Tomoaki Sobajima
@tomogolgier.bsky.social
Postdoc in Barr Lab, Department of Biochemistry, University of Oxford | Trinity College #cellcycle #mitosis #membranetraffic https://scholar.google.co.uk/citations?hl=en&user=yUcbgLoAAAAJ&view_op=list_works&sortby=pubdate https://twitter.com/tomogolgier
PhD studentships @mrc-lms.bsky.social open now!
MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · 4d agoWe are launching 12 new #PhD opportunities today! We have studentships spanning protein design, sex differences in immunity, GLP-1 medicines and metabolism, spatial genomics and 4D cancer imaging. 📆 Deadline: Thursday 18th November (9:00) ✍️ Apply here: lms.mrc.ac.uk/work-and-stu...
🥉 🎉
Ro de Jong 🧒@rodejong.bsky.social · 3mo ago#England and #France put on a 4️⃣ 🆚 6️⃣ show in the penultimate game of the 2026 World Cup 👏 0-1 ⚽03' | Rice 0-2 ⚽ 19' | Konsa 0-3 ⚽ 37' | Saka 0-4 ⚽ 45'+1 | Saka 1-4 ⚽48' | MBappé 2-4 ⚽54' | Barcola 3-4 ⚽66' | MBappé 3-5 ⚽86' | Saka 4-5 ⚽90'+5 | Dembélé 4-6 ⚽90'+8 | Bellingham #FRAENG #Worldcup
We're looking for a new Roving Research @mrc-lms.bsky.social A unique post for those who love research, learning new techniques & working across different teams. Must be a great communicator & well organised! Apply by 21 June: fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
Investigator Scientist Roving Researcher
Investigator Scientist (Roving Researcher) (LMS 2369) Salary £42,159 – 44,801 plus London Allowance (£5,560) per annum | 2 years fixed term | Full time | Closing Date: 21 June
fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com
Genome instability triggers intercellular DNA transfer between human cells: Cell www.cell.com/cell/fulltex...
Genome instability triggers intercellular DNA transfer between human cells
Mammalian cells can pass damaged pieces of their genome directly to neighboring cells via contact-dependent, nanotube-like connections. These transferred DNA fragments persist and function, revealing ...
cell.com
Microtubule dynamics control the direction of cardiomyocyte growth | Science www.science.org/doi/10.1126/...
Microtubule dynamics control the direction of cardiomyocyte growth
The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...
science.org
RNA-triggered cell killing with CRISPR–Cas12a2 www.nature.com/articles/s41...
RNA-triggered cell killing with CRISPR–Cas12a2 - Nature
Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infe...
nature.com
www.nature.com/articles/s41...
Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling - Nature Communications
The role of lumen acidification during endosome maturation has been unclear. Here, the authors show that proton efflux via a Na+/H+ exchanger is detected by a pH-sensitive Rab GAP, which promotes endo...
nature.com
Toward life with a 19–amino acid alphabet through generative artificial intelligence design | Science www.science.org/doi/10.1126/...
Toward life with a 19–amino acid alphabet through generative artificial intelligence design
Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...
science.org
www.nature.com/articles/s41...
Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability - Nature Cell Biology
Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...
nature.com
Mechanical load inhibits cancer growth in mouse and human hearts | Science www.science.org/doi/10.1126/...
Mechanical load inhibits cancer growth in mouse and human hearts
The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...
science.org
Nuclear envelope budding enables export of large transcripts in muscle cells: Cell www.cell.com/cell/fulltex...
Nuclear envelope budding enables export of large transcripts in muscle cells
During myogenesis, inner nuclear membrane buds export extremely long sarcomeric transcripts. UIF controls RNA cargo targeting into these buds, and ESCRT-III remodeling is required to internalize UIF a...
cell.com
What I learned today: Actin branch angle: around 70 degrees 😲 PNAS 1998 www.pnas.org/doi/full/10.... Actin branching, primarily mediated by the Arp2/3 complex, typically occurs at a characteristic angle of 70° ± 7° between the mother filament and the new daughter filament.
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
www.nature.com/articles/s41...
A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin - Nature
CRISPR screening shows that claudin-4 is a receptor for the pro-carcinogenic B. fragilis toxin on colonic epithelial cells, and that this interaction promotes cleavage of E-cadherin, le...
nature.com
The cryptic lncRNA-encoded microprotein TPM3P9 promotes #ccRCC tumorigenesis by driving #Oncogenic RNA splicing, revealing a novel regulatory mechanism and potential #TherapeuticTarget in #RenalCancer. #STTT #OpenAccess: doi.org/10.1038/s413...
www.nature.com/articles/s41...
Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology
Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...
nature.com
The dynamics of centromere assembly and disassembly during quiescence url: rupress.org/jcb/article/...
The dynamics of centromere assembly and disassembly during quiescence
Marescal et al. show that quiescent cells disassemble their centromeres through the transcriptional downregulation of most centromere proteins while preser
rupress.org
www.nature.com/articles/s41...
A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development - Nature Communications
A single base pair insertion in the Sox9 enhancer, Enh13, mediates XX female-to-male sex reversal. This subtle non-coding mutation reconfigures transcriptional regulation, enhances Sox9 expression, re...
nature.com
This researcher created a fictional illness, and fake studies funded by the Professor Sideshow Bob Foundation and University of the Fellowship of the Ring and the Galactic Triad. LLMs warned people the illness was real. go.nature.com/48mAyh9
Scientists invented a fake disease. AI told people it was real
Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?
go.nature.com
Great conference, great science and great location!
Ross Chapman@rosschapmanlab.bsky.social · 6mo agoExcited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!
Online now! Online now! Control of the signaling of RAS proteins by modulating their palmitoylation #chembiol
Control of the signaling of RAS proteins by modulating their palmitoylation
Zhu et al. report an approach to reversibly control protein S-palmitoylation by fusing the depalmitoylase APT1 to target proteins. Using RAS proteins, they show that this approach enables the dynamic modulation of RAS palmitoylation and membrane localization by an APT1 inhibitor, and offers a platform for screening RAS palmitoyltransferase inhibitors.
dlvr.it
“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...
Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice. Learn more in a new #SciencePerspective: https://scim.ag/3N9Utsu
KRAShing pancreatic cancer before takeoff
Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice
scim.ag
De novo design of Ras isoform selective binders
De novo design of Ras isoform selective binders
Zhang et al. use deep learning-based protein design to create isoform-specific Ras binders that selectively target the disordered C termini. These tools enable precise dissection of Ras isoform functions and uncover distinct Ras dependencies that emerge during RasG12C inhibitor resistance.
dlvr.it
Loss of the ubiquitin ligase targeting factor KEAP1 induces NRF2-driven reductive stress, revealing KEAP1-dependent therapeutic vulnerabilities of KEAP1-mutant NSCLC, particularly under metabolic stress @idikic.bsky.social @diefenbacherlab.bsky.social and coworkers link.springer.com/article/10.1...
Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer - The EMBO Journal
Lung cancer cells rely on protein homeostasis regulators, particularly the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases...
link.springer.com
link.springer.com/article/10.1...
Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal
Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...
link.springer.com
Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work! @oxfordbiochemistry.bsky.social www.nature.com/articles/s41...
Structural basis for prostaglandin and drug transport via SLCO2A1
Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...
nature.com
