.bsky.social · last yr.🎨🔬 I just released some simple immune cell illustrations I've made over time for my talks, for anyone to use in their talks, teaching, or outreach! No attribution required, just not for commercial use. You can download them from my github 👉 github.com/goboru/cell-... #SciComm #Immunesky #sciart
SOOOO MANY GENOMICS MODELSSSS! 😱 Often unclear which is best since they benchmark differently! In this preprint, we introduce GAME, a new framework that utilizes APIs to enable sustainable, uniform model evaluation so we can see which is actually best for each task. doi.org/10.1101/2025...
Methods and applications for single-cell and spatial multi-omics go.nature.com/3GkzmzZ #Review by Katy Vandereyken, Alejandro Sifrim, @bernthie.bsky.social & Thierry Voet Free to read here: rdcu.be/c6JjL
Methods and applications for single-cell and spatial multi-omics
Nature Reviews Genetics - In this Review, the authors discuss the latest advances in profiling multiple molecular modalities from single cells, including genomic, transcriptomic, epigenomic and...
rdcu.be
EULAR2025 has come to an end! I learned a lot, met amazing people, and had a great time with @goboru.bsky.social and @lauramg22.bsky.social. Really enjoyed it! ✨✨
Last day of EULAR! Here's a thread 🧵 of my (very personal) takeaways from #EULAR2025 on giant cell arteritis (GCA)! Keep in mind that as someone focused on basic research, my EULAR schedule was definitely biased in that direction #GCA #rheumsky
Great presentation by my lab mate @inmaculadaroma.bsky.social ✨ Sex-aware science is something to stand strong for ✊
IPBLN-CSIC @ipblncsic.bsky.social · last yr.🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX. Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
We show that the X chromosome, understudied in genome-wide association studies, contributes to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full X inactivation bal...
cell.com
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰 Huge thanks to the committee, I’m truly honored! Hope to see you in Barcelona! #EMEUNET #EULAR2025
Today marks #WorldImmunologyDay 2025: The immune system and your brain. Multiple system atrophy is a rare synucleinopathy that affects the nigrostriatal system, pons, cerebellum, inferior olives, brainstem and spinal cord. Learn more: https://www.nature.c...
Happy to see our paper on "The Spanish Polygenic Score reference distribution: a resource for personalized medicine" out nature.com/articles/s41... this is a collaborative effort of the CIBERER, Navarrabiomed and other groups across Spain @ibis-investigacion.bsky.social
The Spanish Polygenic Score reference distribution: a resource for personalized medicine - European Journal of Human Genetics
European Journal of Human Genetics - The Spanish Polygenic Score reference distribution: a resource for personalized medicine
nature.com
¿Conoces #HuMicA! 🌟 Investiga el papel de la microglía en enfermedades neurodegenerativas y su potencial terapéutico. Te lo cuentan sus autores en #RevistaSEBBM https://f.mtr.cool/stowmipiea
In This Issue: •Epigenetic myeloid dysregulation in SSc •Incidence of JIA increases with latitude in Norway cohort •FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE •Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx acr.tw/4hLtPzi #Medsky
